日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease

外切核酸酶 TREX1 可降解双链 DNA,从而预防自发性狼疮样炎症性疾病。

Grieves, Jessica L; Fye, Jason M; Harvey, Scott; Grayson, Jason M; Hollis, Thomas; Perrino, Fred W

The TREX1 C-terminal region controls cellular localization through ubiquitination.

TREX1 C 端区域通过泛素化控制细胞定位

Orebaugh Clinton D, Fye Jason M, Harvey Scott, Hollis Thomas, Wilkinson John C, Perrino Fred W

The TREX1 exonuclease R114H mutation in Aicardi-Goutières syndrome and lupus reveals dimeric structure requirements for DNA degradation activity

Aicardi-Goutières综合征和狼疮中的TREX1核酸外切酶R114H突变揭示了DNA降解活性所需的二聚体结构。

Orebaugh, Clinton D; Fye, Jason M; Harvey, Scott; Hollis, Thomas; Perrino, Fred W