Constitutional epimutations in LTBP4, a component of the TGF-β signaling, and in BRCA1, as potential drivers of early-onset colorectal cancer
LTBP4（TGF-β信号通路的一个组成部分）和BRCA1的体细胞表观突变可能是早发性结直肠癌的潜在驱动因素。
期刊:Clinical Epigenetics
影响因子:4.4
doi:10.1186/s13148-025-01924-x
Terradas, Mariona; Mur, Pilar; Morón-Duran, Francisco D; Mengod, Pol; Löffler, Chiara M L; Helderman, Noah C; Terlouw, Diantha; Sanjuán, Xavier; Bousquets-Muñoz, Pablo; Viana-Errasti, Julen; Puente, Xose S; Capellá, Gabriel; Nielsen, Maartje; van Wezel, Tom; Kather, Jakob Nikolas; Lázaro, Conxi; Moreno, Victor; Valle, Laura
肿瘤
肠癌
表观遗传
肿瘤免疫
TGF-β
信号转导
BRCA1
TBP
细胞生物学
