日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Understanding the Role of H-Bonds in the Stability of Molecular Glue-Induced Ternary Complexes

了解氢键在分子胶诱导的三元复合物稳定性中的作用

Blanco-Gabella, Patricia; Ivanova, Varbina; Serrano-Morrás, Álvaro; Fuchs, Julian E; Juárez-Jiménez, Jordi

Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control.

微生物三甲胺对 IRAK4 的抑制作用可减轻代谢炎症并改善血糖控制。

Chilloux Julien, Brial Francois, Everard Amandine, Smyth David, Andrikopoulos Petros, Zhang Liyong, Plovier Hubert, Myridakis Antonis, Hoyles Lesley, Moreno-Navarrete José Maria, Luque Jèssica Latorre, Casagrande Viviana, Menghini Rossella, Ahmetaj-Shala Blerina, Blancher Christine, Martinez-Gili Laura, Gencer Selin, Fearnside Jane F, Barton Richard H, Neves Ana Luisa, Rothwell Alice R, Gérard Christelle, Calderari Sophie, Williamson Mark J, Fuchs Julian E, Govada Lata, Boulangé Claire L, Patel Saroor, Scott James, Thursz Mark, Chayen Naomi, Glen Robert C, Gooderham Nigel J, Nicholson Jeremy K, Federici Massimo, Fernández-Real José Manuel, Gauguier Dominique, Liu Peter P, Cani Patrice D, Dumas Marc-Emmanuel

Drugit: crowd-sourcing molecular design of non-peptidic VHL binders

Drugit:众包非肽类VHL结合剂的分子设计

Scott, Thomas; Smethurst, Christian Alan Paul; Westermaier, Yvonne; Mayer, Moriz; Greb, Peter; Kousek, Roland; Biberger, Tobias; Bader, Gerd; Jandova, Zuzana; Schmalhorst, Philipp S; Fuchs, Julian E; Magarkar, Aniket; Hoenke, Christoph; Gerstberger, Thomas; Combs, Steven A; Pape, Richard; Phul, Saksham; Kothiwale, Sandeepkumar; Bergner, Andreas; Waterson, Alex G; Weinstabl, Harald; McConnell, Darryl B; Meiler, Jens; Böttcher, Jark; Moretti, Rocco

Discovery of BI-2493, a Pan-KRAS Inhibitor Showing In Vivo Efficacy.

发现 BI-2493,一种泛 KRAS 抑制剂,显示出体内疗效

Bröker Joachim, Waterson Alex G, Hodges Timothy R, Abbott Jason R, Arnold Allison, Böttcher Jark, Braun Nina, Cui Jianwen, Fuchs Julian E, Gerstberger Thomas, Gogg Sebastian, Hanner Sabine, Herdeis Lorenz, Howell Lucas W, Mantoulidis Andreas, Mayer Moriz, Phan Jason, Rocchetti Francesca, Sankar Kyra, Sarkar Dhruba, Schaaf Otmar, Sensintaffar John L, Sun Qi, Wunberg Tobias, Fesik Stephen W

Getting a Grip on the Undrugged: Targeting β-Catenin with Fragment-Based Methods

有效控制未受药物影响的疾病:利用基于片段的方法靶向β-catenin

Kessler, Dirk; Mayer, Moriz; Zahn, Stephan K; Zeeb, Markus; Wöhrle, Simon; Bergner, Andreas; Bruchhaus, Jens; Ciftci, Tuncay; Dahmann, Georg; Dettling, Maike; Döbel, Sandra; Fuchs, Julian E; Geist, Leonhard; Hela, Wolfgang; Kofink, Christiane; Kousek, Roland; Moser, Franziska; Puchner, Teresa; Rumpel, Klaus; Scharnweber, Maximilian; Werni, Patrick; Wolkerstorfer, Bernhard; Breitsprecher, Dennis; Baaske, Philipp; Pearson, Mark; McConnell, Darryl B; Böttcher, Jark

PI by NMR: Probing CH-π Interactions in Protein-Ligand Complexes by NMR Spectroscopy

利用核磁共振波谱法探测蛋白质-配体复合物中的CH-π相互作用

Platzer, Gerald; Mayer, Moriz; Beier, Andreas; Brüschweiler, Sven; Fuchs, Julian E; Engelhardt, Harald; Geist, Leonhard; Bader, Gerd; Schörghuber, Julia; Lichtenecker, Roman; Wolkerstorfer, Bernhard; Kessler, Dirk; McConnell, Darryl B; Konrat, Robert

Pharmacological Targets of Kaempferol Within Inflammatory Pathways-A Hint Towards the Central Role of Tryptophan Metabolism

山奈酚在炎症途径中的药理学靶点——色氨酸代谢的核心作用的提示

Stefanie Hofer, Simon Geisler, Rebecca Lisandrelli, Hieu Nguyen Ngoc, Markus Ganzera, Harald Schennach, Dietmar Fuchs, Julian E Fuchs, Johanna M Gostner, Katharina Kurz

Targeted Synthesis of Complex Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-ones by Intramolecular Cyclization of Azomethine Ylides: Highly Potent MDM2-p53 Inhibitors

通过亚胺叶立德的分子内环化靶向合成复杂的螺[3H-吲哚-3,2'-吡咯烷]-2(1H)-酮:高效的MDM2-p53抑制剂

Gollner, Andreas; Weinstabl, Harald; Fuchs, Julian E; Rudolph, Dorothea; Garavel, Geraldine; Hofbauer, Karin S; Karolyi-Oezguer, Jale; Gmaschitz, Gerhard; Hela, Wolfgang; Kerres, Nina; Grondal, Elisabeth; Werni, Patrick; Ramharter, Juergen; Broeker, Joachim; McConnell, Darryl B

An unexpected switch in peptide binding mode: from simulation to substrate specificity

肽结合模式的意外转变:从模拟到底物特异性

Kahler, Ursula; Fuchs, Julian E; Goettig, Peter; Liedl, Klaus R

Crystal structure of Pla l 1 reveals both structural similarity and allergenic divergence within the Ole e 1-like protein family

Pla l 1 的晶体结构揭示了 Ole e 1 样蛋白家族内部的结构相似性和致敏性差异。

Stemeseder, Teresa; Freier, Regina; Wildner, Sabrina; Fuchs, Julian E; Briza, Peter; Lang, Roland; Batanero, Eva; Lidholm, Jonas; Liedl, Klaus R; Campo, Paloma; Hawranek, Thomas; Villalba, Mayte; Brandstetter, Hans; Ferreira, Fatima; Gadermaier, Gabriele