日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Human iPSC neurons display activity-dependent neurotransmitter secretion: aberrant catecholamine levels in schizophrenia neurons

人类诱导多能干细胞神经元表现出活动依赖性神经递质分泌:精神分裂症神经元中儿茶酚胺水平异常

Hook, Vivian; Brennand, Kristen J; Kim, Yongsung; Toneff, Thomas; Funkelstein, Lydiane; Lee, Kelly C; Ziegler, Michael; Gage, Fred H

Pyroglutamate-amyloid-β and glutaminyl cyclase are colocalized with amyloid-β in secretory vesicles and undergo activity-dependent, regulated secretion

焦谷氨酸-β淀粉样蛋白和谷氨酰环化酶与β淀粉样蛋白共定位于分泌囊泡中,并经历活性依赖性的、受调控的分泌过程。

Cynis, Holger; Funkelstein, Lydiane; Toneff, Thomas; Mosier, Charles; Ziegler, Michael; Koch, Birgit; Demuth, Hans-Ulrich; Hook, Vivian

Beta-amyloid peptides undergo regulated co-secretion with neuropeptide and catecholamine neurotransmitters

β-淀粉样肽与神经肽和儿茶酚胺神经递质一起进行受调控的共同分泌

Thomas Toneff, Lydiane Funkelstein, Charles Mosier, Armen Abagyan, Michael Ziegler, Vivian Hook

Spinal astrocytes produce and secrete dynorphin neuropeptides

脊髓星形胶质细胞产生并分泌强啡肽神经肽

Andrew Wahlert, Lydiane Funkelstein, Bethany Fitzsimmons, Tony Yaksh, Vivian Hook

Human cathepsin V protease participates in production of enkephalin and NPY neuropeptide neurotransmitters

人类组织蛋白酶 V 蛋白酶参与脑啡肽和 NPY 神经肽神经递质的产生

Lydiane Funkelstein, W Douglas Lu, Britta Koch, Charles Mosier, Thomas Toneff, Laurent Taupenot, Daniel T O'Connor, Thomas Reinheckel, Christoph Peters, Vivian Hook

Cathepsin H functions as an aminopeptidase in secretory vesicles for production of enkephalin and galanin peptide neurotransmitters

组织蛋白酶H在分泌囊泡中作为氨肽酶发挥作用,用于产生脑啡肽和加兰素肽类神经递质。

Lu, Weiya Douglas; Funkelstein, Lydiane; Toneff, Thomas; Reinheckel, Thomas; Peters, Christoph; Hook, Vivian

Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease

分泌囊泡中的半胱氨酸组织蛋白酶产生活性肽:组织蛋白酶L生成肽类神经递质,组织蛋白酶B生成阿尔茨海默病β-淀粉样蛋白。

Hook, Vivian; Funkelstein, Lydiane; Wegrzyn, Jill; Bark, Steven; Kindy, Mark; Hook, Gregory

Proteomics of dense core secretory vesicles reveal distinct protein categories for secretion of neuroeffectors for cell-cell communication

致密核心分泌囊泡的蛋白质组学揭示了用于细胞间通讯的神经效应物分泌的不同蛋白质类别

Jill L Wegrzyn, Steven J Bark, Lydiane Funkelstein, Charles Mosier, Angel Yap, Parsa Kazemi-Esfarjani, Albert R La Spada, Christina Sigurdson, Daniel T O'Connor, Vivian Hook

Neuropeptidomic components generated by proteomic functions in secretory vesicles for cell-cell communication

神经肽组学成分由分泌囊泡中的蛋白质组学功能产生,用于细胞间通讯。

Hook, Vivian; Bark, Steven; Gupta, Nitin; Lortie, Mark; Lu, Weiya D; Bandeira, Nuno; Funkelstein, Lydiane; Wegrzyn, Jill; O'Connor, Daniel T; Pevzner, Pavel

Unique biological function of cathepsin L in secretory vesicles for biosynthesis of neuropeptides

组织蛋白酶L在分泌囊泡中独特的生物学功能,参与神经肽的生物合成

Funkelstein, Lydiane; Beinfeld, Margery; Minokadeh, Ardalan; Zadina, James; Hook, Vivian