日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A randomized, cross-over trial of metoprolol succinate formulations to evaluate PK and PD end points for therapeutic equivalence

一项随机、交叉试验,旨在评估琥珀酸美托洛尔制剂的药代动力学和药效学终点,以确定其治疗等效性。

Mosley, Scott A; Kim, Sarah; El Rouby, Nihal; Lingineni, Karthik; Esteban, Valvanera Vozmediano; Gong, Yan; Chen, Yiqing; Estores, David; Feng, Kairui; Kim, Hyewon; Kinjo, Minori; Langaee, Taimour; Li, Zhichuan; Schmidt, Siegfried O F; Johnson, Julie A; Frye, Reginald F; Fang, Lanyan Lucy; Zhao, Liang; Binkley, Philip F; Schmidt, Stephan; Cavallari, Larisa H

Examination of Metoprolol Pharmacokinetics and Pharmacodynamics Across CYP2D6 Genotype-Derived Activity Scores

基于CYP2D6基因型衍生活性评分的美托洛尔药代动力学和药效学研究

Thomas, Cameron D; Mosley, Scott A; Kim, Sarah; Lingineni, Karthik; El Rouby, Nihal; Langaee, Taimour Y; Gong, Yan; Wang, Danxin; Schmidt, Siegfried O; Binkley, Philip F; Estores, David S; Feng, Kairui; Kim, Hyewon; Kinjo, Minori; Li, Zhichuan; Fang, Lanyan; Chapman, Arlene B; Cooper-DeHoff, Rhonda M; Gums, John G; Hamadeh, Issam S; Zhao, Liang; Schmidt, Stephan; Frye, Reginald F; Johnson, Julie A; Cavallari, Larisa H

A Genetic Score Associates With Pioglitazone Response in Patients With Non-alcoholic Steatohepatitis

基因评分与非酒精性脂肪性肝炎患者对吡格列酮的反应相关

Kawaguchi-Suzuki, Marina; Cusi, Kenneth; Bril, Fernando; Gong, Yan; Langaee, Taimour; Frye, Reginald F

Relative Bioavailability of Silybin A and Silybin B From 2 Multiconstituent Dietary Supplement Formulations Containing Milk Thistle Extract: A Single-dose Study

两种含水飞蓟提取物的多成分膳食补充剂配方中水飞蓟宾A和水飞蓟宾B的相对生物利用度:单剂量研究

Li, Wen-Yi; Yu, Guo; Hogan, Renee M; Mohandas, Rajesh; Frye, Reginald F; Gumpricht, Eric; Markowitz, John S

Pioglitazone improves hepatic mitochondrial function in a mouse model of nonalcoholic steatohepatitis.

在非酒精性脂肪性肝炎小鼠模型中,吡格列酮可改善肝脏线粒体功能

Kalavalapalli Srilaxmi, Bril Fernando, Koelmel Jeremy P, Abdo Kaitlyn, Guingab Joy, Andrews Paige, Li Wen-Yi, Jose Dhanya, Yost Richard A, Frye Reginald F, Garrett Timothy J, Cusi Kenneth, Sunny Nishanth E

Sphingolipid Metabolic Pathway Impacts Thiazide Diuretics Blood Pressure Response: Insights From Genomics, Metabolomics, and Lipidomics

鞘脂代谢途径影响噻嗪类利尿剂的血压反应:来自基因组学、代谢组学和脂质组学的见解

Shahin, Mohamed H; Gong, Yan; Frye, Reginald F; Rotroff, Daniel M; Beitelshees, Amber L; Baillie, Rebecca A; Chapman, Arlene B; Gums, John G; Turner, Stephen T; Boerwinkle, Eric; Motsinger-Reif, Alison; Fiehn, Oliver; Cooper-DeHoff, Rhonda M; Han, Xianlin; Kaddurah-Daouk, Rima; Johnson, Julie A

Pharmacogenomics competencies in pharmacy practice: A blueprint for change

药学实践中的药物基因组学能力:变革蓝图

Roederer, Mary W; Kuo, Grace M; Kisor, David F; Frye, Reginald F; Hoffman, James M; Jenkins, Jean; Weitzel, Kristin Wiisanen

A Genetic Response Score for Hydrochlorothiazide Use: Insights From Genomics and Metabolomics Integration

氢氯噻嗪使用的遗传反应评分:来自基因组学和代谢组学整合的见解

Shahin, Mohamed H; Gong, Yan; McDonough, Caitrin W; Rotroff, Daniel M; Beitelshees, Amber L; Garrett, Timothy J; Gums, John G; Motsinger-Reif, Alison; Chapman, Arlene B; Turner, Stephen T; Boerwinkle, Eric; Frye, Reginald F; Fiehn, Oliver; Cooper-DeHoff, Rhonda M; Kaddurah-Daouk, Rima; Johnson, Julie A

Novel plasma biomarker of atenolol-induced hyperglycemia identified through a metabolomics-genomics integrative approach

通过代谢组学-基因组学整合方法鉴定出阿替洛尔诱导高血糖的新型血浆生物标志物

de Oliveira, Felipe A; Shahin, Mohamed H; Gong, Yan; McDonough, Caitrin W; Beitelshees, Amber L; Gums, John G; Chapman, Arlene B; Boerwinkle, Eric; Turner, Stephen T; Frye, Reginald F; Fiehn, Oliver; Kaddurah-Daouk, Rima; Johnson, Julie A; Cooper-DeHoff, Rhonda M

Presence of arachidonoyl-carnitine is associated with adverse cardiometabolic responses in hypertensive patients treated with atenolol.

花生四烯酸肉碱的存在与接受阿替洛尔治疗的高血压患者的不良心血管代谢反应有关

Weng Liming, Gong Yan, Culver Jeffrey, Gardell Stephen J, Petucci Christopher, Morse Alison M, Frye Reginald F, Turner Stephen T, Chapman Arlene, Boerwinkle Eric, Gums John, Beitelshees Amber L, Borum Peggy R, Johnson Julie A, Garrett Timothy J, McIntyre Lauren M, Cooper-DeHoff Rhonda M