日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification of targetable vulnerabilities of PLK1-overexpressing cancers by synthetic dosage lethality.

通过合成剂量致死性鉴定 PLK1 过表达癌症的可靶向脆弱性

Cunningham Chelsea E, Vizeacoumar Frederick S, Zhang Yue, Kyrylenko Liliia, Both Simon, Maranda Vincent, Dong He, Price Jared D W, Gao Peng, Wagner Konrad, Wu Yingwen, Lazell-Wright Mary, Ganapathysamy Ashtalakshmi, Hari Rithik, Bhanumathy Kalpana K, Denomy Connor, Saxena Anjali, Vizeacoumar Jeff P, Morales Alain Morejon, Khan Faizaan, Mosley Shayla, Chen Angie, Katrii Tetiana, Zoller Ben G E, Rajamanickam Karthic, Walke Prachi, Gong Lihui, Patel Hardikkumar, Elhasasna Hussain, Dahiya Renuka, Abuhussein Omar, Dmitriev Anton, Freywald Tanya, Munhoz Erika Prando, Ruppin Eytan, Lee Joo Sang, Rox Katharina, Koebel Martin, Hopkins Laura, Lee Cheng Han, Yadav Sunil, Gasparoni Gilles, Walter Jörn, Krishnan Anand, Datla Raju, Toosi Behzad, Baker Kristi, Meens Jalna, Cescon David W, Ailles Laurie, Leary Scot C, Wu Yuliang, Empting Martin, Kiemer Alexandra K, Freywald Andrew, Vizeacoumar Franco J

A novel role for Neurog2 in MYCN driven neuroendocrine plasticity of prostate cancer

Neurog2在MYCN驱动的前列腺癌神经内分泌可塑性中的新作用

Walke, Prachi; Price, Jared D W; Vizeacoumar, Frederick S; Joseph, Nickson; Maranda, Vincent; Chowdhury, Bari; Patel, Jay; Zhang, Yue; Dong, He; New, Lara; Ganapathysamy, Ashtalakshmi; Gong, Li Hui; Lazell-Wright, Mary; Elhasasna, Hussain; Bhanumathy, Kalpana K; Wu, Yuliang; Wang, Yuzhuo; Freywald, Andrew; Krishnan, Anand; Vizeacoumar, Franco J

EGFR Phosphorylates and Associates with EFNB1 to Regulate Cell Adhesion to Fibronectin.

EGFR 磷酸化并与 EFNB1 结合,从而调节细胞与纤连蛋白的粘附

Osornio-Hernández Ana I, Chartier François J M, Schuehle Tim L, Banerjee Sara L, Elowe Sabine, Laprise Patrick, Freywald Andrew, Laurin Mélanie, Bisson Nicolas

Systematic Comparison of CRISPR and shRNA Screens to Identify Essential Genes Using a Graph-Based Unsupervised Learning Model

利用基于图的无监督学习模型系统地比较 CRISPR 和 shRNA 筛选方法以识别必需基因

Ding, Yulian; Denomy, Connor; Freywald, Andrew; Pan, Yi; Vizeacoumar, Franco J; Vizeacoumar, Frederick S; Wu, Fang-Xiang

Cancer Cell's Achilles Heels: Considerations for Design of Anti-Cancer Drug Combinations

癌细胞的阿喀琉斯之踵:抗癌药物组合设计中的考量因素

Gahramanov, Valid; Vizeacoumar, Frederick S; Morales, Alain Morejon; Bonham, Keith; Sakharkar, Meena K; Kumar, Santosh; Vizeacoumar, Franco J; Freywald, Andrew; Sherman, Michael Y

Breast Tumor Metastasis and Its Microenvironment: It Takes Both Seed and Soil to Grow a Tumor and Target It for Treatment

乳腺肿瘤转移及其微环境:肿瘤的生长和治疗靶向都需要种子和土壤

Bonni, Shirin; Brindley, David N; Chamberlain, M Dean; Daneshvar-Baghbadorani, Nima; Freywald, Andrew; Hemmings, Denise G; Hombach-Klonisch, Sabine; Klonisch, Thomas; Raouf, Afshin; Shemanko, Carrie Simone; Topolnitska, Diana; Visser, Kaitlyn; Vizeacoumar, Franco J; Wang, Edwin; Gibson, Spencer B

Protein Tyrosine Kinases: Their Roles and Their Targeting in Leukemia

蛋白酪氨酸激酶:它们在白血病中的作用及其靶向治疗

K Bhanumathy, Kalpana; Balagopal, Amrutha; Vizeacoumar, Frederick S; Vizeacoumar, Franco J; Freywald, Andrew; Giambra, Vincenzo

Mining the plasma-proteome associated genes in patients with gastro-esophageal cancers for biomarker discovery

挖掘胃食管癌患者血浆蛋白质组相关基因以发现生物标志物

Vizeacoumar, Frederick S; Guo, Hongyu; Dwernychuk, Lynn; Zaidi, Adnan; Freywald, Andrew; Wu, Fang-Xiang; Vizeacoumar, Franco J; Ahmed, Shahid

TLR9 agonist enhances radiofrequency ablation-induced CTL responses, leading to the potent inhibition of primary tumor growth and lung metastasis

TLR9激动剂可增强射频消融诱导的CTL反应,从而有效抑制原发肿瘤生长和肺转移。

Xu, Aizhang; Zhang, Lifeng; Yuan, Jingying; Babikr, Fatma; Freywald, Andrew; Chibbar, Rajni; Moser, Michael; Zhang, Wenjun; Zhang, Bing; Fu, Zhaoying; Xiang, Jim

Transgenic 4-1BBL-engineered vaccine stimulates potent Gag-specific therapeutic and long-term immunity via increased priming of CD44(+)CD62L(high) IL-7R(+) CTLs with up- and downregulation of anti- and pro-apoptosis genes

转基因4-1BBL工程疫苗通过增强CD44(+)CD62L(high)IL-7R(+) CTL的启动,并上调和下调抗凋亡基因和促凋亡基因,从而刺激产生强效的Gag特异性治疗性和长期免疫力。

Wang, Rong; Freywald, Andrew; Chen, Yue; Xu, Jianqing; Tan, Xin; Xiang, Jim