Co-targeting BCL-XL and MCL-1 with DT2216 and AZD8055 synergistically inhibit small-cell lung cancer growth without causing on-target toxicities in mice
将 BCL-XL 和 MCL-1 与 DT2216 和 AZD8055 共同靶向可协同抑制小细胞肺癌生长，且不会在小鼠中引起靶向毒性
期刊:Cell Death Discovery
影响因子:6.1
doi:10.1038/s41420-022-01296-8
Sajid Khan, Patrick Kellish, Nick Connis, Dinesh Thummuri, Janet Wiegand, Peiyi Zhang, Xuan Zhang, Vivekananda Budamagunta, Nan Hua, Yang Yang, Umasankar De, Lingtao Jin, Weizhou Zhang, Guangrong Zheng, Robert Hromas, Christine Hann, Maria Zajac-Kaye, Frederic J Kaye, Daohong Zhou
