Free R Benjamin相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

Discovery, Characterization, and Optimization of a Novel Positive Allosteric Modulator-Antagonist of the D(3) Dopamine Receptor.

发现、表征和优化一种新型的D(3)多巴胺受体正向变构调节剂-拮抗剂

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.5c01585

Moritz Amy E, Wang Feijun, Madaras Nora S, Kelley Amber M, Snyder Kirsten K, Gandhi Disha, Inbody Laura R, Akano Emmanuel O, Shi Lei, Lane J Robert, Free R Benjamin, Frankowski Kevin J, Sibley David R

发表日期：2025

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Multiple Allosteric Sites Allow for Synergistic Enhancement of GPCR Signaling

多个变构位点可协同增强GPCR信号传导

doi:10.1101/2025.10.21.683604

Wang, Kai; Dimova, Snezana T; Hanson, John N; Thakur, Abhishek; Xu, Youwei; Liu, Yini; Moritz, Amy E; Goldberg, Alexander; Xie, Bing; Rayadurgam, Jayachandra; Wang, Feijun; Nilson, Ashley N; Luderman, Kathryn D; Free, R Benjamin; Hu, Wen; Zhang, Jian; Xu, H Eric; Frankowski, Kevin J; Wang, Yue; Shi, Lei; Sibley, David R; Zhuang, Youwen

GPCR/Calcium/cAMP

发表日期：2025

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Novel Cryo-EM structures of the D1 dopamine receptor unlock its therapeutic potential

D1多巴胺受体的新型冷冻电镜结构揭示了其治疗潜力

期刊:Signal Transduction and Targeted Therapy

影响因子:52.7

doi:10.1038/s41392-021-00630-3

Sibley, David R; Luderman, Kathryn D; Free, R Benjamin; Shi, Lei

发表日期：2021

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New roles for dopamine D(2) and D(3) receptors in pancreatic beta cell insulin secretion

多巴胺D(2)和D(3)受体在胰岛β细胞胰岛素分泌中的新作用

期刊:Molecular Psychiatry

影响因子:10.1

doi:10.1038/s41380-018-0344-6

Farino, Zachary J; Morgenstern, Travis J; Maffei, Antonella; Quick, Matthias; De Solis, Alain J; Wiriyasermkul, Pattama; Freyberg, Robin J; Aslanoglou, Despoina; Sorisio, Denise; Inbar, Benjamin P; Free, R Benjamin; Donthamsetti, Prashant; Mosharov, Eugene V; Kellendonk, Christoph; Schwartz, Gary J; Sibley, David R; Schmauss, Claudia; Zeltser, Lori M; Moore, Holly; Harris, Paul E; Javitch, Jonathan A; Freyberg, Zachary

细胞生物学

免疫/内分泌

发表日期：2020

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A structural basis for how ligand binding site changes can allosterically regulate GPCR signaling and engender functional selectivity

配体结合位点变化如何通过变构调节GPCR信号传导并产生功能选择性的结构基础

期刊:Science Signaling

影响因子:6.6

doi:10.1126/scisignal.aaw5885

Sanchez-Soto, Marta; Verma, Ravi Kumar; Willette, Blair K A; Gonye, Elizabeth C; Moore, Annah M; Moritz, Amy E; Boateng, Comfort A; Yano, Hideaki; Free, R Benjamin; Shi, Lei; Sibley, David R

GPCR/Calcium/cAMP

发表日期：2020

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Advances and challenges in the search for D(2) and D(3) dopamine receptor-selective compounds

D(2)和D(3)多巴胺受体选择性化合物的研究进展与挑战

期刊:Cellular Signalling

影响因子:3.7

doi:10.1016/j.cellsig.2017.07.003

Moritz, Amy E; Free, R Benjamin; Sibley, David R

发表日期：2018

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Identification of Positive Allosteric Modulators of the D(1) Dopamine Receptor That Act at Diverse Binding Sites

鉴定作用于不同结合位点的D(1)多巴胺受体正向变构调节剂

期刊:Molecular Pharmacology

doi:10.1124/mol.118.113175

Luderman, Kathryn D; Conroy, Jennie L; Free, R Benjamin; Southall, Noel; Ferrer, Marc; Sanchez-Soto, Marta; Moritz, Amy E; Willette, Blair K A; Fyfe, Tim J; Jain, Prashi; Titus, Steve; Hazelwood, Lisa A; Aubé, Jeffrey; Lane, J Robert; Frankowski, Kevin J; Sibley, David R

发表日期：2018

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Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D(3) Receptor (D(3)R)

合成和药理学表征新型反式环丙基甲基连接的二价配体，该配体在多巴胺D(3)受体(D(3)R)上表现出选择性和变构药理学作用

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.6b01688

Kumar, Vivek; Moritz, Amy E; Keck, Thomas M; Bonifazi, Alessandro; Ellenberger, Michael P; Sibley, Christopher D; Free, R Benjamin; Shi, Lei; Lane, J Robert; Sibley, David R; Newman, Amy Hauck

发表日期：2017

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Investigation of the binding and functional properties of extended length D3 dopamine receptor-selective antagonists

对长链D3多巴胺受体选择性拮抗剂的结合和功能特性进行研究

期刊:European Neuropsychopharmacology

影响因子:6.7

doi:10.1016/j.euroneuro.2014.11.013

Furman, Cheryse A; Roof, Rebecca A; Moritz, Amy E; Miller, Brittney N; Doyle, Trevor B; Free, R Benjamin; Banala, Ashwini K; Paul, Noel M; Kumar, Vivek; Sibley, Christopher D; Newman, Amy Hauck; Sibley, David R

发表日期：2015

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Identification of G protein-biased agonists that fail to recruit β-arrestin or promote internalization of the D1 dopamine receptor

鉴定那些不能募集β-arrestin或促进D1多巴胺受体内化的G蛋白偏向性激动剂

期刊:ACS Chemical Neuroscience

影响因子:3.9

doi:10.1021/acschemneuro.5b00020

Conroy, Jennie L; Free, R Benjamin; Sibley, David R

发表日期：2015

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