日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Activation of IRF3 in cardiomyocytes impairs mitochondrial oxidative function through PGC-1α inhibition and drives heart failure.

心肌细胞中 IRF3 的激活通过抑制 PGC-1α 损害线粒体氧化功能，从而导致心力衰竭。

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-026-69792-4
Kumari Manju, Evangelakos Ioannis, Deshpande Anushka, De Jong Kirstie A, Schmiedel Nesrin, Palacio-Escat Nicolàs, Chaves-Filho Adriano de Britto, Frias-Soler Roberto Carlos, Klinke Glynis, Roh Hyun Cheol, Lange Luisa, Berlin Michael, Fuh Marceline M, Buss Jakob Johannes, Tian Tian, Lerchenmüller Carolin, Freichel Marc, Schulze Almut, Nikolaev Viacheslav O, Eschenhagen Thomas, Rosen Evan D, Scheja Ludger, Rangrez Ashraf Yusuf, Heeren Joerg, Frey Norbert
心力衰竭
细胞生物学
IRF3
线粒体
发表日期：2026
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Sarcomeric remodelling in human heart failure unraveled by single molecule long read sequencing

利用单分子长读长测序揭示人类心力衰竭中的肌节重塑

期刊:EMBO Molecular Medicine
影响因子:
doi:10.1038/s44321-025-00370-9
Haas, Jan; Schudy, Sarah; Rauscher, Benedikt; Muñoz Verdú, Ana; Roßkopf, Steffen; Reich, Christoph; Donmez Yalcin, Gizem; Yalcin, Abdullah; Seeger, Timon; Dieterich, Christoph; Taft, Manuel H; Freichel, Marc; Grimm, Dirk; Manstein, Dietmar; Backs, Johannes; Frey, Norbert; Steinmetz, Lars; Meder, Benjamin
心力衰竭
心血管
发表日期：2026
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ABE9 fused to SpRY Cas9 nickase enables precise generation of bystander free mouse models

ABE9 与 SpRY Cas9 切口酶融合，可实现精确构建无旁观者效应的小鼠模型。

期刊:Scientific Reports
影响因子:
doi:10.1038/s41598-026-40642-z
Ong, Jun Kai; Bhunia, Sayari; Hilbert, Beate; Kirschner, Vanessa; Duglosz, Sascha; Zimmermann, Frank; Freichel, Marc; Cornean, Alex
发表日期：2026
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Adenosine-Specific Transcriptional Programs in Murine Connective Tissue-Type Mast Cells

小鼠结缔组织型肥大细胞中腺苷特异性转录程序

期刊:ACS Pharmacology and Translational Science
影响因子:
doi:10.1021/acsptsci.5c00741
Liang, Qihua; Tsvilovskyy, Volodymyr; Belkacemi, Anouar; Bukva, Merima; Richter, Christin; Ludwig, Nicole; Keller, Andreas; Freichel, Marc
细胞生物学
肥大细胞
发表日期：2026
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S100A1ct: A Synthetic Peptide Derived From S100A1 Protein Improves Cardiac Performance and Survival in Preclinical Heart Failure Models

S100A1ct：一种源自S100A1蛋白的合成肽可改善临床前心力衰竭模型的心脏功能和生存率

期刊:Circulation
影响因子:38.6
doi:10.1161/CIRCULATIONAHA.123.066961
Kehr, Dorothea; Ritterhoff, Julia; Glaser, Manuel; Jarosch, Lukas; Salazar, Rafael E; Spaich, Kristin; Varadi, Karl; Birkenstock, Jennifer; Egger, Michael; Gao, Erhe; Koch, Walter J; Sauter, Max; Freichel, Marc; Katus, Hugo A; Frey, Norbert; Jungmann, Andreas; Busch, Cornelius; Mather, Paul J; Ruhparwar, Arjang; Busch, Martin; Völkers, Mirko; Wade, Rebecca C; Most, Patrick
心力衰竭
心血管
发表日期：2025
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Call for Papers – Purinergic Signaling: Medicinal Chemistry, Biology, Pharmacology, and Translation into Diagnostic and Therapeutic Drugs

征稿启事——嘌呤能信号传导：药物化学、生物学、药理学及其在诊断和治疗药物中的转化应用

期刊:Journal of Nanobiotechnology
影响因子:12.6
doi:10.1186/s12951-024-02603-4
Yang, Song; Sun, Yiran; Yan, Chenchen; Müller, Christa E; Nicke, Annette; Lohr, Christian; Freichel, Marc; Guse, Andreas H
信号转导
发表日期：2025
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TRPV6 channel function is involved in endometrial epithelial cell Ca(2+) signaling and female mouse fecundity

TRPV6通道功能参与子宫内膜上皮细胞Ca(2+)信号传导和雌性小鼠的繁殖力。

期刊:Cellular and Molecular Life Sciences
影响因子:6.2
doi:10.1007/s00018-025-05857-9
Sota, Adela; Beck, Andreas; Wartenberg, Philipp; Gehl, Anna-Lena; Winter, Manuel; Wissenbach, Ulrich; Freichel, Marc; Meyer, Markus R; Boehm, Ulrich; Flockerzi, Veit; Fecher-Trost, Claudia; Weissgerber, Petra
上皮细胞
信号转导
细胞生物学
发表日期：2025
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Inactivation of cofilin-1 in Mcpt5-Cre-nf-Cfl1(fl/fl) mice prevents the formation of connective tissue mast cells without affecting basophils: a new tool to investigate the specific role of CTMCs in disease

在Mcpt5-Cre-nf-Cfl1(fl/fl)小鼠中，cofilin-1的失活可阻止结缔组织肥大细胞的形成，而不影响嗜碱性粒细胞：这是研究CTMC在疾病中具体作用的新工具。

期刊:Frontiers in Immunology
影响因子:5.9
doi:10.3389/fimmu.2025.1671735
Kramer, Johanna; Schneider, Jakob; Liu, Huiying; Silva-Vilches, Cinthia; Moos, Sonja; Kamenjarin, Nadine; Hodapp, Katrin; Tsvilovskyy, Volodymyr; Freichel, Marc; Probst, Hans Christian; Mahnke, Karsten; Kurschus, Florian C; Samstag, Yvonne
细胞生物学
肥大细胞
粒细胞
发表日期：2025
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Investigating risk factor and consequence accounts of executive functioning impairments in psychopathology: an 8-year study of at-risk individuals in Brazil

探究精神病理学中执行功能障碍的风险因素和后果：一项针对巴西高危人群的8年研究

期刊:Psychological Medicine
影响因子:5.5
doi:10.1017/S0033291725100639
Freichel, René; Epskamp, Sacha; de Jong, Peter J; Cousijn, Janna; Franken, Ingmar; Salum, Giovanni A; Pan, Pedro Mario; Veer, Ilya M; Wiers, Reinout W
发表日期：2025
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Anxiety Symptom Severity and Implicit and Explicit Self-As-Anxious Associations in a Large Online Sample of U.S. Adults: Trends From 2011 to 2022

美国成年人大型在线样本中焦虑症状严重程度及内隐和外显的“自我即焦虑”联想：2011年至2022年的趋势

期刊:Clinical Psychological Science
影响因子:4.1
doi:10.1177/21677026251359621
French, Noah J; Freichel, René; Kahveci, Sercan; Werntz, Alexandra; Howell, Jennifer L; Lindgren, Kristen P; O'Shea, Brian A; Boker, Steven M; Teachman, Bethany A
焦虑症
神经科学
发表日期：2025
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