日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Chemoresistance of TP53 mutant acute myeloid leukemia requires the mevalonate byproduct, geranylgeranyl pyrophosphate, for induction of an adaptive stress response

TP53突变型急性髓系白血病的化疗耐药性需要甲羟戊酸的副产物——香叶基香叶基焦磷酸——来诱导适应性应激反应。

Skuli, Sarah J; Bakayoko, A'ishah; Kruidenier, Marisa; Manning, Bryan; Pammer, Paige; Salimov, Akmal; Riley, Owen; Brake-Sillá, Gisela; Dopkin, Derrick; Bowman, Michael; Martinez-Gutierrez, Leslie N; Anderson, Colin C; Reisz, Julie A; Buono, Roberta; Paul, Madhuri; Saland, Estelle; Liccardo, Francesca; DeVine, Ann; Wong, Sarah; Xu, Jimmy P; Nee, Eva; Hausler, Ryan; Boettcher, Steffen; Sebti, Said M; Lai, Catherine; Maxwell, Kara N; Sarry, Jean-Emmanuel; Fruman, David A; D'Alessandro, Angelo; Mesaros, Clementina; Keith, Brian; Simon, M Celeste; Sung, Pamela J; Wertheim, Gerald; Skuli, Nicolas; Bowman, Robert L; Matthews, Andrew; Carroll, Martin

Sphingosine simultaneously inhibits nuclear import and activates PP2A by binding importins and PPP2R1A

鞘氨醇通过与输入蛋白和PPP2R1A结合,同时抑制核输入并激活PP2A。

Vaishali Jayashankar # ,Peter Kubiniok # ,Alison N McCracken # ,Rebeca G Gentry ,Kazumi H Eckenstein ,Lorenzo Sernissi ,Vito Vece ,Jean-Baptiste Garsi ,Sarah Y Valles ,Sunhee Jung ,Natalie C Hoffman ,Arielle S Perrochon ,Elizabeth M Selwan ,Brendan T Finicle ,Mary Pitman ,DaWei Lin ,Éric Bonneil ,Ruijuan Xu ,Cungui Mao ,Peter Kaiser ,David A Fruman ,David Mobley ,Cholsoon Jang ,Stephen Hanessian ,Pierre Thibault ,Aimee L Edinger

Pitavastatin counteracts venetoclax resistance mechanisms in acute myeloid leukemia by depleting geranylgeranyl pyrophosphate

匹伐他汀通过消耗牻牛儿基焦磷酸盐来对抗急性髓系白血病中的维奈托克耐药机制。

Buono, Roberta; Juarez, Dennis; Paul, Madhuri; Skuli, Sarah J; Wong, Ian B; Tarnekar, Ishita; Ying, Zhili; Le, Izabelle; Wertheim, Gerald; Bakayoko, A'ishah; Kruidenier, Marisa; Sebti, Said M; Konopleva, Marina; Fleischman, Angela G; Jang, Cholsoon; Carroll, Martin; Fruman, David A

Mevalonate Biosynthesis is a Metabolic Vulnerability of Gemcitabine-resistant Pancreatic Cancer

甲羟戊酸生物合成是吉西他滨耐药性胰腺癌的代谢脆弱性

Beutel, Alica K; Calderon, Sabrina; Nghiem, Ethan; Gulay, Kevin; Santana, Leonor P S; Zimmer, Eleni; Singh, Rima; Anaraki, Cecily; Yousefian, Natalie; Allgöwer, Chantal; Tong, Gregory; Geller, Cameron; Chao, Alina; Juarez, Dennis; Seufferlein, Thomas; Muir, Alexander; Jang, Cholsoon; Edinger, Aimee L; Seldin, Marcus; Martinez, Thomas F; Kleger, Alexander; Chang, David K; Tiriac, Herve; Valerin, Jennifer B; Fruman, David A; Halbrook, Christopher J

Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer

在三阴性乳腺癌中,他汀类药物靶向胆固醇生物合成与AKT抑制剂具有协同作用

Alissandra L Hillis ,Timothy D Martin ,Haley E Manchester ,Jenny Högström ,Na Zhang ,Emmalyn Lecky ,Nina Kozlova ,Jonah Lee ,Nicole S Persky ,David E Root ,Myles Brown ,Karen Cichowski ,Stephen J Elledge ,Taru Muranen ,David A Fruman ,Simon T Barry ,John G Clohessy ,Ralitsa R Madsen ,Alex Toker

PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer

PI3K/AKT/mTOR信号转导通路及其在癌症中的靶向治疗

Glaviano, Antonino; Foo, Aaron S C; Lam, Hiu Y; Yap, Kenneth C H; Jacot, William; Jones, Robert H; Eng, Huiyan; Nair, Madhumathy G; Makvandi, Pooyan; Geoerger, Birgit; Kulke, Matthew H; Baird, Richard D; Prabhu, Jyothi S; Carbone, Daniela; Pecoraro, Camilla; Teh, Daniel B L; Sethi, Gautam; Cavalieri, Vincenzo; Lin, Kevin H; Javidi-Sharifi, Nathalie R; Toska, Eneda; Davids, Matthew S; Brown, Jennifer R; Diana, Patrizia; Stebbing, Justin; Fruman, David A; Kumar, Alan P

Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics

同时抑制内吞循环和溶酶体融合使细胞和组织对寡核苷酸疗法敏感

Brendan T Finicle, Kazumi H Eckenstein, Alexey S Revenko, Brooke A Anderson, W Brad Wan, Alison N McCracken, Daniel Gil, David A Fruman, Stephen Hanessian, Punit P Seth, Aimee L Edinger

Nanocomplexes of doxorubicin and DNA fragments for efficient and safe cancer chemotherapy

用于高效安全癌症化疗的阿霉素与DNA片段纳米复合物

Mohammad, Saad N; Choi, Yeon Su; Chung, Jee Young; Cedrone, Edward; Neun, Barry W; Dobrovolskaia, Marina A; Yang, Xiaojing; Guo, Wei; Chew, Yap Ching; Kim, Juwan; Baek, Seunggul; Kim, Ik Soo; Fruman, David A; Kwon, Young Jik

Synthesis of a Complex Brasilicardin Analogue Utilizing a Cobalt-Catalyzed MHAT-Induced Radical Bicyclization Reaction

利用钴催化的MHAT诱导自由基双环化反应合成复杂的巴西卡汀类似物

Niman, Scott W; Buono, Roberta; Fruman, David A; Vanderwal, Christopher D

Novel pharmacological and dietary approaches to target mTOR in B-cell acute lymphoblastic leukemia

针对B细胞急性淋巴细胞白血病中mTOR的新型药理学和饮食疗法

Buono, Roberta; Alhaddad, Muneera; Fruman, David A