日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Evolutionary turnover of key amino acids explains conservation of function without conservation of sequence in transcriptional activation domains

关键氨基酸的进化更替解释了转录激活结构域中功能保守而序列不保守的现象。

LeBlanc, Claire J; Stefani, Jordan; Soriano, Melvin; Lam, Angelica W Y; Zintel, Marissa A; Kotha, Sanjana R; Chase, Emily P; Pimentel-Solorio, Giovani; Vunnum, Aditya; Hu, Gean; Flug, Katherine L; Fultineer, Aaron; Hummel, Niklas; Staller, Max V

Evolutionary turnover of key amino acids explains conservation of function without conservation of sequence in transcriptional activation domains.

关键氨基酸的进化更替解释了转录激活结构域中功能保守而序列不保守的原因

LeBlanc Claire, Stefani Jordan, Soriano Melvin, Lam Angelica, Zintel Marissa A, Kotha Sanjana R, Chase Emily, Pimentel-Solorio Giovani, Vunnum Aditya, Flug Katherine, Fultineer Aaron, Hummel Niklas, Staller Max V

Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestries

种系变异会导致基于 CRISPR 的实验出现假阴性结果,且不同种族群体中假阴性结果的发生率各不相同。

Misek, Sean A; Fultineer, Aaron; Kalfon, Jeremie; Noorbakhsh, Javad; Boyle, Isabella; Roy, Priyanka; Dempster, Joshua; Petronio, Lia; Huang, Katherine; Saadat, Alham; Green, Thomas; Brown, Adam; Doench, John G; Root, David E; McFarland, James M; Beroukhim, Rameen; Boehm, Jesse S