日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CRISPR-Cas9 Screening Identifies Resistance Mechanisms to KRAS Inhibition in Pancreatic Cancer

CRISPR-Cas9筛选揭示胰腺癌中KRAS抑制的耐药机制

Long, Szu-Aun; Todd, Haley; Goodhart, Grace; Chang, Wen-Hsuan; Amparo, Amber M; Bridgens, Rachel; Dilly, Julien; Park, Se Jun; Beal, Robert M; Shehadeh, Sara M; Satyadi, Megan A; Trivedi, Vidushi K; Ackermann, Sarah E; Mukherjee, Raivath; Goodwin, Craig M; Edwards, A Cole; Stalnecker, Clint A; Greis, Kenneth D; Aguirre, Andrew J; Hobbs, G Aaron; Bryant, Kirsten L; Ahmad, Syed A; Cox, Adrienne D; Der, Channing J; Waters, Andrew M

KRASG12R-Mutant Pancreatic Cancer Features Limited ERK/MAPK Transcriptional Activity and a Distinctive Tumor Microenvironment

KRASG12R突变型胰腺癌具有ERK/MAPK转录活性受限和独特的肿瘤微环境。

Burge, Rachel A; Le Roux, Ozgun; Popow, Olesja; Spadafora, Victoria K; Rajesh, Christabelle; Adair, Sara J; Bialousow, Lucas; Murphy, Cailey; Saberi, Samaneh; Vaena, Silvia G; Taquey, Margaret C; Allen, Sarah; Han, Lu; Helke, Kristi L; Sharma, Sudarshana; Ostrowski, Michael C; Guttridge, Denis C; Dincman, Toros A; Bauer, Todd W; Kashatus, David F; McFall, Thomas; Haigis, Kevin M; Hollingsworth, Michael A; Counter, Christopher M; Der, Channing J; Hobbs, G Aaron

Mutant and Wild-Type RAS Cross-talk and Stoichiometric Deficiencies Are Determinants of Sensitivity to Targeted Therapies in KRASG12R Pancreatic Ductal Adenocarcinoma.

突变型和野生型 RAS 串扰和化学计量缺陷是 KRASG12R 胰腺导管腺癌对靶向治疗敏感性的决定因素。

Kamgar Mandana, Hobbes G Aaron, Davidson Raven, Dorbin Daniel, Herrera Juliannie, Langenheim John F, Burge Rachel A, Aldakkak Mohammed, Conrardy Ryan D, Szabo Aniko, Thalji Sam Z, Mayer Bradley, Grahl Justin J, Chung Brian Y, Phan Alexandria, Thomas James P, Seo Y David, Evans Douglas B, Christians Kathleen K, Erickson Beth, Hall William A, George Ben, Tsai Susan, Lytle Nikki K, Der Channing J, Kurzrock Razelle, McFall Thomas

PTEN Oxidation Promotes Constitutive PI3K Signaling and Inducible Macropinocytosis in Pancreatic Cancer

PTEN氧化促进胰腺癌中组成型PI3K信号传导和诱导型巨胞饮作用

Burge, Rachel A; Bialousow, Lucas; Linke, Amanda J; Coalson, Hannah S; Adair, Sara J; Sundararaj, Kamala; Smith, Merissa; Bumbleburg, Cameron; Bauer, Todd W; Kashatus, David F; Hobbs, G Aaron

Secreted frizzled-related protein 2 monoclonal antibody-mediated IFN-ϒ reprograms tumor-associated macrophages to suppress triple negative breast cancer.

分泌型卷曲相关蛋白 2 单克隆抗体介导的 IFN-γ 重编程肿瘤相关巨噬细胞以抑制三阴性乳腺癌。

Hsu Lillian, Siegel Julie, Nasarre Patrick, Oberholtzer Nathaniel, Mukherjee Rupak, Hilliard Eleanor, Chakraborty Paramita, Burge Rachel A, O'Quinn Elizabeth C, Sweatt Olivia, Kassir Mohamed Faisal, Hobbs G Aaron, Ostrowski Michael, Broome Ann-Marie, Mehrotra Shikhar, Klauber-DeMore Nancy

Modulating the CXCR2 Signaling Axis Using Engineered Chemokine Fusion Proteins to Disrupt Myeloid Cell Infiltration in Pancreatic Cancer

利用工程化趋化因子融合蛋白调节CXCR2信号通路以破坏胰腺癌中的髓系细胞浸润

Benjamin N Christopher ,Lena Golick ,Ashton Basar ,Leticia Reyes ,Reeder M Robinson ,Aaron O Angerstein ,Carsten Krieg ,G Aaron Hobbs ,Denis C Guttridge ,John P O'Bryan ,Nathan G Dolloff

Pancreatic Cells Are Resistant to KRASQ61L Expression due to Hyperactive ERK/MAPK Signaling and Apoptosis Induction

胰腺细胞由于ERK/MAPK信号通路过度活跃和细胞凋亡诱导而对KRASQ61L表达具有抵抗性。

Burge, Rachel A; Bialousow, Lucas; McFall, Thomas; Bamonte, Logan; Johnson, Grayson; Smith, Merissa; Vaena, Silvia G; Comte-Walters, Susana; Ball, Lauren E; Berto, Stefano; O'Bryan, John P; Hobbs, G Aaron

PNMA2 forms immunogenic non-enveloped virus-like capsids associated with paraneoplastic neurological syndrome

PNMA2 形成免疫原性无包膜病毒样衣壳,与副肿瘤性神经综合征相关。

Junjie Xu ,Simon Erlendsson ,Manvendra Singh ,G Aaron Holling ,Matthew Regier ,Iosune Ibiricu ,Jenifer Einstein ,Michael P Hantak ,Gregory S Day ,Amanda L Piquet ,Tammy L Smith ,Stacey L Clardy ,Alexandra M Whiteley ,Cédric Feschotte ,John A G Briggs ,Jason D Shepherd

CD8+ T cell metabolic flexibility elicited by CD28-ARS2 axis-driven alternative splicing of PKM supports antitumor immunity

CD28-ARS2 轴驱动的 PKM 可变剪接引起的 CD8+ T 细胞代谢灵活性支持抗肿瘤免疫

G Aaron Holling, Colin A Chavel, Anand P Sharda, Mackenzie M Lieberman, Caitlin M James, Shivana M Lightman, Jason H Tong, Guanxi Qiao, Tiffany R Emmons, Thejaswini Giridharan, Shengqi Hou, Andrew M Intlekofer, Richard M Higashi, Teresa W M Fan, Andrew N Lane, Kevin H Eng, Brahm H Segal, Elizabeth A

HSP70-mediated mitochondrial dynamics and autophagy represent a novel vulnerability in pancreatic cancer

HSP70介导的线粒体动力学和自噬代表了胰腺癌的一种新的脆弱性

Ferretti, Giulia D S; Quaas, Colleen E; Bertolini, Irene; Zuccotti, Alessandro; Saatci, Ozge; Kashatus, Jennifer A; Sharmin, Salma; Lu, David Y; Poli, Adi Narayana Reddy; Quesnelle, Abigail F; Rodriguez-Blanco, Jezabel; de Cubas, Aguirre A; Hobbs, G Aaron; Liu, Qin; O'Bryan, John P; Salvino, Joseph M; Kashatus, David F; Sahin, Ozgur; Barnoud, Thibaut