日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Using the Simcyp R Package for PBPK Simulation Workflows With the Simcyp Simulator

使用 Simcyp R 包和 Simcyp 模拟器进行 PBPK 模拟工作流程

Onasanwo, Anthonia M; Mittapelly, Naresh; Shireman, Laura; Vinden, Barry; McNally, Kevin; Craig, James; Bois, Frederic Y

A 100 Gb s(-1) quantum-confined Stark effect modulator monolithically integrated with silicon nitride on Si

一种单片集成在氮化硅衬底上的100 Gb s⁻¹量子限制斯塔克效应调制器

Skandalos, Ilias; Bucio, Thalía Domínguez; Mastronardi, Lorenzo; Yu, Guomin; Zilkie, Aaron; Gardes, Frederic Y

Evolutionary engineering of methylotrophic E. coli enables fast growth on methanol

甲基营养大肠杆菌的进化工程使其能够在甲醇上快速生长

Liang-Yu Nieh #, Frederic Y-H Chen #, Hsin-Wei Jung, Kuan-Yu Su, Chao-Yin Tsuei, Chun-Ting Lin, Yue-Qi Lee, James C Liao

Mapping Interindividual Variability of Toxicodynamics Using High-Throughput Transcriptomics and Primary Human Hepatocytes from Fifty Donors.

利用高通量转录组学和来自 50 位供体的原代人肝细胞绘制毒物动力学个体间差异图谱

Niemeijer Marije, Więcek Witold, Fu Shuai, Huppelschoten Suzanna, Bouwman Peter, Baze Audrey, Parmentier Céline, Richert Lysiane, Paules Richard S, Bois Frederic Y, van de Water Bob

Applications of the Cholesterol Metabolite, 4β-Hydroxycholesterol, as a Sensitive Endogenous Biomarker for Hepatic CYP3A Activity Evaluated within a PBPK Framework

在生理药代动力学框架下评估胆固醇代谢产物4β-羟基胆固醇作为肝脏CYP3A活性敏感内源性生物标志物的应用

Karkhanis, Aneesh V; Harwood, Matthew D; Stader, Felix; Bois, Frederic Y; Neuhoff, Sibylle

A Bayesian framework for virtual comparative trials and bioequivalence assessments

基于贝叶斯框架的虚拟比较试验和生物等效性评价

Bois, Frederic Y; Brochot, Céline

A guide to developing population files for physiologically-based pharmacokinetic modeling in the Simcyp Simulator

Simcyp模拟器中基于生理的药代动力学建模的人群文件开发指南

Curry, Liam; Alrubia, Sarah; Bois, Frederic Y; Clayton, Ruth; El-Khateeb, Eman; Johnson, Trevor N; Faisal, Muhammad; Neuhoff, Sibylle; Wragg, Kris; Rostami-Hodjegan, Amin

Author Correction: An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria

作者更正:一种对ATP敏感的磷酸酮酶调节蓝细菌中的碳固定作用

Lu, Kuan-Jen; Chang, Chiung-Wen; Wang, Chun-Hsiung; Chen, Frederic Y-H; Huang, Irene Y; Huang, Pin-Hsuan; Yang, Cheng-Han; Wu, Hsiang-Yi; Wu, Wen-Jin; Hsu, Kai-Cheng; Ho, Meng-Chiao; Tsai, Ming-Daw; Liao, James C

An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria

ATP 敏感的磷酸酮醇酶调节蓝藻中的碳固定

Kuan-Jen Lu #, Chiung-Wen Chang #, Chun-Hsiung Wang, Frederic Y-H Chen, Irene Y Huang, Pin-Hsuan Huang, Cheng-Han Yang, Hsiang-Yi Wu, Wen-Jin Wu, Kai-Cheng Hsu, Meng-Chiao Ho, Ming-Daw Tsai, James C Liao

Understanding Discordance between In Vitro Dissolution, Local Gut and Systemic Bioequivalence of Budesonide in Healthy and Crohn's Disease Patients through PBPK Modeling

通过PBPK模型了解布地奈德在健康人和克罗恩病患者体内体外溶出度、局部肠道和全身生物等效性之间的差异

Han, Chunyan; Sun, Tiancheng; Chirumamilla, Siri Kalyan; Bois, Frederic Y; Xu, Mandy; Rostami-Hodjegan, Amin