Hepatocyte MLKL Drives Obesity-Driven Hepatocellular Carcinoma Progression via Mitochondrial Dysfunction Independent of Necroptosis in MASLD
在MASLD中,肝细胞MLKL通过线粒体功能障碍驱动肥胖相关的肝细胞癌进展,且该过程独立于坏死性凋亡。
期刊:
影响因子:
doi:10.1101/2025.11.26.690789
Ohene-Marfo, Phoebe; Mohammed, Sabira; Jiang, Chao; Bhaskaran, Shylesh; Georgescu, Constantin; John, Megan; Pham, Kevin; Tran, Albert; Rao, Chinthalapally V; Gyu Oh, Tae; Kinter, Michael; Freeman, Willard M; Houchen, Courtney; Wren, Jonathan D; Deepa, Sathyaseelan S
肿瘤
凋亡
表观遗传
肿瘤免疫
代谢
MLKL
肥胖
线粒体
细胞生物学