日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Monitoring ctDNA RAS Mutational Status in Metastatic Colorectal Cancer: A Trial Protocol of RAS-trace and RAS-trace-2 Studies

监测转移性结直肠癌中ctDNA RAS突变状态:RAS-trace和RAS-trace-2研究的试验方案

Kataoka, Kozo; Yamada, Takeshi; Shiozawa, Manabu; Takase, Naoto; Ito, Kazuma; Yamazaki, Kentaro; Watanabe, Jun; Kudo, Toshihiro; Suto, Takeshi; Matsumoto, Toshihiko; Murata, Kohei; Suwa, Yusuke; Boku, Shogen; Yasui, Hisateru; Matsuhashi, Nobuhisa; Maeda, Atsuyuki; Sugimoto, Kiichi; Matsumoto, Yusuke; Yokota, Mitsuru; Fredebohm, Johannes; Mori, Keita; Ikeda, Masataka

Broad spectrum of regorafenib activity on mutant KIT and absence of clonal selection in gastrointestinal stromal tumor (GIST): correlative analysis from the GRID trial

瑞戈非尼对突变型KIT具有广谱活性,且在胃肠道间质瘤(GIST)中未观察到克隆选择:GRID试验的相关性分析

Jeffers, Michael; Kappeler, Christian; Kuss, Iris; Beckmann, Georg; Mehnert, Daniel H; Fredebohm, Johannes; Teufel, Michael

Clearance of ctDNA in triple-negative and HER2-positive breast cancer patients during neoadjuvant treatment is correlated with pathologic complete response

在接受新辅助治疗的三阴性乳腺癌和HER2阳性乳腺癌患者中,ctDNA的清除与病理完全缓解相关。

Ciriaco, Nikaoly; Zamora, Esther; Escrivá-de-Romaní, Santiago; Miranda Gómez, Ignacio; Jiménez Flores, José; Saura, Cristina; Sloane, Hillary; Starus, Anna; Fredebohm, Johannes; Georgieva, Lucy; Speight, Graham; Jones, Frederick; Ramón Y Cajal, Santiago; Espinosa-Bravo, Martín; Peg, Vicente

Prospective study evaluating dynamic changes of cell-free HPV DNA in locoregional viral-associated oropharyngeal cancer treated with induction chemotherapy and response-adaptive treatment

前瞻性研究评估接受诱导化疗和反应适应性治疗的局部区域病毒相关口咽癌患者体内游离HPV DNA的动态变化

Rosenberg, Ari J; Izumchenko, Evgeny; Pearson, Alexander; Gooi, Zhen; Blair, Elizabeth; Karrison, Theodore; Juloori, Aditya; Ginat, Daniel; Cipriani, Nicole; Lingen, Mark; Sloane, Hillary; Edelstein, Daniel L; Keyser, Kirsten; Fredebohm, Johannes; Holtrup, Frank; Jones, Frederick S; Haraf, Daniel; Agrawal, Nishant; Vokes, Everett E

Detection of TP53 and PIK3CA Mutations in Circulating Tumor DNA Using Next-Generation Sequencing in the Screening Process for Early Breast Cancer Diagnosis

利用新一代测序技术检测循环肿瘤DNA中的TP53和PIK3CA突变,以进行早期乳腺癌诊断筛查

Rodriguez, Begona Jimenez; Córdoba, Gema Diaz; Aranda, Alicia Garrido; Álvarez, Martina; Vicioso, Luis; Pérez, Casilda Llácer; Hernando, Cristina; Bermejo, Begoña; Parreño, Ana Julve; Lluch, Ana; Ryder, Matthew B; Jones, Frederick S; Fredebohm, Johannes; Holtrup, Frank; Queipo-Ortuño, María Isabel; Alba, Emilio

The deubiquitinating enzyme USP5 promotes pancreatic cancer via modulating cell cycle regulators

去泛素化酶USP5通过调节细胞周期调节因子促进胰腺癌的发生发展

Kaistha, Brajesh P; Krattenmacher, Anja; Fredebohm, Johannes; Schmidt, Harald; Behrens, Diana; Widder, Miriam; Hackert, Thilo; Strobel, Oliver; Hoheisel, Jörg D; Gress, Thomas M; Buchholz, Malte

Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs

甲基异靛蓝通过抑制 LKB1 和激活 PDAC 中的 AMPK 来干扰细胞代谢,从而优先杀死癌症干细胞

Xinlai Cheng, Jee Young Kim, Shahrouz Ghafoory, Tijen Duvaci, Roya Rafiee, Jannick Theobald, Hamed Alborzinia, Pavlo Holenya, Johannes Fredebohm, Karl-Heinz Merz, Arianeb Mehrabi, Mohammadreza Hafezi, Arash Saffari, Gerhard Eisenbrand, Jörg D Hoheisel, Stefan Wölfl

Performance of Streck cfDNA Blood Collection Tubes for Liquid Biopsy Testing

Streck cfDNA血液采集管在液体活检检测中的性能

Medina Diaz, Inga; Nocon, Annette; Mehnert, Daniel H; Fredebohm, Johannes; Diehl, Frank; Holtrup, Frank

High throughput synthetic lethality screen reveals a tumorigenic role of adenylate cyclase in fumarate hydratase-deficient cancer cells

高通量合成致死筛选揭示腺苷酸环化酶在富马酸水合酶缺乏的癌细胞中的致瘤作用

Michael Boettcher, Andrew Lawson, Viola Ladenburger, Johannes Fredebohm, Jonas Wolf, Jörg D Hoheisel, Christian Frezza, Tomer Shlomi

A mammosphere formation RNAi screen reveals that ATG4A promotes a breast cancer stem-like phenotype

乳球形成 RNAi 筛选表明 ATG4A 促进乳腺癌干细胞样表型

Jonas Wolf, Dyah Laksmi Dewi, Johannes Fredebohm, Karin Müller-Decker, Christa Flechtenmacher, Jörg D Hoheisel, Michael Boettcher