日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Multi-tiered chemical proteomic maps of tryptoline acrylamide-protein interactions in cancer cells

癌细胞中色氨酸丙烯酰胺-蛋白质相互作用的多层化学蛋白质组学图谱

Evert Njomen,Rachel E Hayward,Kristen E DeMeester,Daisuke Ogasawara,Melissa M Dix,Tracey Nguyen,Paige Ashby,Gabriel M Simon,Stuart L Schreiber,Bruno Melillo,Benjamin F Cravatt

Proteomic discovery of chemical probes that perturb protein complexes in human cells

蛋白质组学发现可扰乱人类细胞中蛋白质复合物的化学探针

Michael R Lazear,Jarrett R Remsberg,Martin G Jaeger,Katherine Rothamel,Hsuan-Lin Her,Kristen E DeMeester,Evert Njomen,Simon J Hogg,Jahan Rahman,Landon R Whitby,Sang Joon Won,Michael A Schafroth,Daisuke Ogasawara,Minoru Yokoyama,Garrett L Lindsey,Haoxin Li,Jason Germain,Sabrina Barbas,Joan Vaughan,Thomas W Hanigan,Vincent F Vartabedian,Christopher J Reinhardt,Melissa M Dix,Seong Joo Koo,Inha Heo,John R Teijaro,Gabriel M Simon,Brahma Ghosh,Omar Abdel-Wahab,Kay Ahn,Alan Saghatelian,Bruno Melillo,Stuart L Schreiber,Gene W Yeo,Benjamin F Cravatt

Assigning functionality to cysteines by base editing of cancer dependency genes

通过对癌症依赖性基因进行碱基编辑,赋予半胱氨酸功能

Haoxin Li, Tiantai Ma, Jarrett R Remsberg, Sang Joon Won, Kristen E DeMeester, Evert Njomen, Daisuke Ogasawara, Kevin T Zhao, Tony P Huang, Bingwen Lu, Gabriel M Simon, Bruno Melillo, Stuart L Schreiber, Jens Lykke-Andersen, David R Liu, Benjamin F Cravatt

Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine

针对亚型限制性变构半胱氨酸的JAK1选择性抑制剂

Madeline E Kavanagh # ,Benjamin D Horning # ,Roli Khattri ,Nilotpal Roy ,Justine P Lu ,Landon R Whitby ,Elva Ye ,Jaclyn C Brannon ,Albert Parker ,Joel M Chick ,Christie L Eissler ,Ashley J Wong ,Joe L Rodriguez ,Socorro Rodiles ,Kim Masuda ,John R Teijaro ,Gabriel M Simon ,Matthew P Patricelli ,Benjamin F Cravatt

An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells

人类原代 T 细胞中亲电试剂-半胱氨酸相互作用的活性引导图谱

Ekaterina V Vinogradova, Xiaoyu Zhang, David Remillard, Daniel C Lazar, Radu M Suciu, Yujia Wang, Giulia Bianco, Yu Yamashita, Vincent M Crowley, Michael A Schafroth, Minoru Yokoyama, David B Konrad, Kenneth M Lum, Gabriel M Simon, Esther K Kemper, Michael R Lazear, Sifei Yin, Megan M Blewett, Melis

Parallel Murine and Human Plaque Proteomics Reveals Pathways of Plaque Rupture

小鼠和人类斑块蛋白质组学平行研究揭示斑块破裂的途径

Tomáš Vaisar #, Jie H Hu #, Nathan Airhart, Kate Fox, Jay Heinecke, Roberto F Nicosia, Ted Kohler, Zachary E Potter, Gabriel M Simon, Melissa M Dix, Benjamin F Cravatt, Sina A Gharib #, David A Dichek #

Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan

药理学融合揭示了调节秀丽隐杆线虫寿命的脂质通路

Alice L Chen, Kenneth M Lum, Pablo Lara-Gonzalez, Daisuke Ogasawara, Armand B Cognetta 3rd, Alan To, William H Parsons, Gabriel M Simon, Arshad Desai, Michael Petrascheck, Liron Bar-Peled, Benjamin F Cravatt2

ABHD4 regulates multiple classes of N-acyl phospholipids in the mammalian central nervous system

ABHD4 调节哺乳动物中枢神经系统中多种 N-酰基磷脂

Hyeon-Cheol Lee, Gabriel M Simon, Benjamin F Cravatt

Monoacylglycerol lipase inhibitor JZL184 improves behavior and neural properties in Ts65Dn mice, a model of down syndrome

单酰甘油脂肪酶抑制剂 JZL184 可改善唐氏综合症模型 Ts65Dn 小鼠的行为和神经特性

Larisa V Lysenko, Jeesun Kim, Cassandra Henry, Anna Tyrtyshnaia, Rebecca A Kohnz, Francisco Madamba, Gabriel M Simon, Natalia E Kleschevnikova, Daniel K Nomura, R Alan B Ezekowitz, Alexander M Kleschevnikov

Anandamide biosynthesis catalyzed by the phosphodiesterase GDE1 and detection of glycerophospho-N-acyl ethanolamine precursors in mouse brain

磷酸二酯酶 GDE1 催化的花生四烯乙醇胺生物合成及小鼠脑中甘油磷酸-N-酰基乙醇胺前体的检测

Gabriel M Simon, Benjamin F Cravatt