日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Molecular basis for differential Igk versus Igh V(D)J joining mechanisms

差异化 Igk 与 Igh V(D)J 连接机制的分子基础

Yiwen Zhang #, Xiang Li #, Zhaoqing Ba, Jiangman Lou, K Elyse Gaertner, Tammie Zhu, Xin Lin, Adam Yongxin Ye, Frederick W Alt, Hongli Hu #

Vaccination induces broadly neutralizing antibody precursors to HIV gp41

接种疫苗可诱导产生针对 HIV gp41 的广谱中和抗体前体

Torben Schiffner # ,Ivy Phung # ,Rashmi Ray # ,Adriana Irimia # ,Ming Tian # ,Olivia Swanson ,Jeong Hyun Lee ,Chang-Chun D Lee ,Ester Marina-Zárate ,So Yeon Cho ,Jiachen Huang ,Gabriel Ozorowski ,Patrick D Skog ,Andreia M Serra ,Kimmo Rantalainen ,Joel D Allen ,Sabyasachi Baboo ,Oscar L Rodriguez ,Sunny Himansu ,Jianfu Zhou ,Jonathan Hurtado ,Claudia T Flynn ,Katherine McKenney ,Colin Havenar-Daughton ,Swati Saha ,Kaitlyn Shields ,Steven Schultze ,Melissa L Smith ,Chi-Hui Liang ,Laura Toy ,Simone Pecetta ,Ying-Cing Lin ,Jordan R Willis ,Fabian Sesterhenn ,Daniel W Kulp ,Xiaozhen Hu ,Christopher A Cottrell ,Xiaoya Zhou ,Jennifer Ruiz ,Xuesong Wang ,Usha Nair ,Kathrin H Kirsch ,Hwei-Ling Cheng ,Jillian Davis ,Oleksandr Kalyuzhniy ,Alessia Liguori ,Jolene K Diedrich ,Julia T Ngo ,Vanessa Lewis ,Nicole Phelps ,Ryan D Tingle ,Skye Spencer ,Erik Georgeson ,Yumiko Adachi ,Michael Kubitz ,Saman Eskandarzadeh ,Marc A Elsliger ,Rama R Amara ,Elise Landais ,Bryan Briney ,Dennis R Burton ,Diane G Carnathan ,Guido Silvestri ,Corey T Watson ,John R Yates 3rd ,James C Paulson ,Max Crispin ,Gevorg Grigoryan ,Andrew B Ward ,Devin Sok ,Frederick W Alt ,Ian A Wilson ,Facundo D Batista ,Shane Crotty ,William R Schief

Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site

针对种系HIV疫苗接种可诱导产生针对CD4结合位点的中和抗体

Tom G Caniels ,Max Medina-Ramìrez ,Shiyu Zhang ,Sven Kratochvil ,Yuejiao Xian ,Ja-Hyun Koo ,Ronald Derking ,Jakob Samsel ,Jelle van Schooten ,Simone Pecetta ,Edward Lamperti ,Meng Yuan ,María Ríos Carrasco ,Iván Del Moral Sánchez ,Joel D Allen ,Joey H Bouhuijs ,Anila Yasmeen ,Thomas J Ketas ,Jonne L Snitselaar ,Tom P L Bijl ,Isabel Cuella Martin ,Jonathan L Torres ,Albert Cupo ,Lisa Shirreff ,Kenneth Rogers ,Rosemarie D Mason ,Mario Roederer ,Kelli M Greene ,Hongmei Gao ,Catarina Mendes Silva ,Isabel J L Baken ,Ming Tian ,Frederick W Alt ,Bali Pulendran ,Michael S Seaman ,Max Crispin ,Marit J van Gils ,David C Montefiori ,Adrian B McDermott ,François J Villinger ,Richard A Koup ,John P Moore ,Per Johan Klasse ,Gabriel Ozorowski ,Facundo D Batista ,Ian A Wilson ,Andrew B Ward ,Rogier W Sanders

Comparison of the immunogenicity of mRNA-encoded and protein HIV-1 Env-ferritin nanoparticle designs

