日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Aberrant CDK4/6-driven cell-cycle reentry drives neuronal loss and defines a therapeutic target in C9orf72 ALS/FTD

CDK4/6 异常驱动的细胞周期重入导致神经元丢失,并为 C9orf72 ALS/FTD 的治疗提供了一个靶点。

Ling Lian,Hayley Robinson,Noah Daniels,G Aleph Prieto,Gunnar H D Poplawski,Rodrigo Lopez-Gonzalez

Hippocampal synaptic failure is an early event in experimental parkinsonism with subtle cognitive deficit

海马突触衰竭是实验性帕金森病的早期事件,伴有轻微的认知缺陷

Arantzazu Belloso-Iguerategui, Marta Zamarbide, Leyre Merino-Galan, Tatiana Rodríguez-Chinchilla, Belén Gago, Enrique Santamaria, Joaquín Fernández-Irigoyen, Carl W Cotman, G Aleph Prieto, Ana Quiroga-Varela, María Cruz Rodríguez-Oroz

The role of aging and brain-derived neurotrophic factor signaling in expression of base excision repair genes in the human brain

衰老和脑源性神经营养因子信号在人类大脑碱基切除修复基因表达中的作用

Sofie Lautrup, Camilla Myrup Holst, Anne Yde, Stine Asmussen, Vibeke Thinggaard, Knud Larsen, Lisbeth Schmidt Laursen, Mette Richner, Christian B Vaegter, G Aleph Prieto, Nicole Berchtold, Carl W Cotman, Tinna Stevnsner

Neurological manifestations with jugular vein thrombosis linked to an inflammatory profile may be a sequela of long COVID

与炎症相关的颈静脉血栓形成引起的神经系统症状可能是新冠长期后遗症。

Mendoza-Portillo, Elizabeth; Aleman-Navarro, Estefania; Prieto, G Aleph; Rosenstein, Yvonne; Lozano-Nuevo, Jose J; Perez-Lopez, Araceli

Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease

基因表达和功能缺陷是阿尔茨海默病人类模型中TREM2敲除小胶质细胞反应的根本原因

Amanda McQuade ,You Jung Kang ,Jonathan Hasselmann ,Amit Jairaman ,Alexandra Sotelo ,Morgan Coburn ,Sepideh Kiani Shabestari ,Jean Paul Chadarevian ,Gianna Fote ,Christina H Tu ,Emma Danhash ,Jorge Silva ,Eric Martinez ,Carl Cotman ,G Aleph Prieto ,Leslie M Thompson ,Joan S Steffan ,Ian Smith ,Hayk Davtyan ,Michael Cahalan ,Hansang Cho ,Mathew Blurton-Jones

Inhibition of LTP-Induced Translation by IL-1β Reduces the Level of Newly Synthesized Proteins in Hippocampal Dendrites

IL-1β 抑制 LTP 诱导的翻译可降低海马树突中新合成蛋白质的水平

G Aleph Prieto, Erica D Smith, Liqi Tong, Michelle Nguyen, Carl W Cotman

Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus

通过腺相关病毒介导的基因转移导致细胞内和细胞外 β-淀粉样蛋白过度表达,损害海马记忆力和突触可塑性

Stefania Forner, Alessandra C Martini, G Aleph Prieto, Cindy T Dang, Carlos J Rodriguez-Ortiz, Jorge Mauricio Reyes-Ruiz, Laura Trujillo-Estrada, Celia da Cunha, Elizabeth J Andrews, Jimmy Phan, Jordan Vu Ha, Allissa V Z D Chang, Yona Levites, Pedro E Cruz, Rahasson Ager, Rodrigo Medeiros, Masashi K

TNFα and IL-1β but not IL-18 Suppresses Hippocampal Long-Term Potentiation Directly at the Synapse

TNFα 和 IL-1β(而非 IL-18)直接抑制突触处的海马长期增强

G Aleph Prieto, Liqi Tong, Erica D Smith, Carl W Cotman

Hippocampal gene expression patterns linked to late-life physical activity oppose age and AD-related transcriptional decline

与晚年体育活动相关的海马基因表达模式能够对抗年龄和阿尔茨海默病相关的转录衰退。

Berchtold, Nicole C; Prieto, G Aleph; Phelan, Michael; Gillen, Daniel L; Baldi, Pierre; Bennett, David A; Buchman, Aron S; Cotman, Carl W

IL-1β suppresses cLTP-induced surface expression of GluA1 and actin polymerization via ceramide-mediated Src activation

IL-1β 通过神经酰胺介导的 Src 激活抑制 cLTP 诱导的 GluA1 表面表达和肌动蛋白聚合

Liqi Tong, G Aleph Prieto, Carl W Cotman