日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Long-lasting B cell convergence to distinct broadly reactive epitopes following vaccination with chimeric influenza virus hemagglutinins

接种嵌合流感病毒血凝素后,B细胞会长期趋同于不同的广谱反应性表位。

Jenna J Guthmiller ,Linda Yu-Ling Lan ,Lei Li ,Yanbin Fu ,Sean A Nelson ,Carole Henry ,Christopher T Stamper ,Henry A Utset ,Alec W Freyn ,Julianna Han ,Olivia Stovicek ,Jiaolong Wang ,Nai-Ying Zheng ,Min Huang ,Haley L Dugan ,Micah E Tepora ,Xueyong Zhu ,Yao-Qing Chen ,Anna-Karin E Palm ,Dustin G Shaw ,Madhumathi Loganathan ,Benjamin F Francis ,Jiayi Sun ,Jordan Chervin ,Chloe Troxell ,Philip Meade ,Nancy H L Leung ,Sophie A Valkenburg ,Sarah Cobey ,Benjamin J Cowling ,Ian A Wilson ,Adolfo García-Sastre ,Raffael Nachbagauer ,Andrew B Ward ,Lynda Coughlan ,Florian Krammer ,Patrick C Wilson

Broadly neutralizing antibodies target a haemagglutinin anchor epitope

广谱中和抗体靶向血凝素锚表位

Jenna J Guthmiller #, Julianna Han #, Henry A Utset, Lei Li, Linda Yu-Ling Lan, Carole Henry, Christopher T Stamper, Meagan McMahon, George O'Dell, Monica L Fernández-Quintero, Alec W Freyn, Fatima Amanat, Olivia Stovicek, Lauren Gentles, Sara T Richey, Alba Torrents de la Peña, Victoria Rosado, Hal

Safety and immunogenicity of a ferritin nanoparticle H2 influenza vaccine in healthy adults: a phase 1 trial

铁蛋白纳米颗粒H2流感疫苗在健康成人中的安全性和免疫原性:一项I期试验

Houser, Katherine V; Chen, Grace L; Carter, Cristina; Crank, Michelle C; Nguyen, Thuy A; Burgos Florez, Maria Claudia; Berkowitz, Nina M; Mendoza, Floreliz; Hendel, Cynthia Starr; Gordon, Ingelise J; Coates, Emily E; Vazquez, Sandra; Stein, Judy; Case, Christopher L; Lawlor, Heather; Carlton, Kevin; Gaudinski, Martin R; Strom, Larisa; Hofstetter, Amelia R; Liang, C Jason; Narpala, Sandeep; Hatcher, Christian; Gillespie, Rebecca A; Creanga, Adrian; Kanekiyo, Masaru; Raab, Julie E; Andrews, Sarah F; Zhang, Yi; Yang, Eun Sung; Wang, Lingshu; Leung, Kwanyee; Kong, Wing-Pui; Freyn, Alec W; Nachbagauer, Raffael; Palese, Peter; Bailer, Robert T; McDermott, Adrian B; Koup, Richard A; Gall, Jason G; Arnold, Frank; Mascola, John R; Graham, Barney S; Ledgerwood, Julie E

A single-shot adenoviral vaccine provides hemagglutinin stalk-mediated protection against heterosubtypic influenza challenge in mice

单剂腺病毒疫苗可为小鼠提供血凝素柄介导的针对异亚型流感病毒攻击的保护

Carly M Bliss, Alec W Freyn, Tom G Caniels, Victor H Leyva-Grado, Raffael Nachbagauer, Weina Sun, Gene S Tan, Virginia L Gillespie, Meagan McMahon, Florian Krammer, Adrian V S Hill, Peter Palese, Lynda Coughlan

Altering the mRNA-1273 dosing interval impacts the kinetics, quality, and magnitude of immune responses in mice

改变 mRNA-1273 的给药间隔会影响小鼠免疫反应的动力学、质量和强度。

Dario Garcia-Dominguez ,Carole Henry ,LingZhi Ma ,Hardik Jani ,Nicholas J Amato ,Taylor Manning ,Alec Freyn ,Heather Davis ,Chiaowen Joyce Hsiao ,Mengying Li ,Hillary Koch ,Sayda Elbashir ,Anthony DiPiazza ,Andrea Carfi ,Darin Edwards ,Kapil Bahl

First exposure to the pandemic H1N1 virus induced broadly neutralizing antibodies targeting hemagglutinin head epitopes

首次接触大流行性 H1N1 病毒会诱发针对血凝素头部表位的广泛中和抗体

Jenna J Guthmiller, Julianna Han, Lei Li, Alec W Freyn, Sean T H Liu, Olivia Stovicek, Christopher T Stamper, Haley L Dugan, Micah E Tepora, Henry A Utset, Dalia J Bitar, Natalie J Hamel, Siriruk Changrob, Nai-Ying Zheng, Min Huang, Florian Krammer, Raffael Nachbagauer, Peter Palese, Andrew B Ward, 

CD4+ follicular regulatory T cells optimize the influenza virus-specific B cell response

CD4+ 滤泡调节性 T 细胞优化流感病毒特异性 B 细胞反应

Yisi Lu, Roy Jiang, Alec W Freyn, Jiawei Wang, Shirin Strohmeier, Katlyn Lederer, Michela Locci, Hongyu Zhao, Davide Angeletti, Kevin C O'Connor, Steven H Kleinstein, Raffael Nachbagauer, Joe Craft

Influenza hemagglutinin-specific IgA Fc-effector functionality is restricted to stalk epitopes

流感血凝素特异性 IgA Fc 效应子功能仅限于茎表位

Alec W Freyn, Julianna Han, Jenna J Guthmiller, Mark J Bailey, Karlynn Neu, Hannah L Turner, Victoria C Rosado, Veronika Chromikova, Min Huang, Shirin Strohmeier, Sean T H Liu, Viviana Simon, Florian Krammer, Andrew B Ward, Peter Palese, Patrick C Wilson, Raffael Nachbagauer

Antigen modifications improve nucleoside-modified mRNA-based influenza virus vaccines in mice

抗原修饰可改善小鼠中核苷修饰的 mRNA 流感病毒疫苗

Alec W Freyn, Matthew Pine, Victoria C Rosado, Marcel Benz, Hiromi Muramatsu, Mitchell Beattie, Ying K Tam, Florian Krammer, Peter Palese, Raffael Nachbagauer, Meagan McMahon, Norbert Pardi

A Multi-Targeting, Nucleoside-Modified mRNA Influenza Virus Vaccine Provides Broad Protection in Mice

多靶点核苷修饰的 mRNA 流感病毒疫苗可为小鼠提供广泛保护

Alec W Freyn, Jamile Ramos da Silva, Victoria C Rosado, Carly M Bliss, Matthew Pine, Barbara L Mui, Ying K Tam, Thomas D Madden, Luís Carlos de Souza Ferreira, Drew Weissman, Florian Krammer, Lynda Coughlan, Peter Palese, Norbert Pardi, Raffael Nachbagauer