Gaia Colasante相关文献与解析，生知库 | 链接生命科学的每一步

Mattia Zaghi ，Federica Banfi ，Luca Massimino ，Monica Volpin ，Edoardo Bellini ，Simone Brusco ，Ivan Merelli ，Cristiana Barone ，Michela Bruni ，Linda Bossini ，Luigi Antonio Lamparelli ，Laura Pintado ，Deborah D'Aliberti ，Silvia Spinelli ，Luca Mologni ，Gaia Colasante ，Federica Ungaro ，Jean-Michel Cioni ，Emanuele Azzoni ，Rocco Piazza ，Eugenio Montini ，Vania Broccoli ，Alessandro Sessa

细胞生物学

SET

发表日期：2023

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Scn1a gene reactivation after symptom onset rescues pathological phenotypes in a mouse model of Dravet syndrome

在Dravet综合征小鼠模型中，症状出现后Scn1a基因的重新激活可挽救病理表型。

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-021-27837-w

Nicholas Valassina #,Simone Brusco #,Alessia Salamone,Linda Serra,Mirko Luoni,Serena Giannelli,Simone Bido,Luca Massimino,Federica Ungaro,Pietro Giuseppe Mazzara,Patrizia D'Adamo,Gabriele Lignani,Vania Broccoli,Gaia Colasante

Mouse

发表日期：2022

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Frataxin gene editing rescues Friedreich's ataxia pathology in dorsal root ganglia organoid-derived sensory neurons

Frataxin 基因编辑挽救了背根神经节类器官衍生的感觉神经元中的弗里德赖希共济失调病理

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-020-17954-3

Pietro Giuseppe Mazzara #, Sharon Muggeo #, Mirko Luoni, Luca Massimino, Mattia Zaghi, Parisa Tajalli-Tehrani Valverde, Simone Brusco, Matteo Jacopo Marzi, Cecilia Palma, Gaia Colasante, Angelo Iannielli, Marianna Paulis, Chiara Cordiglieri, Serena Gea Giannelli, Paola Podini, Cinzia Gellera, Franco

神经

发表日期：2020

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dCas9-Based Scn1a Gene Activation Restores Inhibitory Interneuron Excitability and Attenuates Seizures in Dravet Syndrome Mice

基于 dCas9 的 Scn1a 基因激活可恢复抑制性中间神经元兴奋性并减弱 Dravet 综合征小鼠的癫痫发作

期刊:Molecular Therapy

影响因子:12.1

doi:10.1016/j.ymthe.2019.08.018

Gaia Colasante, Gabriele Lignani, Simone Brusco, Claudia Di Berardino, Jenna Carpenter, Serena Giannelli, Nicholas Valassina, Simone Bido, Raffaele Ricci, Valerio Castoldi, Silvia Marenna, Timothy Church, Luca Massimino, Giuseppe Morabito, Fabio Benfenati, Stephanie Schorge, Letizia Leocani, Dimitri

In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy

体内实验表明，CRISPRa 可减少癫痫啮齿动物模型的癫痫发作并改善认知缺陷。

期刊:Brain

影响因子:10.6

doi:10.1093/brain/awaa045

Gaia Colasante ,Yichen Qiu ,Luca Massimino ,Claudia Di Berardino ,Jonathan H Cornford ,Albert Snowball ,Mikail Weston ,Steffan P Jones ,Serena Giannelli ,Andreas Lieb ,Stephanie Schorge ,Dimitri M Kullmann ,Vania Broccoli ,Gabriele Lignani

Reconstitution of the Human Nigro-striatal Pathway on-a-Chip Reveals OPA1-Dependent Mitochondrial Defects and Loss of Dopaminergic Synapses

芯片上重建人类黑质纹状体通路揭示了OPA1依赖性线粒体缺陷和多巴胺能突触丢失

期刊:Cell Reports

影响因子:7.5

doi:10.1016/j.celrep.2019.11.111

Angelo Iannielli ，Giovanni Stefano Ugolini ，Chiara Cordiglieri ，Simone Bido ，Alicia Rubio ，Gaia Colasante ，Marco Valtorta ，Tommaso Cabassi ，Marco Rasponi ，Vania Broccoli