比较mRNA编码和蛋白质HIV-1 Env-铁蛋白纳米颗粒设计的免疫原性

Zekun Mu ,Jill Whitley ,Diana Martik ,Laura Sutherland ,Amanda Newman ,Maggie Barr ,Robert Parks ,Kevin Wiehe ,Derek W Cain ,Katrina Z Hodges ,Sravani Venkatayogi ,Esther M Lee ,Lena Smith ,Katayoun Mansouri ,Robert J Edwards ,Yunfei Wang ,Wes Rountree ,Mohamad-Gabriel Alameh ,Ying Tam ,Christopher Barbosa ,Mark Tomai ,Mark G Lewis ,Sampa Santrai ,Maureen Maughan ,Ming Tian ,Frederick W Alt ,Drew Weissman ,Kevin O Saunders ,Barton F Haynes

Orientation Regulation of Class-switch Recombination in Human B Cells

人类 B 细胞类别转换重组的方向调控

Likun Du, Valentyn Oksenych, Hui Wan, Xiaofei Ye, Junchao Dong, Adam Yongxin Ye, Hassan Abolhassani, Stelios Vlachiotis, Xuefei Zhang, Kathrin de la Rosa, Lennart Hammarström, Mirjam van der Burg, Frederick W Alt, Qiang Pan-Hammarström

Structural principles of B cell antigen receptor assembly

细胞抗原受体组装的结构原理

Ying Dong #, Xiong Pi #, Frauke Bartels-Burgahn, Deniz Saltukoglu, Zhuoyi Liang, Jianying Yang, Frederick W Alt, Michael Reth, Hao Wu

An antibody from single human VH-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion

来自单个人类VH重排小鼠的抗体可通过抑制膜融合,中和所有经BA.5途径感染的SARS-CoV-2变异株。

Sai Luo ,Jun Zhang ,Alex J B Kreutzberger ,Amanda Eaton ,Robert J Edwards ,Changbin Jing ,Hai-Qiang Dai ,Gregory D Sempowski ,Kenneth Cronin ,Robert Parks ,Adam Yongxin Ye ,Katayoun Mansouri ,Maggie Barr ,Novalia Pishesha ,Aimee Chapdelaine Williams ,Lucas Vieira Francisco ,Anand Saminathan ,Hanqin Peng ,Himanshu Batra ,Lorenza Bellusci ,Surender Khurana ,S Munir Alam ,David C Montefiori ,Kevin O Saunders ,Ming Tian ,Hidde Ploegh ,Tom Kirchhausen ,Bing Chen ,Barton F Haynes ,Frederick W Alt

SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination

SHLD1对于53BP1依赖的V(D)J重组并非必需,但对于有效的类别转换重组至关重要。

Estelle Vincendeau ,Wenming Wei ,Xuefei Zhang ,Cyril Planchais ,Wei Yu ,Hélène Lenden-Hasse ,Thomas Cokelaer ,Juliana Pipoli da Fonseca ,Hugo Mouquet ,David J Adams ,Frederick W Alt ,Stephen P Jackson ,Gabriel Balmus ,Chloé Lescale ,Ludovic Deriano

C-terminal deletion-induced condensation sequesters AID from IgH targets in immunodeficiency

端缺失诱导的缩合隔离物可与免疫缺陷中的 IgH 靶标结合

Xia Xie #, Tingting Gan #, Bing Rao #, Weiwei Zhang, Rohit A Panchakshari, Dingpeng Yang, Xiong Ji, Yu Cao, Frederick W Alt, Fei-Long Meng, Jiazhi Hu

mRNA-encoded HIV-1 Env trimer ferritin nanoparticles induce monoclonal antibodies that neutralize heterologous HIV-1 isolates in mice

mRNA编码的HIV-1 Env三聚体铁蛋白纳米颗粒可诱导产生单克隆抗体,这些抗体能够中和小鼠体内的异源HIV-1分离株。

Zekun Mu,Kevin Wiehe,Kevin O Saunders,Rory Henderson,Derek W Cain,Robert Parks,Diana Martik,Katayoun Mansouri,Robert J Edwards,Amanda Newman,Xiaozhi Lu,Shi-Mao Xia,Amanda Eaton,Mattia Bonsignori,David Montefiori,Qifeng Han,Sravani Venkatayogi,Tyler Evangelous,Yunfei Wang,Wes Rountree,Bette Korber,Kshitij Wagh,Ying Tam,Christopher Barbosa,S Munir Alam,Wilton B Williams,Ming Tian,Frederick W Alt,Norbert Pardi,Drew Weissman,Barton F Haynes