日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Dual inhibition of α(v)β(6) and α(v)β(1) reduces fibrogenesis in lung tissue explants from patients with IPF

双重抑制α(v)β(6)和α(v)β(1)可减少特发性肺纤维化患者肺组织外植体中的纤维化。

Decaris, Martin L; Schaub, Johanna R; Chen, Chun; Cha, Jacob; Lee, Gail G; Rexhepaj, Megi; Ho, Steve S; Rao, Vikram; Marlow, Megan M; Kotak, Prerna; Budi, Erine H; Hooi, Lisa; Wu, Jianfeng; Fridlib, Marina; Martin, Shamra P; Huang, Shaoyi; Chen, Ming; Muñoz, Manuel; Hom, Timothy F; Wolters, Paul J; Desai, Tushar J; Rock, Fernando; Leftheris, Katerina; Morgans, David J; Lepist, Eve-Irene; Andre, Patrick; Lefebvre, Eric A; Turner, Scott M

FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models through Disruption of Tubulin Palmitoylation and Microtubule Organization and FASN Inhibition-Mediated Effects on Oncogenic Signaling and Gene Expression

FASN 抑制和紫杉烷治疗相结合,通过破坏微管蛋白棕榈酰化和微管组织以及 FASN 抑制介导的对致癌信号和基因表达的影响,增强了多种异种移植肿瘤模型中的抗肿瘤功效

Timothy S Heuer, Richard Ventura, Kasia Mordec, Julie Lai, Marina Fridlib, Douglas Buckley, George Kemble

Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression

脂肪酸合酶抑制棕榈酸从头合成可通过重塑细胞膜、抑制信号通路和重编程基因表达来诱导肿瘤细胞凋亡

Richard Ventura, Kasia Mordec, Joanna Waszczuk, Zhaoti Wang, Julie Lai, Marina Fridlib, Douglas Buckley, George Kemble, Timothy S Heuer

Blocking macrophage leukotriene b4 prevents endothelial injury and reverses pulmonary hypertension

阻断巨噬细胞白三烯 b4 可防止内皮损伤并逆转肺动脉高压

Wen Tian, Xinguo Jiang, Rasa Tamosiuniene, Yon K Sung, Jin Qian, Gundeep Dhillon, Lajos Gera, Laszlo Farkas, Marlene Rabinovitch, Roham T Zamanian, Mohammed Inayathullah, Marina Fridlib, Jayakumar Rajadas, Marc Peters-Golden, Norbert F Voelkel, Mark R Nicolls