日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Human iPSC neurons display activity-dependent neurotransmitter secretion: aberrant catecholamine levels in schizophrenia neurons

人类诱导多能干细胞神经元表现出活动依赖性神经递质分泌:精神分裂症神经元中儿茶酚胺水平异常

Hook, Vivian; Brennand, Kristen J; Kim, Yongsung; Toneff, Thomas; Funkelstein, Lydiane; Lee, Kelly C; Ziegler, Michael; Gage, Fred H

Pyroglutamate-amyloid-β and glutaminyl cyclase are colocalized with amyloid-β in secretory vesicles and undergo activity-dependent, regulated secretion

焦谷氨酸-β淀粉样蛋白和谷氨酰环化酶与β淀粉样蛋白共定位于分泌囊泡中,并经历活性依赖性的、受调控的分泌过程。

Cynis, Holger; Funkelstein, Lydiane; Toneff, Thomas; Mosier, Charles; Ziegler, Michael; Koch, Birgit; Demuth, Hans-Ulrich; Hook, Vivian

Cathepsin H functions as an aminopeptidase in secretory vesicles for production of enkephalin and galanin peptide neurotransmitters

组织蛋白酶H在分泌囊泡中作为氨肽酶发挥作用,用于产生脑啡肽和加兰素肽类神经递质。

Lu, Weiya Douglas; Funkelstein, Lydiane; Toneff, Thomas; Reinheckel, Thomas; Peters, Christoph; Hook, Vivian

Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease

分泌囊泡中的半胱氨酸组织蛋白酶产生活性肽:组织蛋白酶L生成肽类神经递质,组织蛋白酶B生成阿尔茨海默病β-淀粉样蛋白。

Hook, Vivian; Funkelstein, Lydiane; Wegrzyn, Jill; Bark, Steven; Kindy, Mark; Hook, Gregory

Neuropeptidomic components generated by proteomic functions in secretory vesicles for cell-cell communication

神经肽组学成分由分泌囊泡中的蛋白质组学功能产生,用于细胞间通讯。

Hook, Vivian; Bark, Steven; Gupta, Nitin; Lortie, Mark; Lu, Weiya D; Bandeira, Nuno; Funkelstein, Lydiane; Wegrzyn, Jill; O'Connor, Daniel T; Pevzner, Pavel

Unique biological function of cathepsin L in secretory vesicles for biosynthesis of neuropeptides

组织蛋白酶L在分泌囊泡中独特的生物学功能,参与神经肽的生物合成

Funkelstein, Lydiane; Beinfeld, Margery; Minokadeh, Ardalan; Zadina, James; Hook, Vivian

Cathepsin L plays a major role in cholecystokinin production in mouse brain cortex and in pituitary AtT-20 cells: protease gene knockout and inhibitor studies.

组织蛋白酶 L 在小鼠大脑皮层和垂体 AtT-20 细胞中胆囊收缩素的产生中起着重要作用:蛋白酶基因敲除和抑制剂研究

Beinfeld Margery C, Funkelstein Lydiane, Foulon Thierry, Cadel Sandrine, Kitagawa Kouki, Toneff Thomas, Reinheckel Thomas, Peters Christoph, Hook Vivian

Proteases for processing proneuropeptides into peptide neurotransmitters and hormones

用于将前神经肽加工成肽类神经递质和激素的蛋白酶

Hook, Vivian; Funkelstein, Lydiane; Lu, Douglas; Bark, Steven; Wegrzyn, Jill; Hwang, Shin-Rong

Cathepsin L participates in the production of neuropeptide Y in secretory vesicles, demonstrated by protease gene knockout and expression

组织蛋白酶L参与分泌囊泡中神经肽Y的生成,这已通过蛋白酶基因敲除和表达实验得到证实。

Funkelstein, Lydiane; Toneff, Thomas; Hwang, Shin-Rong; Reinheckel, Thomas; Peters, Christoph; Hook, Vivian