日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A self-complementary recombinant adeno-associated virus vector coding for an anchorless prion protein carrying the G127V mutation extends survival in a rodent prion disease model

一种编码携带 G127V 突变的无锚定朊病毒蛋白的自互补重组腺相关病毒载体,可延长啮齿动物朊病毒病模型中的存活时间。

Zerbes, Thomas; Verkuyl, Claire; Zhang, Cunjie; Grunnesjoe, Sophie; Eid, Shehab; Arshad, Hamza; Zhao, Wenda; Nasser, Zahra; O'Shea, Teaghan; Belotserkovsky, Ari; Lamoureux, Lise; Frost, Kathy L; Myskiw, Jennifer; Li, Leyao; Stuart, Erica; Wille, Holger; Booth, Stephanie; Watts, Joel C; Schmitt-Ulms, Gerold

Prion replication in organotypic brain slice cultures is distinct from in vivo inoculation and is species dependent.

朊病毒在器官型脑片培养物中的复制与体内接种不同,并且具有物种依赖性

Slota Jessy A, Lamoureux Lise, Myskiw Jennifer, Frost Kathy L, Medina Sarah J, Kielich Dominic M S, Leonhardt Melanie, Thapar Gunjan, Bailey-Elkin Ben A, Booth Stephanie A

Single-cell transcriptomics unveils molecular signatures of neuronal vulnerability in a mouse model of prion disease that overlap with Alzheimer's disease

单细胞转录组学揭示了朊病毒病小鼠模型中神经元脆弱性的分子特征,这些特征与阿尔茨海默病重叠

Slota, Jessy A; Lamoureux, Lise; Frost, Kathy L; Sajesh, Babu V; Booth, Stephanie A

Non-Productive Infection of Glial Cells with SARS-CoV-2 in Hamster Organotypic Cerebellar Slice Cultures

SARS-CoV-2 在仓鼠小脑组织切片培养中对神经胶质细胞的非生产性感染

Lamoureux, Lise; Sajesh, Babu; Slota, Jessy A; Medina, Sarah J; Mayor, Matthew; Frost, Kathy L; Warner, Bryce; Manguiat, Kathy; Wood, Heidi; Kobasa, Darwyn; Booth, Stephanie A

Neurons and Astrocytes Elicit Brain Region Specific Transcriptional Responses to Prion Disease in the Murine CA1 and Thalamus

神经元和星形胶质细胞在小鼠CA1区和丘脑中对朊病毒疾病产生脑区特异性转录反应

Slota, Jessy A; Medina, Sarah J; Frost, Kathy L; Booth, Stephanie A

The cell type resolved mouse transcriptome in neuron-enriched brain tissues from the hippocampus and cerebellum during prion disease

在朊病毒病期间,从海马和小脑中富含神经元的脑组织中分离出小鼠的细胞类型转录组

Majer, Anna; Medina, Sarah J; Sorensen, Debra; Martin, Matthew J; Frost, Kathy L; Phillipson, Clark; Manguiat, Kathy; Booth, Stephanie A

Vesicular Stomatitis Virus-Based Vaccines Provide Cross-Protection against Andes and Sin Nombre Viruses

基于水疱性口炎病毒的疫苗可提供针对安第斯病毒和辛诺布雷病毒的交叉保护

Warner, Bryce M; Stein, Derek R; Jangra, Rohit K; Slough, Megan M; Sroga, Patrycja; Sloan, Angela; Frost, Kathy L; Booth, Stephanie; Chandran, Kartik; Safronetz, David

A Novel Triple-Mutant AAV6 Capsid Induces Rapid and Potent Transgene Expression in the Muscle and Respiratory Tract of Mice

新型三突变体AAV6衣壳可在小鼠肌肉和呼吸道中诱导快速高效的转基因表达

van Lieshout, Laura P; Domm, Jakob M; Rindler, Tara N; Frost, Kathy L; Sorensen, Debra L; Medina, Sarah J; Booth, Stephanie A; Bridges, James P; Wootton, Sarah K

Intramuscular Adeno-Associated Virus-Mediated Expression of Monoclonal Antibodies Provides 100% Protection Against Ebola Virus Infection in Mice

肌内注射腺相关病毒介导的单克隆抗体表达可为小鼠提供100%的埃博拉病毒感染保护

van Lieshout, Laura P; Soule, Geoff; Sorensen, Debra; Frost, Kathy L; He, Shihua; Tierney, Kevin; Safronetz, David; Booth, Stephanie A; Kobinger, Gary P; Qiu, Xiangguo; Wootton, Sarah K