日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of a non-nucleoside inhibitor that binds to a novel site in the palm domain of the respiratory syncytial virus RNA-dependent RNA polymerase.

发现一种非核苷类抑制剂,可与呼吸道合胞病毒 RNA 依赖性 RNA 聚合酶掌状结构域中的新位点结合

Kalin Jay H, Yin Yanting, Tran Minh T, Piassek Madison, Fung Amy, Grosse Sandrine, Jacoby Edgar, Bhaumik Anusarka, Adhikary Suraj, Miller Robyn, Lemmens Cynthia, Lutter Ferdinand H, Pieters Serge, Cooymans Ludwig, Rombouts Geert, Oehlrich Daniel, Tomaso Sonia, Lozada Kate, Garcia Miguel Osorio, Anson Brandon, De Bruyn Suzanne, Smith-Monroy Constance, Neefs Jean-Marc, Conceição-Neto Nádia, Stoops Bart, van Vlijmen Herman, Patrick Aaron, Yu Xiaodi, Wong Victoria, Krosky Daniel, Abeywickrema Pravien, Mason Stephen, Jin Zhinan, Jonckers Tim H M, Sharma Sujata

Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate

2'-氟-4'-氯甲基胞苷三磷酸选择性抑制呼吸道合胞病毒RNA聚合酶的分子机制

Deval, Jerome; Hong, Jin; Wang, Guangyi; Taylor, Josh; Smith, Lucas K; Fung, Amy; Stevens, Sarah K; Liu, Hong; Jin, Zhinan; Dyatkina, Natalia; Prhavc, Marija; Stoycheva, Antitsa D; Serebryany, Vladimir; Liu, Jyanwei; Smith, David B; Tam, Yuen; Zhang, Qingling; Moore, Martin L; Fearns, Rachel; Chanda, Sushmita M; Blatt, Lawrence M; Symons, Julian A; Beigelman, Leo

Efficiency of incorporation and chain termination determines the inhibition potency of 2'-modified nucleotide analogs against hepatitis C virus polymerase

掺入效率和链终止效率决定了2'-修饰核苷酸类似物对丙型肝炎病毒聚合酶的抑制效力。

Fung, Amy; Jin, Zhinan; Dyatkina, Natalia; Wang, Guangyi; Beigelman, Leo; Deval, Jerome