日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Comprehensive multi-omics analysis reveals WEE1 as a synergistic lethal target with hyperthermia through CDK1 super-activation

综合多组学分析表明，WEE1 通过 CDK1 超激活，成为与高温协同致死的靶点

期刊:Nature Communications
影响因子:14.7
doi:10.1038/s41467-024-46358-w
Xiaohang Yang #, Xingyuan Hu #, Jingjing Yin #, Wenting Li #, Yu Fu, Bin Yang, Junpeng Fan, Funian Lu, Tianyu Qin, Xiaoyan Kang, Xucui Zhuang, Fuxia Li, Rourou Xiao, Tingyan Shi, Kun Song, Jing Li, Gang Chen, Chaoyang Sun
信号转导
Donkey
IgG
发表日期：2024
文献求助 收藏

Genomic profiling of a multi-lineage and multi-passage patient-derived xenograft biobank reflects heterogeneity of ovarian cancer

多谱系和多代患者来源的异种移植生物库的基因组分析反映了卵巢癌的异质性

期刊:Cell Reports Medicine
影响因子:11.7
doi:10.1016/j.xcrm.2024.101631
Tianyu Qin, Zhe Hu, Li Zhang, Funian Lu, Rourou Xiao, Yiting Liu, Junpeng Fan, Ensong Guo, Bin Yang, Yu Fu, Xucui Zhuang, Xiaoyan Kang, Zimeng Wu, Zixuan Fang, Yaoyuan Cui, Xingyuan Hu, Jingjing Yin, Miao Yan, Fuxia Li, Kun Song, Gang Chen, Chaoyang Sun
肿瘤
卵巢癌
发表日期：2024
文献求助 收藏

Multi-omics characterization of silent and productive HPV integration in cervical cancer

宫颈癌中静默性及生产性 HPV 整合的多组学表征

期刊:Cell Genomics
影响因子:11.1
doi:10.1016/j.xgen.2022.100211
Junpeng Fan, Yu Fu, Wenju Peng, Xiong Li, Yuanming Shen, Ensong Guo, Funian Lu, Shengtao Zhou, Si Liu, Bin Yang, Xu Qin, Dianxing Hu, Rourou Xiao, Xi Li, Siqi Yang, Cunzhong Yuan, Yao Shu, He Huang, Ting Wan, Yanan Pi, Shuxiang Wang, Wenjuan Chen, Haixia Wang, Lin Zhong, Li Yuan, Baogang Wen, Beihua
肿瘤
宫颈癌
发表日期：2023
文献求助 收藏

BRD4 inhibition impairs DNA mismatch repair, induces mismatch repair mutation signatures and creates therapeutic vulnerability to immune checkpoint blockade in MMR-proficient tumors

BRD4 抑制会损害 DNA 错配修复，诱导错配修复突变特征，并导致 MMR 功能正常的肿瘤对免疫检查点阻断的治疗脆弱性

期刊:Journal for ImmunoTherapy of Cancer
影响因子:10.3
doi:10.1136/jitc-2022-006070
Yu Fu, Bin Yang, Yaoyuan Cui, Xingyuan Hu, Xi Li, Funian Lu, Tianyu Qin, Li Zhang, Zhe Hu, Ensong Guo, Junpeng Fan, Rourou Xiao, Wenting Li, Xu Qin, Dianxing Hu, Wenju Peng, Jingbo Liu, Beibei Wang, Gordon B Mills, Gang Chen, Chaoyang Sun
信号转导
肿瘤
ChIP
Checkpoint
发表日期：2023
文献求助 收藏

Codelivery of adavosertib and olaparib by tumor-targeting nanoparticles for augmented efficacy and reduced toxicity

通过肿瘤靶向纳米粒子联合输送 adavosertib 和 olaparib 以增强疗效并降低毒性

期刊:Acta Biomaterialia
影响因子:9.4
doi:10.1016/j.actbio.2022.12.021
Wei Wang, Yuxuan Xiong, Xingyuan Hu, Funian Lu, Tianyu Qin, Li Zhang, Ensong Guo, Bin Yang, Yu Fu, Dianxing Hu, JunPeng Fan, Xu Qin, Chen Liu, RouRou Xiao, Gang Chen, Zifu Li, Chaoyang Sun
肿瘤
发表日期：2023
文献求助 收藏

