日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of Small-Molecule Antagonists of PHF1 and 19 Demonstrates the Ligandability of PRC2 Accessory Proteins

PHF1和PHF19小分子拮抗剂的发现证明了PRC2辅助蛋白的配体结合能力

Amick, Isabelle E; Johnson, Rebecca L; Liu, Jiuyang; Bussey-Sutton, Cameron R; Mancera-Ortiz, Ikeer Y; Norris-Drouin, Jacqueline L; Boyd, Shelton R; Cholensky, Stephanie H; Spangler, Cathy J; McGinty, Robert K; Strahl, Brian D; Kutateladze, Tatiana G; Frye, Stephen V; James, Lindsey I

Application of a MALDI mass spectrometry assay to identify covalent fragments targeting the methyl-lysine reader protein MPP8

应用MALDI质谱分析法鉴定靶向甲基赖氨酸识别蛋白MPP8的共价片段

Rubiano, Juanita L Sanchez; Buttery, Peter H; Gurard-Levin, Zachary A; Norris-Drouin, Jacqueline L; Mather, Lilyan M; Hardy, P Brian; Frye, Stephen V; James, Lindsey I

Discovery of Novel Macrocyclic MERTK/AXL Dual Inhibitors.

新型大环MERTK/AXL双重抑制剂的发现

Kong Deyu, Tian Qiang, Chen Zhilong, Zheng Hongchao, Stashko Michael A, Yan Dan, Earp H Shelton, Frye Stephen V, DeRyckere Deborah, Kireev Dmitri, Graham Douglas K, Wang Xiaodong

Discovery of CHD1 Antagonists for PTEN-Deficient Prostate Cancer.

发现用于治疗 PTEN 缺陷型前列腺癌的 CHD1 拮抗剂

Johnson Rebecca L, Graboski Amanda L, Li Fengling, Norris-Drouin Jacqueline L, Walton William G, Arrowsmith Cheryl H, Redinbo Matthew R, Frye Stephen V, James Lindsey I

An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering

小分子拮抗剂和蛋白质工程揭示了53BP1的自身抑制状态

Cui, Gaofeng; Botuyan, Maria Victoria; Drané, Pascal; Hu, Qi; Bragantini, Benoît; Thompson, James R; Schuller, David J; Detappe, Alexandre; Perfetti, Michael T; James, Lindsey I; Frye, Stephen V; Chowdhury, Dipanjan; Mer, Georges

Fused Tetrahydroquinolines Are Interfering with Your Assay

稠合四氢喹啉会干扰您的检测

Bashore, Frances M; Annor-Gyamfi, Joel; Du, Yuhong; Katis, Vittorio; Nwogbo, Felix; Flax, Raymond G; Frye, Stephen V; Pearce, Kenneth H; Fu, Haian; Willson, Timothy M; Drewry, David H; Axtman, Alison D

AD Informer Set: Chemical tools to facilitate Alzheimer's disease drug discovery

AD信息库:用于促进阿尔茨海默病药物研发的化学工具

Potjewyd, Frances M; Annor-Gyamfi, Joel K; Aubé, Jeffrey; Chu, Shaoyou; Conlon, Ivie L; Frankowski, Kevin J; Guduru, Shiva K R; Hardy, Brian P; Hopkins, Megan D; Kinoshita, Chizuru; Kireev, Dmitri B; Mason, Emily R; Moerk, Charles T; Nwogbo, Felix; Pearce, Kenneth H; Richardson, Timothy I; Rogers, David A; Soni, Disha M; Stashko, Michael; Wang, Xiaodong; Wells, Carrow; Willson, Timothy M; Frye, Stephen V; Young, Jessica E; Axtman, Alison D

Use of AD Informer Set compounds to explore validity of novel targets in Alzheimer's disease pathology

利用AD Informer Set化合物探索阿尔茨海默病病理学中新靶点的有效性

Potjewyd, Frances M; Annor-Gyamfi, Joel K; Aubé, Jeffrey; Chu, Shaoyou; Conlon, Ivie L; Frankowski, Kevin J; Guduru, Shiva K R; Hardy, Brian P; Hopkins, Megan D; Kinoshita, Chizuru; Kireev, Dmitri B; Mason, Emily R; Moerk, Charles T; Nwogbo, Felix; Pearce, Kenneth H Jr; Richardson, Timothy I; Rogers, David A; Soni, Disha M; Stashko, Michael; Wang, Xiaodong; Wells, Carrow; Willson, Timothy M; Frye, Stephen V; Young, Jessica E; Axtman, Alison D

Target 2035 - update on the quest for a probe for every protein

2035年目标——为每种蛋白质寻找探针的最新进展

Müller, Susanne; Ackloo, Suzanne; Al Chawaf, Arij; Al-Lazikani, Bissan; Antolin, Albert; Baell, Jonathan B; Beck, Hartmut; Beedie, Shaunna; Betz, Ulrich A K; Bezerra, Gustavo Arruda; Brennan, Paul E; Brown, David; Brown, Peter J; Bullock, Alex N; Carter, Adrian J; Chaikuad, Apirat; Chaineau, Mathilde; Ciulli, Alessio; Collins, Ian; Dreher, Jan; Drewry, David; Edfeldt, Kristina; Edwards, Aled M; Egner, Ursula; Frye, Stephen V; Fuchs, Stephen M; Hall, Matthew D; Hartung, Ingo V; Hillisch, Alexander; Hitchcock, Stephen H; Homan, Evert; Kannan, Natarajan; Kiefer, James R; Knapp, Stefan; Kostic, Milka; Kubicek, Stefan; Leach, Andrew R; Lindemann, Sven; Marsden, Brian D; Matsui, Hisanori; Meier, Jordan L; Merk, Daniel; Michel, Maurice; Morgan, Maxwell R; Mueller-Fahrnow, Anke; Owen, Dafydd R; Perry, Benjamin G; Rosenberg, Saul H; Saikatendu, Kumar Singh; Schapira, Matthieu; Scholten, Cora; Sharma, Sujata; Simeonov, Anton; Sundström, Michael; Superti-Furga, Giulio; Todd, Matthew H; Tredup, Claudia; Vedadi, Masoud; von Delft, Frank; Willson, Timothy M; Winter, Georg E; Workman, Paul; Arrowsmith, Cheryl H

Assessing the Cell Permeability of Bivalent Chemical Degraders Using the Chloroalkane Penetration Assay

利用氯代烷渗透试验评估二价化学降解剂的细胞渗透性

Foley, Caroline A; Potjewyd, Frances; Lamb, Kelsey N; James, Lindsey I; Frye, Stephen V