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Extracellular caspase-1: a critical inducer and a therapeutic target of lung injury in gut ischemia-reperfusion

细胞外caspase-1：肠缺血再灌注损伤中肺损伤的关键诱导因子和治疗靶点

期刊:Frontiers in Immunology

影响因子:5.9

doi:10.3389/fimmu.2026.1811868

Ishikawa, Kouhei; Ma, Gaifeng; Jha, Alok; Murao, Atsushi; Wang, Ping; Aziz, Monowar

细胞生物学

发表日期：2026

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DLL4+ neutrophils promote Notch1-mediated endothelial PANoptosis to exacerbate acute lung injury in sepsis

DLL4+中性粒细胞促进Notch1介导的内皮细胞凋亡，从而加剧脓毒症中的急性肺损伤

期刊:Journal of Clinical Investigation

影响因子:13.3

doi:10.1172/JCI194310

Hui Jin ，Saoirse Holland ，Alok Jha ，Gaifeng Ma ，Jingsong Li ，Atsushi Murao ，Monowar Aziz ，Ping Wang

Lung Cancer Cell-intrinsic Asparagine Synthetase Potentiates Anti-Tumor Immunity via Modulating Immunogenicity and Facilitating Immune Remodeling in Metastatic Tumor-draining Lymph Nodes.

肺癌细胞固有天冬酰胺合成酶通过调节免疫原性和促进转移性肿瘤引流淋巴结的免疫重塑来增强抗肿瘤免疫力。

期刊:International Journal of Biological Sciences

影响因子:10

doi:10.7150/ijbs.114791

Zhang Ziyu, Du Nannan, He Gege, Zhang Mengting, Zhang Gaifeng, Gao Jie, Liu Ying, Deng Yuezhen, Sun Lunquan, Li Min

Polygonati Rhizoma Prevents Glucocorticoid-Induced Growth Inhibition of Muscle via Promoting Muscle Angiogenesis Through Deoxycholic Acid.

虎杖通过脱氧胆酸促进肌肉血管生成，从而防止糖皮质激素引起的肌肉生长抑制

期刊:Journal of Cachexia Sarcopenia and Muscle

影响因子:9.1

doi:10.1002/jcsm.13853

Shi Shiyi, Li Rui, Han Yanxu, Xie Jiahao, Wang Shaoshuai, Liu Jie, Wan Fangyan, Hou Gaifeng, Liu Zuhong, Sun Xiaobo, Zuo Bo, Jia Zhihao, Mei Zhinan, Song Tongxing

The role of an anti-inflammatory molecule AIM/CD5L in gut ischemia/reperfusion injury of male mice

抗炎分子AIM/CD5L在雄性小鼠肠道缺血/再灌注损伤中的作用

期刊:Molecular Medicine

影响因子:6

doi:10.1186/s10020-025-01385-1.

Russell Hollis ,Gaifeng Ma ,Alok Jha ,Megan Tenet ,Takayuki Kato ,Monowar Aziz # ,Ping Wang #

Radiation-induced eCIRP causes macrophage phagocytic dysfunction via mitochondrial impairment and ferroptosis

辐射诱导的eCIRP通过线粒体损伤和铁死亡导致巨噬细胞吞噬功能障碍。

期刊:Frontiers in Immunology

影响因子:5.7

doi:10.3389/fimmu.2025.1719613.

