日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An integrated transcriptomic cell atlas of human endoderm-derived organoids

人类内胚层衍生类器官的整合转录组细胞图谱

Xu, Quan; Halle, Lennard; Hediyeh-Zadeh, Soroor; Kuijs, Merel; Riedweg, Rya; Kilik, Umut; Recaldin, Timothy; Yu, Qianhui; Rall, Isabell; Frum, Tristan; Adam, Lukas; Parikh, Shrey; Kfuri-Rubens, Raphael; Gander, Manuel; Klein, Dominik; Curion, Fabiola; He, Zhisong; Fleck, Jonas Simon; Oost, Koen; Kahnwald, Maurice; Barbiero, Silvia; Mitrofanova, Olga; Maciag, Grzegorz Jerzy; Jensen, Kim B; Lutolf, Matthias; Liberali, Prisca; Spence, Jason R; Gjorevski, Nikolche; Beumer, Joep; Treutlein, Barbara; Theis, Fabian J; Camp, J Gray

Nascent matrix deposition supports alveolar organoid formation from aggregates in synthetic hydrogels

新生基质沉积支持合成水凝胶中聚集体形成肺泡类器官

Eiken, Madeline K; Childs, Charlie J; Brastrom, Lindy K; Frum, Tristan; Plaster, Eleanor M; Ahmed, Donia W; Spencer, Ryan C; Shachaf, Orren; Pfeiffer, Suzanne; Levine, Justin E; Alysandratos, Konstantinos-Dionysios; Kotton, Darrell N; Spence, Jason R; Loebel, Claudia

Clinical Interventions and Inflammatory Signaling Shape the Transcriptional and Cellular Architecture of the Early Postnatal Lung

临床干预和炎症信号通路塑造了早期出生后肺的转录和细胞结构

Frum, Tristan; Wu, Angeline; Ymayo, Marcela S; Tsai, Yu-Hwai; Huang, Sha; Yang, Mengkun; Clark, Sydney G; Hsu, Peggy P; Glass, Ian A; Deutsch, Gail H; Spence, Jason R

A scalable long-term in vitro model of human colonic epithelium with continuous barrier function

具有持续屏障功能的、可扩展的人类结肠上皮长期体外模型

Cuttitta, Ashley J; Meyer, Sophia R; Frum, Tristan; Gunuguntla, Bhargavasai; Wu, Angeline; Huang, Sha; Morgan, Jack; Dame, Michael K; Sexton, Jonathan Z; Spence, Jason R

Differential Bioactivation Profiles of Different GS-441524 Prodrugs in Cell and Mouse Models: ProTide Prodrugs with High Cell Permeability and Susceptibility to Cathepsin A Are More Efficient in Delivering Antiviral Active Metabolites to the Lung.

GS-441524 前药在细胞和小鼠模型中的差异生物活化特征:具有高细胞渗透性和对组织蛋白酶 A 敏感性的 ProTide 前药能更有效地将抗病毒活性代谢物输送到肺部

Li Jiapeng, de Melo Jorge Daniel Macedo, Wang Weiwen, Sun Shuxin, Frum Tristan, Hang Yu-An, Liu Yueting, Zhou Xingwu, Xiao Jingcheng, Wang Xinwen, Spence Jason R, Wobus Christiane E, Zhu Hao-Jie

Correction to: hPSC-derived organoids: models of human development and disease

更正:hPSC衍生类器官:人类发育和疾病模型

Frum, Tristan; Spence, Jason R

Culture conditions antagonize lineage-promoting signaling in the mouse blastocyst.

培养条件会抑制小鼠囊胚中促进谱系分化的信号传导

Frum Tristan, Ralston Amy

Understanding Human Lung Development through In Vitro Model Systems

利用体外模型系统了解人类肺发育

Conway, Renee F; Frum, Tristan; Conchola, Ansley S; Spence, Jason R

Cell signaling and transcription factors regulating cell fate during formation of the mouse blastocyst

小鼠囊胚形成过程中调控细胞命运的细胞信号传导和转录因子

Frum, Tristan; Ralston, Amy

Oct4 cell-autonomously promotes primitive endoderm development in the mouse blastocyst

Oct4 以细胞自主的方式促进小鼠囊胚中原始内胚层的发育

Frum, Tristan; Halbisen, Michael A; Wang, Chaoyang; Amiri, Hossein; Robson, Paul; Ralston, Amy