The Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease Trial: A study of crenezumab versus placebo in preclinical PSEN1 E280A mutation carriers to evaluate efficacy and safety in the treatment of autosomal-dominant Alzheimer's disease, including a placebo-treated noncarrier cohort
阿尔茨海默病预防计划常染色体显性遗传阿尔茨海默病试验:一项针对临床前PSEN1 E280A突变携带者,比较crenezumab与安慰剂治疗常染色体显性遗传阿尔茨海默病疗效和安全性的研究,其中包括一个接受安慰剂治疗的非携带者队列。
期刊:Alzheimer's and Dementia: Translational Research and Clinical Interventions
影响因子:6.8
doi:10.1016/j.trci.2018.02.002
Tariot, Pierre N; Lopera, Francisco; Langbaum, Jessica B; Thomas, Ronald G; Hendrix, Suzanne; Schneider, Lon S; Rios-Romenets, Silvia; Giraldo, Margarita; Acosta, Natalia; Tobon, Carlos; Ramos, Claudia; Espinosa, Alejandro; Cho, William; Ward, Michael; Clayton, David; Friesenhahn, Michael; Mackey, Howard; Honigberg, Lee; Sanabria Bohorquez, Sandra; Chen, Kewei; Walsh, Trisha; Langlois, Carolyn; Reiman, Eric M