日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Lentiviral vectors for hematopoietic stem cell gene therapy restore α-globin expression in α-thalassemia red blood cells

用于造血干细胞基因治疗的慢病毒载体可恢复α-地中海贫血红细胞中α-珠蛋白的表达

Eva E R Segura ,Kevyn Hart ,Beatriz Campo Fernandez ,Devin Brown ,Kevin Tam ,Andrea Gutierrez Garcia ,Eva Seigneurbieux ,Karen Li ,Carol Mulumba ,Emma Blakely ,Katelyn Masiuk ,Roshani Sinha ,Devesh Sharma ,John Everett ,Matthew Hogenauer ,M Kyle Cromer ,Frederic Bushman ,Tippi C MacKenzie ,Donald B Kohn

Effective gene therapy for metachromatic leukodystrophy achieved with minimal lentiviral genomic integrations

利用最小的慢病毒基因组整合实现对异染性脑白质营养不良的有效基因治疗

Lucas Tricoli ,Sunetra Sase ,Julia L Hacker ,Vi Pham ,Maxwell Chappell ,Laura Breda ,Stephanie N Hurwitz ,Naoto Tanaka ,Carlo Castruccio Castracani ,Amaliris Guerra ,Zhongqi Hou ,Lars Schlotawa ,Karthikeyan Radhakrishnan ,Matthew Hogenauer ,Aoife Roche ,John Everett ,Frederic Bushman ,Peter Kurre ,Rebecca Ahrens-Nicklas ,Laura A Adang ,Adeline L Vanderver ,Stefano Rivella

Partial ORF1ab Gene Target Failure with Omicron BA.2.12.1

Omicron BA.2.12.1 导致 ORF1ab 基因部分靶向失败

Kyle G Rodino, David R Peaper, Brendan J Kelly, Frederic Bushman, Andrew Marques, Hriju Adhikari, Zheng Jin Tu, Rebecca Marrero Rolon, Lars F Westblade, Daniel A Green, Gregory J Berry, Fann Wu, Medini K Annavajhala, Anne-Catrin Uhlemann, Bijal A Parikh, Tracy McMillen, Krupa Jani, N Esther Babady, 

Gut microbiota modulate dendritic cell antigen presentation and radiotherapy-induced antitumor immune response

肠道微生物群调节树突状细胞抗原呈递和放射治疗诱导的抗肿瘤免疫反应

Mireia Uribe-Herranz, Stavros Rafail, Silvia Beghi, Luis Gil-de-Gómez, Ioannis Verginadis, Kyle Bittinger, Sergey Pustylnikov, Stefano Pierini, Renzo Perales-Linares, Ian A Blair, Clementina A Mesaros, Nathaniel W Snyder, Frederic Bushman, Constantinos Koumenis, Andrea Facciabene

Sialylation and fucosylation modulate inflammasome-activating eIF2 Signaling and microbial translocation during HIV infection

唾液酸化和岩藻糖基化调节 HIV 感染期间炎症小体激活的 eIF2 信号传导和微生物易位

Leila B Giron, Ceylan E Tanes, Mariane H Schleimann, Phillip A Engen, Lisa M Mattei, Alitzel Anzurez, Mohammad Damra, Huanjia Zhang, Kyle Bittinger, Frederic Bushman, Andrew Kossenkov, Paul W Denton, Hiroaki Tateno, Ali Keshavarzian, Alan L Landay, Mohamed Abdel-Mohsen

A screen of Crohn's disease-associated microbial metabolites identifies ascorbate as a novel metabolic inhibitor of activated human T cells

对克罗恩病相关微生物代谢产物的筛选发现,抗坏血酸是一种新型的活化人T细胞代谢抑制剂。

Yu-Ling Chang ,Maura Rossetti ,Hera Vlamakis ,David Casero ,Gemalene Sunga ,Nicholas Harre ,Shelley Miller ,Romney Humphries ,Thaddeus Stappenbeck ,Kenneth W Simpson ,R Balfour Sartor ,Gary Wu ,James Lewis ,Frederic Bushman ,Dermot P B McGovern ,Nita Salzman ,James Borneman ,Ramnik Xavier ,Curtis Huttenhower ,Jonathan Braun

Transient Expression of an LEDGF/p75 Chimera Retargets Lentivector Integration and Functionally Rescues in a Model for X-CGD

LEDGF/p75 嵌合体的瞬时表达重新定位慢病毒载体整合并在 X-CGD 模型中进行功能性拯救

Sofie Vets, Jan De Rijck, Christian Brendel, Manuel Grez, Frederic Bushman, Zeger Debyser, Rik Gijsbers