DNA-encoded library screening uncovers potent DNMT2 inhibitors targeting a cryptic allosteric binding site.
DNA编码文库筛选发现了靶向隐蔽变构结合位点的强效DNMT2抑制剂
期刊:iScience
影响因子:4.1
doi:10.1016/j.isci.2025.113300
Frey Ariane F, Schwan Merlin, Weldert Annabelle C, Kadenbach Valerie, Kopp Jürgen, Nidoieva Zarina, Zimmermann Robert A, Gleue Lukas, Zimmer Collin, Jörg Marko, Friedland Kristina, Helm Mark, Sinning Irmgard, Barthels Fabian
