日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

RUNX1 and YY1 modulate neuronal fate and energy metabolism in Alzheimer's disease

RUNX1 和 YY1 在阿尔茨海默病中调节神经元命运和能量代谢

Lucciola, Raffaella; Herdy, Joseph R; Vajaphattana, Yatavee; Karbacher, Lukas; Sabedot, Thais S; Cuoco, Michael S; Traxler, Larissa; Kang, Austin; Reynolds, Mack; Jones, Jeffrey R; Schafer, Simon T; Mertens, Jerome; Gage, Fred H

DNA damage drives a unique, Alzheimer's disease-relevant senescent state in neurons

DNA损伤会导致神经元出现一种独特的、与阿尔茨海默病相关的衰老状态。

Hughes, Jun-Wei B; Sandholm, Anja; Croll, Duncan; Senchyna, Fiona; Schneider, Kevin; Butterfield, Rachel; McHugh, Tyne L M; Brown, Ian; Deguchi, Hideto; Hilsabeck, Tyler A U; Mak, Sally; Wilson, Kenneth A; Davtyan, Hayk; Blurton-Jones, Mathew; Herdy, Joseph; Higuchi-Sanabria, Ryo; Gage, Fred H; Furman, David; Ellerby, Lisa M; Desprez, Pierre-Yves; Campisi, Judith

ROS-dependent localization of glycolytic enzymes to mitochondria.

ROS依赖性糖酵解酶定位至线粒体

Esparza-Moltó Pau B, Goswami Arvind V, Bozkurt Süleyman, Münch Christian, Newman Laura E, Moyzis Alexandra G, Rojas Gladys R, Guan Deann, Jones Jeffrey R, Gage Fred H, Shadel Gerald S

Synaptotagmin-7 deficit causes insulin hypoactivity and contributes to behavioral alterations in mice.

突触结合蛋白-7 缺乏会导致小鼠胰岛素活性降低,并导致小鼠行为改变

Liu Yao-Nan, Wang Qiu-Wen, Lu Si-Yao, Shen Wei, Guo Chongye, Xing Zhikai, Li Chang, Sun Shan, Sui Sen-Fang, Mi Shuangli, Gage Fred H, Yao Jun

Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice

长期脑啡肽酶基因转移与APP转基因小鼠细胞内Aβ水平降低和行为改善相关。

Spencer, Brian; Marr, Robert A; Rockenstein, Edward; Crews, Leslie; Adame, Anthony; Potkar, Rewati; Patrick, Christina; Gage, Fred H; Verma, Inder M; Masliah, Eliezer

Retrotransposon Activation in the Aged and Alzheimer's Disease Brain Examined by Nanopore Long-read DNA Sequencing

利用纳米孔长读长DNA测序技术检测老年人和阿尔茨海默病患者脑组织中的逆转录转座子激活情况

Kelsey, Maxfield M G; Chongtham, Anjalika; LaCava, John; Taylor, Martin S; Boeke, Jef D; Gage, Fred H; Seluanov, Andrei; Gorbunova, Vera; Pereira, Ana C; Sedivy, John M

CK2 inhibition suppresses glial inflammation in the brain

CK2抑制剂可抑制大脑中的神经胶质炎症

Da Silva, Ioana I N; Ramirez, Desiree; Parylak, Sarah L; Wallace, Leslie A; Tucker, James K; Erberich, Joel M; Katariya, Rutvi; McDonald, Aidan H; Gallina, Iryna S; Tucker, Ariana L; Burgado, Jillybeth; Jaeger, Baptiste N; Barron, Jerika J; Pratt, Joshua M; Pena, Monique; Racha, Vipula; Lim, Christina K; Fernandes, Sarah; Benassi, Simone; Randolph-Moore, Lynne; Vadodaria, Krishna C; Marchetto, Maria C; Allen, Nicola J; Gage, Fred H

Omnidirectional 3D Printing of Anisotropic Nanofibrous Peptide Hydrogels

各向异性纳米纤维肽水凝胶的全方位3D打印

Farsheed, Adam C; Makhoul, Jonathan T; Chew-Martinez, Danielle; Maldonado, Eros; Liu, Justin; Yu, Le Tracy; Gorostieta-Salas, Elisa; Jones, Jeffrey R; Gage, Fred H; Hartgerink, Jeffrey D

Neuronal senescence may drive brain aging

神经元衰老可能是大脑老化的驱动因素。

Herdy, Joseph R; Mertens, Jerome; Gage, Fred H

Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies

恢复海马葡萄糖代谢可以改善阿尔茨海默病病理状态下的认知功能

Minhas, Paras S; Jones, Jeffrey R; Latif-Hernandez, Amira; Sugiura, Yuki; Durairaj, Aarooran S; Wang, Qian; Mhatre, Siddhita D; Uenaka, Takeshi; Crapser, Joshua; Conley, Travis; Ennerfelt, Hannah; Jung, Yoo Jin; Liu, Ling; Prasad, Praveena; Jenkins, Brenita C; Ay, Yeonglong Albert; Matrongolo, Matthew; Goodman, Ryan; Newmeyer, Traci; Heard, Kelly; Kang, Austin; Wilson, Edward N; Yang, Tao; Ullian, Erik M; Serrano, Geidy E; Beach, Thomas G; Wernig, Marius; Rabinowitz, Joshua D; Suematsu, Makoto; Longo, Frank M; McReynolds, Melanie R; Gage, Fred H; Andreasson, Katrin I