日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Allosteric Modulation of Pathological Ataxin-3 Aggregation: A Path to Spinocerebellar Ataxia Type-3 Therapies

病理性共济蛋白-3聚集的变构调节:脊髓小脑性共济失调3型治疗的途径

Silva, Alexandra; Duarte-Silva, Sara; Martins, Pedro M; Rodrigues, Beatriz; Serrenho, Débora; Vilasboas-Campos, Daniela; Teixeira-Castro, Andreia; Vieyto-Nuñez, Julio; Mieres-Perez, Joel; Figueiredo, Francisco; Podlasiak, Martyna; Van-der-Kellen, Tatiana; Fraga, Joana; Noble, James; Lantz, Carter; Sepanj, Niki; Monteiro-Fernandes, Daniela; Guerreiro, Sara; Neves-Carvalho, Andreia; Pereira-Sousa, Joana; Klärner, Frank-Gerrit; Schrader, Thomas; Loo, Joseph A; Pastore, Annalisa; Sanchez-Garcia, Elsa; Bitan, Gal; Carvalho, Ana Luísa; Maciel, Patrícia; Macedo-Ribeiro, Sandra

Anti-amyloid treatment is broadly effective in neuronopathic mucopolysaccharidoses and synergizes with gene therapy in MPS-IIIA

抗淀粉样蛋白治疗对神经病性粘多糖病具有广泛疗效,并与 MPS-IIIA 的基因治疗产生协同作用

Marianna Giaccio, Antonio Monaco, Laura Galiano, Andrea Parente, Luigi Borzacchiello, Riccardo Rubino, Frank-Gerrit Klärner, Dennis Killa, Claudia Perna, Pasquale Piccolo, Marcello Marotta, Xuefang Pan, Marie Khijniak, Ibrar Siddique, Thomas Schrader, Alexey V Pshezhetsky, Nicolina Cristina Sorrenti

Molecular Tweezers: Supramolecular Hosts with Broad-Spectrum Biological Applications

分子镊子:具有广泛生物学应用的超分子宿主

Shahpasand-Kroner, Hedieh; Siddique, Ibrar; Malik, Ravinder; Linares, Gabriel R; Ivanova, Magdalena I; Ichida, Justin; Weil, Tatjana; Münch, Jan; Sanchez-Garcia, Elsa; Klärner, Frank-Gerrit; Schrader, Thomas; Bitan, Gal

Characterization of Molecular Tweezer Binding on α-Synuclein with Native Top-Down Mass Spectrometry and Ion Mobility-Mass Spectrometry Reveals a Mechanism for Aggregation Inhibition

利用天然自上而下质谱和离子迁移质谱对分子镊子与α-突触核蛋白的结合进行表征,揭示了其抑制聚集的机制

Lantz, Carter; Lopez, Jaybree; Goring, Andrew K; Zenaidee, Muhammad A; Biggs, Karl; Whitelegge, Julian P; Ogorzalek Loo, Rachel R; Klärner, Frank-Gerrit; Schrader, Thomas; Bitan, Gal; Loo, Joseph A

The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease

淀粉样蛋白抑制剂CLR01可缓解自噬并改善严重溶酶体贮积症的神经病理学症状

Monaco, Antonio; Maffia, Veronica; Sorrentino, Nicolina Cristina; Sambri, Irene; Ezhova, Yulia; Giuliano, Teresa; Cacace, Vincenzo; Nusco, Edoardo; De Risi, Maria; De Leonibus, Elvira; Schrader, Thomas; Klärner, Frank-Gerrit; Bitan, Gal; Fraldi, Alessandro

Advanced Molecular Tweezers with Lipid Anchors against SARS-CoV-2 and Other Respiratory Viruses

具有脂质锚的先进分子镊子可对抗 SARS-CoV-2 和其他呼吸道病毒

Tatjana Weil, Abbna Kirupakaran, My-Hue Le, Philipp Rebmann, Joel Mieres-Perez, Leila Issmail, Carina Conzelmann, Janis A Müller, Lena Rauch, Andrea Gilg, Lukas Wettstein, Rüdiger Groß, Clarissa Read, Tim Bergner, Sandra Axberg Pålsson, Nadja Uhlig, Valentina Eberlein, Heike Wöll, Frank-Gerrit Klärn

Acceleration of Magnetic Resonance Fingerprinting Reconstruction Using Denoising and Self-Attention Pyramidal Convolutional Neural Network

利用去噪和自注意力金字塔卷积神经网络加速磁共振指纹重建

Hong, Jia-Sheng; Hermann, Ingo; Zöllner, Frank Gerrit; Schad, Lothar R; Wang, Shuu-Jiun; Lee, Wei-Kai; Chen, Yung-Lin; Chang, Yu; Wu, Yu-Te

The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice

分子钳 CLR01 可改善 P301S-tau 转基因小鼠的行为缺陷并减少 tau 病理

Jing Di #, Ibrar Siddique #, Zizheng Li, Ghattas Malki, Simon Hornung, Suman Dutta, Ian Hurst, Ella Ishaaya, Austin Wang, Sally Tu, Ani Boghos, Ida Ericsson, Frank-Gerrit Klärner, Thomas Schrader, Gal Bitan

Correction to: The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice

更正:分子镊子CLR01改善P301S-tau转基因小鼠的行为缺陷并减少tau蛋白病理

Di, Jing; Siddique, Ibrar; Li, Zizheng; Malki, Ghattas; Hornung, Simon; Dutta, Suman; Hurst, Ian; Ishaaya, Ella; Wang, Austin; Tu, Sally; Boghos, Ani; Ericsson, Ida; Klärner, Frank-Gerrit; Schrader, Thomas; Bitan, Gal

Inhibition of Staphylococcus aureus biofilm-forming functional amyloid by molecular tweezers.

利用分子镊子抑制金黄色葡萄球菌生物膜形成功能性淀粉样蛋白

Malishev Ravit, Salinas Nir, Gibson James, Eden Angela Bailey, Mieres-Perez Joel, Ruiz-Blanco Yasser B, Malka Orit, Kolusheva Sofiya, Klärner Frank-Gerrit, Schrader Thomas, Sanchez-Garcia Elsa, Wang Chunyu, Landau Meytal, Bitan Gal, Jelinek Raz