日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Antisense Dipeptide Repeat Proteins Drive Widescale Purine Metabolism Aberration in C9orf72 Amyotrophic Lateral Sclerosis via ADA

反义二肽重复蛋白通过ADA驱动C9orf72肌萎缩侧索硬化症中广泛的嘌呤代谢异常。

Benjamin Hall,Lydia Castelli,Adrian Higginbottom,Jingxuan He,Ling-Nan Zou,Heather Walker,Miriam Yagüe-Capilla,Kari E Wong,David J Burrows,Jonathan George,Keaton Hamer,Jenny M Tanner,Ergita Kyrgiou-Balli,Rees Ross,Herbie Garland,Erin Tonkiss,Rachel George,Christopher P Webster,Emma F Smith,Hannah O Timmons,Jess Allsop,Nikolas Stefanidis,Billie D Ward,Ya-Hui Lin,J Robin Highley,Mimoun Azzouz,Ryan J H West,Sean G Rudd,Kurt J De Vos,Pamela J Shaw,Guillaume M Hautbergue,Scott P Allen

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel

通过综合筛选流程鉴定和评价针对 dNTPase SAMHD1 的小分子抑制剂

Si Min Zhang ,Cynthia B J Paulin ,Huazhang Shu ,Miriam Yagüe-Capilla ,Maurice Michel ,Petra Marttila ,Florian Ortis ,Henri Colyn Bwanika ,Christopher Dirks ,Rajagopal Papagudi Venkatram ,Elisée Wiita ,Ann-Sofie Jemth ,Ingrid Almlöf ,Olga Loseva ,Femke M Hormann ,Tobias Koolmeister ,Erika Linde ,Sun Lee ,Sabin Llona-Minguez ,Martin Haraldsson ,Hanna Axelsson ,Kia Strömberg ,Evert J Homan ,Martin Scobie ,Thomas Lundbäck ,Thomas Helleday ,Sean G Rudd

Extended X-ray absorption fine structure of dynamically-compressed copper up to 1 terapascal

动态压缩至 1 太帕斯卡的铜的扩展 X 射线吸收精细结构

Sio, H; Krygier, A; Braun, D G; Rudd, R E; Bonev, S A; Coppari, F; Millot, M; Fratanduono, D E; Bhandarkar, N; Bitter, M; Bradley, D K; Efthimion, P C; Eggert, J H; Gao, L; Hill, K W; Hood, R; Hsing, W; Izumi, N; Kemp, G; Kozioziemski, B; Landen, O L; Le Galloudec, K; Lockard, T E; Mackinnon, A; McNaney, J M; Ose, N; Park, H-S; Remington, B A; Schneider, M B; Stoupin, S; Thorn, D B; Vonhof, S; Wu, C J; Ping, Y

Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells

突变 p53 活化化合物 APR-246 与天冬酰胺酶协同作用,抑制急性淋巴细胞白血病细胞的生长

Sophia Ceder, Sofi E Eriksson, Ying Yu Liang, Emarndeena H Cheteh, Si Min Zhang, Kenji M Fujihara, Julie Bianchi, Vladimir J N Bykov, Lars Abrahmsen, Nicholas J Clemons, Pär Nordlund, Sean G Rudd, Klas G Wiman

Drug synergy scoring using minimal dose response matrices

使用最小剂量反应矩阵进行药物协同作用评分

Petri Mäkelä, Si Min Zhang, Sean G Rudd

Development of a chemical probe against NUDT15

针对NUDT15的化学探针的开发

Si Min Zhang # ,Matthieu Desroses # ,Anna Hagenkort # ,Nicholas C K Valerie ,Daniel Rehling ,Megan Carter ,Olov Wallner ,Tobias Koolmeister ,Adam Throup ,Ann-Sofie Jemth ,Ingrid Almlöf ,Olga Loseva ,Thomas Lundbäck ,Hanna Axelsson ,Shruti Regmi ,Antonio Sarno ,Andreas Krämer ,Linda Pudelko ,Lars Bräutigam ,Azita Rasti ,Mona Göttmann ,Elisée Wiita ,Juliane Kutzner ,Torsten Schaller ,Christina Kalderén ,Armando Cázares-Körner ,Brent D G Page ,Rosa Krimpenfort ,Saeed Eshtad ,Mikael Altun ,Sean G Rudd ,Stefan Knapp ,Martin Scobie ,Evert J Homan ,Ulrika Warpman Berglund ,Pål Stenmark ,Thomas Helleday

MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG

MTH1 抑制剂 TH588 干扰有丝分裂进程并诱导有丝分裂依赖性基因组 8-oxodG 积累

Sean G Rudd, Helge Gad, Kumar Sanjiv, Nuno Amaral, Anna Hagenkort, Petra Groth, Cecilia E Ström, Oliver Mortusewicz, Ulrika Warpman Berglund, Thomas Helleday

Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy

核苷酸还原酶抑制剂抑制 SAMHD1 ara-CTPase 活性,增强阿糖胞苷疗效

Sean G Rudd #, Nikolaos Tsesmetzis #, Kumar Sanjiv #, Cynthia Bj Paulin, Lakshmi Sandhow, Juliane Kutzner, Ida Hed Myrberg, Sarah S Bunten, Hanna Axelsson, Si Min Zhang, Azita Rasti, Petri Mäkelä, Si'Ana A Coggins, Sijia Tao, Sharda Suman, Rui M Branca, Georgios Mermelekas, Elisée Wiita, Sun Lee, Ju

Cell Cycle Profiling Reveals Protein Oscillation, Phosphorylation, and Localization Dynamics

细胞周期分析揭示蛋白质振荡、磷酸化和定位动态

Patrick Herr, Johan Boström, Eric Rullman, Sean G Rudd, Mattias Vesterlund, Janne Lehtiö, Thomas Helleday, Gianluca Maddalo, Mikael Altun

Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

靶向 NUDT5 抑制剂阻断乳腺癌细胞中的激素信号传导

Brent D G Page, Nicholas C K Valerie, Roni H G Wright, Olov Wallner, Rebecka Isaksson, Megan Carter, Sean G Rudd, Olga Loseva, Ann-Sofie Jemth, Ingrid Almlöf, Jofre Font-Mateu, Sabin Llona-Minguez, Pawel Baranczewski, Fredrik Jeppsson, Evert Homan, Helena Almqvist, Hanna Axelsson, Shruti Regmi, Anna