日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Chemoresistance of TP53 mutant acute myeloid leukemia requires the mevalonate byproduct, geranylgeranyl pyrophosphate, for induction of an adaptive stress response

TP53突变型急性髓系白血病的化疗耐药性需要甲羟戊酸的副产物——香叶基香叶基焦磷酸——来诱导适应性应激反应。

Skuli, Sarah J; Bakayoko, A'ishah; Kruidenier, Marisa; Manning, Bryan; Pammer, Paige; Salimov, Akmal; Riley, Owen; Brake-Sillá, Gisela; Dopkin, Derrick; Bowman, Michael; Martinez-Gutierrez, Leslie N; Anderson, Colin C; Reisz, Julie A; Buono, Roberta; Paul, Madhuri; Saland, Estelle; Liccardo, Francesca; DeVine, Ann; Wong, Sarah; Xu, Jimmy P; Nee, Eva; Hausler, Ryan; Boettcher, Steffen; Sebti, Said M; Lai, Catherine; Maxwell, Kara N; Sarry, Jean-Emmanuel; Fruman, David A; D'Alessandro, Angelo; Mesaros, Clementina; Keith, Brian; Simon, M Celeste; Sung, Pamela J; Wertheim, Gerald; Skuli, Nicolas; Bowman, Robert L; Matthews, Andrew; Carroll, Martin

Pitavastatin counteracts venetoclax resistance mechanisms in acute myeloid leukemia by depleting geranylgeranyl pyrophosphate

匹伐他汀通过消耗牻牛儿基焦磷酸盐来对抗急性髓系白血病中的维奈托克耐药机制。

Buono, Roberta; Juarez, Dennis; Paul, Madhuri; Skuli, Sarah J; Wong, Ian B; Tarnekar, Ishita; Ying, Zhili; Le, Izabelle; Wertheim, Gerald; Bakayoko, A'ishah; Kruidenier, Marisa; Sebti, Said M; Konopleva, Marina; Fleischman, Angela G; Jang, Cholsoon; Carroll, Martin; Fruman, David A

Mevalonate Biosynthesis is a Metabolic Vulnerability of Gemcitabine-resistant Pancreatic Cancer

甲羟戊酸生物合成是吉西他滨耐药性胰腺癌的代谢脆弱性

Beutel, Alica K; Calderon, Sabrina; Nghiem, Ethan; Gulay, Kevin; Santana, Leonor P S; Zimmer, Eleni; Singh, Rima; Anaraki, Cecily; Yousefian, Natalie; Allgöwer, Chantal; Tong, Gregory; Geller, Cameron; Chao, Alina; Juarez, Dennis; Seufferlein, Thomas; Muir, Alexander; Jang, Cholsoon; Edinger, Aimee L; Seldin, Marcus; Martinez, Thomas F; Kleger, Alexander; Chang, David K; Tiriac, Herve; Valerin, Jennifer B; Fruman, David A; Halbrook, Christopher J

A phase 1 study adding pitavastatin to venetoclax therapy in AML and CLL/SLL: a mechanism-based drug repurposing strategy

一项在急性髓系白血病 (AML) 和慢性淋巴细胞白血病/小淋巴细胞淋巴瘤 (CLL/SLL) 患者中,将匹伐他汀加入维奈克拉治疗方案的 1 期研究:一种基于机制的药物重定位策略

Brem, Elizabeth A; Shieh, Kevin; Juarez, Dennis; Buono, Roberta; Jeyakumar, Deepa; O'Brien, Susan; Taylor, Thomas H; Fruman, David A

PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer

PI3K/AKT/mTOR信号转导通路及其在癌症中的靶向治疗

Glaviano, Antonino; Foo, Aaron S C; Lam, Hiu Y; Yap, Kenneth C H; Jacot, William; Jones, Robert H; Eng, Huiyan; Nair, Madhumathy G; Makvandi, Pooyan; Geoerger, Birgit; Kulke, Matthew H; Baird, Richard D; Prabhu, Jyothi S; Carbone, Daniela; Pecoraro, Camilla; Teh, Daniel B L; Sethi, Gautam; Cavalieri, Vincenzo; Lin, Kevin H; Javidi-Sharifi, Nathalie R; Toska, Eneda; Davids, Matthew S; Brown, Jennifer R; Diana, Patrizia; Stebbing, Justin; Fruman, David A; Kumar, Alan P

Nanocomplexes of doxorubicin and DNA fragments for efficient and safe cancer chemotherapy

用于高效安全癌症化疗的阿霉素与DNA片段纳米复合物

Mohammad, Saad N; Choi, Yeon Su; Chung, Jee Young; Cedrone, Edward; Neun, Barry W; Dobrovolskaia, Marina A; Yang, Xiaojing; Guo, Wei; Chew, Yap Ching; Kim, Juwan; Baek, Seunggul; Kim, Ik Soo; Fruman, David A; Kwon, Young Jik

Synthesis of a Complex Brasilicardin Analogue Utilizing a Cobalt-Catalyzed MHAT-Induced Radical Bicyclization Reaction

利用钴催化的MHAT诱导自由基双环化反应合成复杂的巴西卡汀类似物

Niman, Scott W; Buono, Roberta; Fruman, David A; Vanderwal, Christopher D

Novel pharmacological and dietary approaches to target mTOR in B-cell acute lymphoblastic leukemia

针对B细胞急性淋巴细胞白血病中mTOR的新型药理学和饮食疗法

Buono, Roberta; Alhaddad, Muneera; Fruman, David A

Targeting the Mevalonate Pathway in Cancer

靶向甲羟戊酸途径治疗癌症

Juarez, Dennis; Fruman, David A

A cross-institutional analysis of the effects of broadening trainee professional development on research productivity

一项跨机构分析,旨在研究拓展受训人员专业发展对科研生产力的影响

Brandt, Patrick D; Sturzenegger Varvayanis, Susi; Baas, Tracey; Bolgioni, Amanda F; Alder, Janet; Petrie, Kimberly A; Dominguez, Isabel; Brown, Abigail M; Stayart, C Abigail; Singh, Harinder; Van Wart, Audra; Chow, Christine S; Mathur, Ambika; Schreiber, Barbara M; Fruman, David A; Bowden, Brent; Wiesen, Christopher A; Golightly, Yvonne M; Holmquist, Chris E; Arneman, Daniel; Hall, Joshua D; Hyman, Linda E; Gould, Kathleen L; Chalkley, Roger; Brennwald, Patrick J; Layton, Rebekah L