MRE11:p.K464R mutation mediates olaparib resistance by enhancing DNA damage repair in HGSOC

MRE11:p.K464R 突变通过增强 HGSOC 中的 DNA 损伤修复来介导奥拉帕尼耐药性

期刊:Cell and Bioscience
影响因子:6.1
doi:10.1186/s13578-023-01117-0
Xucui Zhuang, Rourou Xiao, Yu Fu, Bin Yang, Junpeng Fan, Funian Lu, Tianyu Qin, Xiaohang Yang, Xingyuan Hu, Jingjing Yin, Wenting Li, Xiaoyan Kang, Gang Chen, Dianxing Hu, Chaoyang Sun
信号转导
WB
发表日期：2023
文献求助 收藏

STAT4, a potential predictor of prognosis, promotes CD8 T‑cell infiltration in ovarian serous carcinoma by inducing CCL5 secretion

STAT4是一种潜在的预后预测因子，它通过诱导CCL5分泌促进CD8 T细胞浸润卵巢浆液性癌。

期刊:Oncology Reports
影响因子:3.8
doi:10.3892/or.2023.8577
Wei Wang # ，Si Liu # ，Funian Lu ，Bin Yang ，Xucui Zhuang ，Jingjing Yin ，Gang Chen ，Chaoyang Sun
免疫/内分泌
T细胞
STAT4
肿瘤免疫
细胞生物学
JAK/STAT
肿瘤
T细胞
CCL5
CD8
发表日期：2023
文献求助 收藏

WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway

WEE1 抑制通过激活 ERV 和 dsRNA 通路诱导抗肿瘤免疫

期刊:Journal of Experimental Medicine
影响因子:12.6
doi:10.1084/jem.20210789
Ensong Guo #, Rourou Xiao #, Yifan Wu #, Funian Lu #, Chen Liu, Bin Yang, Xi Li, Yu Fu, Zizhuo Wang, Yuan Li, Yuhan Huang, Fuxia Li, Xue Wu, Lixin You, Tianyu Qin, Yiling Lu, Xiaoyuan Huang, Ding Ma, Gordon B Mills, Chaoyang Sun, Gang Chen
信号转导
肿瘤
IHC
Human
CGAS
发表日期：2022
文献求助 收藏

Spatial heterogeneity of infiltrating T cells in high-grade serous ovarian cancer revealed by multi-omics analysis

多组学分析揭示高级别浆液性卵巢癌中浸润 T 细胞的空间异质性

期刊:Cell Reports Medicine
影响因子:11.7
doi:10.1016/j.xcrm.2022.100856
Bin Yang, Xiong Li, Wei Zhang, Junpeng Fan, Yong Zhou, Wenting Li, Jingjing Yin, Xiaohang Yang, Ensong Guo, Xi Li, Yu Fu, Si Liu, Dianxing Hu, Xu Qin, Yingyu Dou, Rourou Xiao, Funian Lu, Zizhuo Wang, Tianyu Qin, Wei Wang, Qinghua Zhang, Shuaicheng Li, Ding Ma, Gordon B Mills, Gang Chen, Chaoyang Sun
免疫
细胞生物学
肿瘤
卵巢癌
T细胞
肿瘤细胞
FlowCytometry
Human
CD8
发表日期：2022
文献求助 收藏

Inhibiting the IRE1α Axis of the Unfolded Protein Response Enhances the Antitumor Effect of AZD1775 in TP53 Mutant Ovarian Cancer

抑制未折叠蛋白反应的 IRE1α 轴可增强 AZD1775 在 TP53 突变卵巢癌中的抗肿瘤作用

期刊:Advanced Science
影响因子:
doi:10.1002/advs.202105469
Rourou Xiao, Lixin You, Li Zhang, Xichen Guo, Ensong Guo, Faming Zhao, Bin Yang, Xi Li, Yu Fu, Funian Lu, Zizhuo Wang, Chen Liu, Wenju Peng, Wenting Li, Xiaohang Yang, Yingyu Dou, Jingbo Liu, Wei Wang, Tianyu Qin, Yaoyuan Cui, Xiaoxiao Zhang, Fuxia Li, Yang Jin, Qingping Zeng, Beibei Wang, Gordon B
肿瘤
卵巢癌
WB
发表日期：2022
文献求助 收藏