日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Process development for production of non-originator NISTmAb from CHO and NS0 cell lines.

利用 CHO 和 NS0 细胞系生产非原研 NISTmAb 的工艺开发

Fratz-Berilla Erica J, Azer Nicole, Bush Xin, Kim JungHyun, Kohnhorst Casey

Temporal Galactose-Manganese Feeding in Fed-Batch and Perfusion Bioreactors Modulates UDP-Galactose Pools for Enhanced mAb Glycosylation Homogeneity

在补料分批和灌流生物反应器中,定时添加半乳糖-锰可以调节UDP-半乳糖池,从而提高mAb糖基化的均一性。

Gyorgypal, Aron; Fratz-Berilla, Erica; Kohnhorst, Casey; Powers, David N; Chundawat, Shishir P S

Evaluation of single-use optical and electrochemical pH sensors in upstream bioprocessing

一次性光学和电化学 pH 传感器在上游生物加工中的评估

Erica J Fratz-Berilla, Casey Kohnhorst, Nicholas Trunfio, Xin Bush, Aron Gyorgypal, Cyrus Agarabi

Glycolytic flux control by drugging phosphoglycolate phosphatase

通过药物控制磷酸乙醇酸磷酸酶来控制糖酵解通量

Elisabeth Jeanclos #, Jan Schlötzer #, Kerstin Hadamek, Natalia Yuan-Chen, Mohammad Alwahsh, Robert Hollmann, Stefanie Fratz, Dilan Yesilyurt-Gerhards, Tina Frankenbach, Daria Engelmann, Angelika Keller, Alexandra Kaestner, Werner Schmitz, Martin Neuenschwander, Roland Hergenröder, Christoph Sotriff

Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension

miR-130/301通过系统水平调控microRNA网络促进肺动脉高压的发生。

Bertero, Thomas; Lu, Yu; Annis, Sofia; Hale, Andrew; Bhat, Balkrishen; Saggar, Rajan; Saggar, Rajeev; Wallace, W Dean; Ross, David J; Vargas, Sara O; Graham, Brian B; Kumar, Rahul; Black, Stephen M; Fratz, Sohrab; Fineman, Jeffrey R; West, James D; Haley, Kathleen J; Waxman, Aaron B; Chau, B Nelson; Cottrill, Katherine A; Chan, Stephen Y

Impacts on product quality attributes of monoclonal antibodies produced in CHO cell bioreactor cultures during intentional mycoplasma contamination events

故意发生支原体污染事件对 CHO 细胞生物反应器培养中产生的单克隆抗体产品质量属性的影响

Erica J Fratz-Berilla, Phillip Angart, Ryan J Graham, David N Powers, Adil Mohammad, Casey Kohnhorst, Talia Faison, Sai Rashmika Velugula-Yellela, Nicholas Trunfio, Cyrus Agarabi

Real-time quantification and supplementation of bioreactor amino acids to prolong culture time and maintain antibody product quality

实时定量和补充生物反应器氨基酸,以延长培养时间并保持抗体产品质量

David N Powers, Yifan Wang, Erica J Fratz-Berilla, Sai Rashmika Velugula-Yellela, Brittany Chavez, Phillip Angart, Nicholas Trunfio, Seongkyu Yoon, Cyrus Agarabi

Asymmetric Dimethylarginine Stimulates Akt1 Phosphorylation via Heat Shock Protein 70-Facilitated Carboxyl-Terminal Modulator Protein Degradation in Pulmonary Arterial Endothelial Cells

不对称二甲基精氨酸通过热休克蛋白70促进的羧基末端调节蛋白降解来刺激肺动脉内皮细胞中Akt1的磷酸化

Sun, Xutong; Kellner, Manuela; Desai, Ankit A; Wang, Ting; Lu, Qing; Kangath, Archana; Qu, Ning; Klinger, Christina; Fratz, Sohrab; Yuan, Jason X-J; Jacobson, Jeffrey R; Garcia, Joe G N; Rafikov, Ruslan; Fineman, Jeffrey R; Black, Stephen M

Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit

基质重塑通过反馈机械激活 YAP/TAZ-miR-130/301 回路促进肺动脉高压

Thomas Bertero, Katherine A Cottrill, Yu Lu, Christina M Haeger, Paul Dieffenbach, Sofia Annis, Andrew Hale, Balkrishen Bhat, Vivek Kaimal, Ying-Yi Zhang, Brian B Graham, Rahul Kumar, Rajan Saggar, Rajeev Saggar, W Dean Wallace, David J Ross, Stephen M Black, Sohrab Fratz, Jeffrey R Fineman, Sara O

Human Erythroid 5-Aminolevulinate Synthase Mutations Associated with X-Linked Protoporphyria Disrupt the Conformational Equilibrium and Enhance Product Release

与 X 连锁原卟啉症相关的人类红细胞 5-氨基乙酰丙酸合酶突变会破坏构象平衡并增强产品释放

Erica J Fratz, Jerome Clayton, Gregory A Hunter, Sarah Ducamp, Leonid Breydo, Vladimir N Uversky, Jean-Charles Deybach, Laurent Gouya, Hervé Puy, Gloria C Ferreira