日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Preclinical development of ozuriftamab vedotin (BA3021), a novel ROR2-specific conditionally active biologic antibody-drug conjugate.

ozuriftamab vedotin (BA3021) 是一种新型 ROR2 特异性条件活性生物抗体药物偶联物,其临床前开发

Chang Hwai Wen, Frey Gerhard, Wang Jing, Liu Haizhen, Xing Charles, Chen Jian, Boyle William J, Short Jay M

Preclinical development of mecbotamab vedotin (BA3011), a novel, AXL-specific conditional active biologic antibody-drug conjugate.

mecbotamab vedotin (BA3011) 是一种新型的 AXL 特异性条件活性生物抗体药物偶联物,其临床前开发

Chang Hwai Wen, Wang Jing, Liu Haizhen, Xing Charles, Chen Jian, Frey Gerhard, Boyle William J, Short Jay M

Eosinophils preserve bone homeostasis by inhibiting excessive osteoclast formation and activity via eosinophil peroxidase

嗜酸性粒细胞通过嗜酸性粒细胞过氧化物酶抑制破骨细胞过度形成和活性,从而维持骨骼稳态。

Darja Andreev ,Katerina Kachler ,Mengdan Liu ,Zhu Chen ,Brenda Krishnacoumar ,Mark Ringer ,Silke Frey ,Gerhard Krönke ,David Voehringer ,Georg Schett ,Aline Bozec

A novel conditional active biologic anti-EpCAM x anti-CD3 bispecific antibody with synergistic tumor selectivity for cancer immunotherapy

一种新型条件性活性生物制剂抗EpCAM x 抗CD3双特异性抗体,具有协同肿瘤选择性,可用于癌症免疫治疗。

Frey, Gerhard; Cugnetti, Ana Paula G; Liu, Haizhen; Xing, Charles; Wheeler, Christina; Chang, Hwai Wen; Boyle, William J; Short, Jay M

Generating tumor-selective conditionally active biologic anti-CTLA4 antibodies via protein-associated chemical switches

通过蛋白质相关化学开关生成肿瘤选择性条件活性生物制剂抗CTLA4抗体

Chang, Hwai Wen; Frey, Gerhard; Liu, Haizhen; Xing, Charles; Steinman, Lawrence; Boyle, William J; Short, Jay M

Biocatalytic conversion of avermectin to 4''-oxo-avermectin: improvement of cytochrome p450 monooxygenase specificity by directed evolution

利用定向进化提高细胞色素P450单加氧酶的特异性,实现阿维菌素向4''-氧代阿维菌素的生物催化转化

Trefzer, Axel; Jungmann, Volker; Molnár, István; Botejue, Ajit; Buckel, Dagmar; Frey, Gerhard; Hill, D Steven; Jörg, Mario; Ligon, James M; Mason, Dylan; Moore, David; Pachlatko, J Paul; Richardson, Toby H; Spangenberg, Petra; Wall, Mark A; Zirkle, Ross; Stege, Justin T