日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Homologous recombination-DNA damage response defects increase TMB and neoantigen load, but not effector T cell density and clonal diversity in pancreatic cancer

同源重组-DNA损伤反应缺陷会增加胰腺癌的肿瘤突变负荷(TMB)和新抗原负荷,但不会增加效应T细胞密度和克隆多样性。

Lei, Mengyue; Gai, Jessica; McPhaul, Thomas J; Luo, Huijuan; Lin, Penghui; Liu, Dongbing; Pishvaian, Michael; Roberts, Nicholas J; Wu, Kui; He, Jin; Zheng, Lei

Comparison of Shared Class I HLA-Bound Noncanonical Neoepitopes between Normal and Neoplastic Tissues of Pancreatic Adenocarcinoma.

胰腺腺癌正常组织和肿瘤组织中共享的 I 类 HLA 结合的非典型新表位的比较

Zhang Tengyi, Celiker Betul, Shao Yingkuan, Gai Jessica, Hill Mark, Wang Chunyu, Zheng Lei

Neoadjuvant radioimmunotherapy in pancreatic cancer enhances effector T cell infiltration and shortens their distances to tumor cells

胰腺癌新辅助放射免疫疗法可增强效应T细胞的浸润并缩短其与肿瘤细胞的距离。

Wang, Junke; Gai, Jessica; Zhang, Tengyi; Niu, Nan; Qi, Hanfei; Thomas, Dwayne L 2nd; Li, Keyu; Xia, Tao; Rodriguez, Christina; Parkinson, Rose; Durham, Jennifer; McPhaul, Thomas; Narang, Amol K; Anders, Robert A; Osipov, Arsen; Wang, Hao; He, Jin; Laheru, Daniel A; Herman, Joseph M; Lee, Valerie; Jaffee, Elizabeth M; Thompson, Elizabeth D; Zhu, Qingfeng; Zheng, Lei

A platform trial of neoadjuvant and adjuvant antitumor vaccination alone or in combination with PD-1 antagonist and CD137 agonist antibodies in patients with resectable pancreatic adenocarcinoma

一项针对可切除胰腺腺癌患者的新辅助和辅助抗肿瘤疫苗单药或联合PD-1拮抗剂和CD137激动剂抗体的平台试验

Heumann, Thatcher; Judkins, Carol; Li, Keyu; Lim, Su Jin; Hoare, Jessica; Parkinson, Rose; Cao, Haihui; Zhang, Tengyi; Gai, Jessica; Celiker, Betul; Zhu, Qingfeng; McPhaul, Thomas; Durham, Jennifer; Purtell, Katrina; Klein, Rachel; Laheru, Daniel; De Jesus-Acosta, Ana; Le, Dung T; Narang, Amol; Anders, Robert; Burkhart, Richard; Burns, William; Soares, Kevin; Wolfgang, Christopher; Thompson, Elizabeth; Jaffee, Elizabeth; Wang, Hao; He, Jin; Zheng, Lei

Genetic alterations in the neuronal development genes are associated with changes of the tumor immune microenvironment in pancreatic cancer

神经元发育基因的遗传改变与胰腺癌肿瘤免疫微环境的变化有关

Mu, Kaiyi; Fu, Juan; Gai, Jessica; Ravichandran, Harshitha; Zheng, Lei; Sun, Wei-Chih

Anti-IL-8 antibody activates myeloid cells and potentiates the anti-tumor activity of anti-PD-1 antibody in the humanized pancreatic cancer murine model

抗IL-8抗体可激活髓系细胞,并在人源化胰腺癌小鼠模型中增强抗PD-1抗体的抗肿瘤活性。

Li, Pan; Rozich, Noah; Wang, Jianxin; Wang, Junke; Xu, Yao; Herbst, Brian; Yu, Raymond; Muth, Stephen; Niu, Nan; Li, Keyu; Funes, Vanessa; Gai, Jessica; Osipov, Arsen; Edil, Barish H; Wolfgang, Christopher L; Lei, Ming; Liang, Tingbo; Zheng, Lei

Peritoneal and hematogenous metastases of ovarian cancer cells are both controlled by the p90RSK through a self-reinforcing cell autonomous mechanism

卵巢癌细胞的腹膜和血源性转移均由 p90RSK 通过自我强化的细胞自主机制控制

Erica Torchiaro, Annalisa Lorenzato, Martina Olivero, Donatella Valdembri, Paolo Armando Gagliardi, Marta Gai, Jessica Erriquez, Guido Serini, Maria Flavia Di Renzo