日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Dual targeting of CD19 and CD22 with bicistronic CAR-T cells in patients with relapsed/refractory large B-cell lymphoma

利用双顺反子CAR-T细胞双重靶向CD19和CD22治疗复发/难治性大B细胞淋巴瘤患者

Roddie, Claire; Lekakis, Lazaros J; Marzolini, Maria A V; Ramakrishnan, Aravind; Zhang, Yiyun; Hu, Yanqing; Peddareddigari, Vijay G R; Khokhar, Nushmia; Chen, Robert; Basilico, Silvia; Raymond, Meera; Vargas, Frederick Arce; Duffy, Kevin; Brugger, Wolfram; O'Reilly, Maeve A; Wood, Leigh; Linch, David C; Peggs, Karl S; Bachier, Carlos; Budde, Elizabeth Lihua; Lee Batlevi, Connie; Bartlett, Nancy; Irvine, David; Tholouli, Eleni; Osborne, Wendy; Ardeshna, Kirit M; Pule, Martin A

CAR T cells with dual targeting of CD19 and CD22 in pediatric and young adult patients with relapsed or refractory B cell acute lymphoblastic leukemia: a phase 1 trial

针对复发或难治性B细胞急性淋巴细胞白血病患儿及青少年患者的CD19和CD22双重靶向CAR-T细胞:一项I期临床试验

Shaun Cordoba # ,Shimobi Onuoha # ,Simon Thomas # ,Daniela Soriano Pignataro ,Rachael Hough ,Sara Ghorashian ,Ajay Vora ,Denise Bonney ,Paul Veys ,Kanchan Rao ,Giovanna Lucchini ,Robert Chiesa ,Jan Chu ,Liz Clark ,Mei Mei Fung ,Koval Smith ,Carlotta Peticone ,Muhammad Al-Hajj ,Vania Baldan ,Mathieu Ferrari ,Saket Srivastava ,Ram Jha ,Frederick Arce Vargas ,Kevin Duffy ,William Day ,Paul Virgo ,Lucy Wheeler ,Jeremy Hancock ,Farzin Farzaneh ,Sabine Domning ,Yiyun Zhang ,Nushmia Z Khokhar ,Vijay G R Peddareddigari ,Robert Wynn ,Martin Pule ,Persis J Amrolia

Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4+ T Cells

调节性T细胞抑制CD4+ T细胞通过白细胞介素-2和Blimp-1依赖性途径获得细胞毒性功能

Anna Śledzińska ,Maria Vila de Mucha ,Katharina Bergerhoff ,Alastair Hotblack ,Dafne Franz Demane ,Ehsan Ghorani ,Ayse U Akarca ,Maria A V Marzolini ,Isabelle Solomon ,Frederick Arce Vargas ,Martin Pule ,Masahiro Ono ,Benedict Seddon ,George Kassiotis ,Charlotte E Ariyan ,Thomas Korn ,Teresa Marafioti ,Graham M Lord ,Hans Stauss ,Richard G Jenner ,Karl S Peggs ,Sergio A Quezada

CD25-Treg-depleting antibodies preserving IL-2 signaling on effector T cells enhance effector activation and antitumor immunity

CD25-Treg 耗竭抗体保留效应 T 细胞上的 IL-2 信号传导,增强效应活化和抗肿瘤免疫

Isabelle Solomon, Maria Amann, Anne Goubier, Frederick Arce Vargas, Dimitrios Zervas, Chen Qing, Jake Y Henry, Ehsan Ghorani, Ayse U Akarca, Teresa Marafioti, Anna Śledzińska, Mariana Werner Sunderland, Dafne Franz Demane, Joanne Ruth Clancy, Andrew Georgiou, Josephine Salimu, Pascal Merchiers, Mark

Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies

Fc效应功能有助于人抗CTLA-4抗体的活性

Frederick Arce Vargas ,Andrew J S Furness ,Kevin Litchfield ,Kroopa Joshi ,Rachel Rosenthal ,Ehsan Ghorani ,Isabelle Solomon ,Marta H Lesko ,Nora Ruef ,Claire Roddie ,Jake Y Henry ,Lavinia Spain ,Assma Ben Aissa ,Andrew Georgiou ,Yien Ning Sophia Wong ,Myles Smith ,Dirk Strauss ,Andrew Hayes ,David Nicol ,Tim O'Brien ,Linda Mårtensson ,Anne Ljungars ,Ingrid Teige ,Björn Frendéus ,Teresa Marafioti ,Martin Gore ,James Larkin ,Samra Turajlic ,Charles Swanton ,Karl S Peggs ,Sergio A Quezada

Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors

Fc 优化的抗 CD25 可消耗肿瘤浸润调节性 T 细胞并与 PD-1 阻断剂协同作用以根除已建立的肿瘤

Frederick Arce Vargas, Andrew J S Furness, Isabelle Solomon, Kroopa Joshi, Leila Mekkaoui, Marta H Lesko, Enrique Miranda Rota, Rony Dahan, Andrew Georgiou, Anna Sledzinska, Assma Ben Aissa, Dafne Franz, Mariana Werner Sunderland, Yien Ning Sophia Wong, Jake Y Henry, Tim O'Brien, David Nicol, Ben Ch

The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2

TRAIL诱导的癌细胞分泌组通过CCR2促进肿瘤支持性免疫微环境的形成

Torsten Hartwig ,Antonella Montinaro ,Silvia von Karstedt ,Alexandra Sevko ,Silvia Surinova ,Ankur Chakravarthy ,Lucia Taraborrelli ,Peter Draber ,Elodie Lafont ,Frederick Arce Vargas ,Mona A El-Bahrawy ,Sergio A Quezada ,Henning Walczak

Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma

Fc 依赖性肿瘤浸润调节性 T 细胞的消耗共同决定了抗 CTLA-4 治疗黑色素瘤的疗效

Tyler R Simpson, Fubin Li, Welby Montalvo-Ortiz, Manuel A Sepulveda, Katharina Bergerhoff, Frederick Arce, Claire Roddie, Jake Y Henry, Hideo Yagita, Jedd D Wolchok, Karl S Peggs, Jeffrey V Ravetch, James P Allison, Sergio A Quezada

Selective ERK activation differentiates mouse and human tolerogenic dendritic cells, expands antigen-specific regulatory T cells, and suppresses experimental inflammatory arthritis

选择性 ERK 激活可分化小鼠和人类耐受性树突状细胞、扩增抗原特异性调节性 T 细胞并抑制实验性炎症性关节炎

Frederick Arce, Karine Breckpot, Holly Stephenson, Katarzyna Karwacz, Michael R Ehrenstein, Mary Collins, David Escors

PD-L1 co-stimulation contributes to ligand-induced T cell receptor down-modulation on CD8+ T cells

PD-L1 共刺激导致 CD8+ T 细胞上配体诱导的 T 细胞受体下调

Katarzyna Karwacz, Christopher Bricogne, Douglas MacDonald, Frederick Arce, Clare L Bennett, Mary Collins, David Escors