Mian Zhou ,Gaifeng Ma ,Jingsong Li ,Satoshi Yamaga ,Max Brenner ,Monowar Aziz # ,Ping Wang #

Identification of a multiple DAMP scavenger mimicking the DAMP-binding site of TLR4 to ameliorate lethal sepsis

鉴定一种能够模拟TLR4的DAMP结合位点的多重DAMP清除剂，以改善致命性脓毒症

期刊:Frontiers in Immunology

影响因子:5.7

doi:10.3389/fimmu.2025.1540908

Takuya Murao ,Gaifeng Ma ,Atsushi Murao ,Alok Jha ,Jingsong Li ,Yongchan Lee ,Mian Zhou ,Ping Wang # ,Monowar Aziz #

A novel molecule targeting neutrophil-mediated B-1a cell trogocytosis attenuates sepsis-induced acute lung injury

一种靶向中性粒细胞介导的B-1a细胞吞噬作用的新型分子可减轻脓毒症引起的急性肺损伤。

期刊:Frontiers in Immunology

影响因子:5.7

doi:10.3389/fimmu.2025.1597887

Yuichi Akama ，Jespar Chen ，Alok Jha ，Yongchan Lee ，Gaifeng Ma ，Jingsong Li ，Atsushi Murao ，Ping Wang # ，Monowar Aziz #

Small left ventricular size as a predictor for incident type 2 diabetes: insights from the UK biobank cardiovascular magnetic resonance substudy

左心室体积小是2型糖尿病发病率的预测因子：来自英国生物银行心血管磁共振子研究的启示

期刊:Diabetology & Metabolic Syndrome

影响因子:3.9

doi:10.1186/s13098-025-01939-7

Hu, Gaifeng; Peng, Xiaodong; He, Liu; Zhao, Zixu; Sang, Caihua; Dong, Jianzeng; Ma, Changsheng

A novel CD112-derived peptide targeting gut-primed neutrophils to attenuate deadly hepatic injury.

一种新型的 CD112 衍生肽，靶向肠道启动的中性粒细胞，以减轻致命的肝损伤。

Extracellular caspase-1: a critical inducer and a therapeutic target of lung injury in gut ischemia-reperfusion

细胞外caspase-1：肠缺血再灌注损伤中肺损伤的关键诱导因子和治疗靶点

DLL4+ neutrophils promote Notch1-mediated endothelial PANoptosis to exacerbate acute lung injury in sepsis

DLL4+中性粒细胞促进Notch1介导的内皮细胞凋亡，从而加剧脓毒症中的急性肺损伤

Lung Cancer Cell-intrinsic Asparagine Synthetase Potentiates Anti-Tumor Immunity via Modulating Immunogenicity and Facilitating Immune Remodeling in Metastatic Tumor-draining Lymph Nodes.

肺癌细胞固有天冬酰胺合成酶通过调节免疫原性和促进转移性肿瘤引流淋巴结的免疫重塑来增强抗肿瘤免疫力。

Polygonati Rhizoma Prevents Glucocorticoid-Induced Growth Inhibition of Muscle via Promoting Muscle Angiogenesis Through Deoxycholic Acid.

虎杖通过脱氧胆酸促进肌肉血管生成，从而防止糖皮质激素引起的肌肉生长抑制

The role of an anti-inflammatory molecule AIM/CD5L in gut ischemia/reperfusion injury of male mice

抗炎分子AIM/CD5L在雄性小鼠肠道缺血/再灌注损伤中的作用

Radiation-induced eCIRP causes macrophage phagocytic dysfunction via mitochondrial impairment and ferroptosis

辐射诱导的eCIRP通过线粒体损伤和铁死亡导致巨噬细胞吞噬功能障碍。

Identification of a multiple DAMP scavenger mimicking the DAMP-binding site of TLR4 to ameliorate lethal sepsis

鉴定一种能够模拟TLR4的DAMP结合位点的多重DAMP清除剂，以改善致命性脓毒症

A novel molecule targeting neutrophil-mediated B-1a cell trogocytosis attenuates sepsis-induced acute lung injury

一种靶向中性粒细胞介导的B-1a细胞吞噬作用的新型分子可减轻脓毒症引起的急性肺损伤。

Small left ventricular size as a predictor for incident type 2 diabetes: insights from the UK biobank cardiovascular magnetic resonance substudy

左心室体积小是2型糖尿病发病率的预测因子：来自英国生物银行心血管磁共振子研究的启示