Ex vivo culture of Fancc-/- stem/progenitor cells predisposes cells to undergo apoptosis, and surviving stem/progenitor cells display cytogenetic abnormalities and an increased risk of malignancy
体外培养Fancc-/-干/祖细胞会使细胞易于发生凋亡,而存活的干/祖细胞则表现出细胞遗传学异常和恶性肿瘤风险增加。
期刊:Blood
影响因子:23.1
doi:10.1182/blood-2004-06-2483
Li, Xiaxin; Le Beau, Michelle M; Ciccone, Samantha; Yang, Feng-Chun; Freie, Brian; Chen, Shi; Yuan, Jin; Hong, Ping; Orazi, Attilio; Haneline, Laura S; Clapp, D Wade