Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer
在非刺激条件下,Grb2 的缺失会抑制 PTEN,促进 Akt 诱导的肿瘤形成,并导致卵巢癌预后不良。
期刊:Oncogene
影响因子:7.3
doi:10.1038/onc.2015.279
Timsah, Z; Ahmed, Z; Ivan, C; Berrout, J; Gagea, M; Zhou, Y; Pena, G N A; Hu, X; Vallien, C; Kingsley, C V; Lu, Y; Hancock, J F; Liu, J; Gladden, A B; Mills, G B; Lopez-Berestein, G; Hung, M-C; Sood, A K; Bogdanov, M; Ladbury, J E