Direct conversion of fibroblasts into functional astrocytes by defined transcription factors

通过特定的转录因子将成纤维细胞直接转化为功能性星形胶质细胞

期刊:Stem Cell Reports

影响因子:5.9

doi:10.1016/j.stemcr.2014.12.002

Massimiliano Caiazzo, Serena Giannelli, Pierluigi Valente, Gabriele Lignani, Annamaria Carissimo, Alessandro Sessa, Gaia Colasante, Rosa Bartolomeo, Luca Massimino, Stefano Ferroni, Carmine Settembre, Fabio Benfenati, Vania Broccoli

Remote control of induced dopaminergic neurons in parkinsonian rats

帕金森病大鼠诱导多巴胺能神经元的远程控制

期刊:Journal of Clinical Investigation

影响因子:13.3

doi:10.1172/JCI74664

Maria Teresa Dell'Anno, Massimiliano Caiazzo, Damiana Leo, Elena Dvoretskova, Lucian Medrihan, Gaia Colasante, Serena Giannelli, Ilda Theka, Giovanni Russo, Liudmila Mus, Gianni Pezzoli, Raul R Gainetdinov, Fabio Benfenati, Stefano Taverna, Alexander Dityatev, Vania Broccoli

Arx is a direct target of Dlx2 and thereby contributes to the tangential migration of GABAergic interneurons

Arx 是 Dlx2 的直接靶标，因此有助于 GABA 能中间神经元的切向迁移

期刊:Journal of Neuroscience

影响因子:4.4

doi:10.1523/JNEUROSCI.1283-08.2008

Gaia Colasante, Patrick Collombat, Valentina Raimondi, Dario Bonanomi, Carmelo Ferrai, Mario Maira, Kazuaki Yoshikawa, Ahmed Mansouri, Flavia Valtorta, John L R Rubenstein, Vania Broccoli

神经

发表日期：2008

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Temporal manipulation of the Scn1a gene reveals its essential role in adult brain function

Scn1a 基因的时间操控揭示了其在成人大脑功能中的重要作用

Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition

平衡的SET水平有利于细胞命运决定过程中正确的增强子库的形成。

Scn1a gene reactivation after symptom onset rescues pathological phenotypes in a mouse model of Dravet syndrome

在Dravet综合征小鼠模型中，症状出现后Scn1a基因的重新激活可挽救病理表型。

Frataxin gene editing rescues Friedreich's ataxia pathology in dorsal root ganglia organoid-derived sensory neurons

Frataxin 基因编辑挽救了背根神经节类器官衍生的感觉神经元中的弗里德赖希共济失调病理

dCas9-Based Scn1a Gene Activation Restores Inhibitory Interneuron Excitability and Attenuates Seizures in Dravet Syndrome Mice

基于 dCas9 的 Scn1a 基因激活可恢复抑制性中间神经元兴奋性并减弱 Dravet 综合征小鼠的癫痫发作

In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy

体内实验表明，CRISPRa 可减少癫痫啮齿动物模型的癫痫发作并改善认知缺陷。

Reconstitution of the Human Nigro-striatal Pathway on-a-Chip Reveals OPA1-Dependent Mitochondrial Defects and Loss of Dopaminergic Synapses

芯片上重建人类黑质纹状体通路揭示了OPA1依赖性线粒体缺陷和多巴胺能突触丢失

Direct conversion of fibroblasts into functional astrocytes by defined transcription factors

通过特定的转录因子将成纤维细胞直接转化为功能性星形胶质细胞

Remote control of induced dopaminergic neurons in parkinsonian rats

帕金森病大鼠诱导多巴胺能神经元的远程控制

Arx is a direct target of Dlx2 and thereby contributes to the tangential migration of GABAergic interneurons

Arx 是 Dlx2 的直接靶标，因此有助于 GABA 能中间神经元的切向迁移