日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Fragment-Based Drug Discovery of Novel High-affinity, Selective, and Anti-inflammatory Inhibitors of the Keap1-Nrf2 Protein-Protein Interaction

基于片段的新型高亲和力、选择性抗炎抑制剂在Keap1-Nrf2蛋白-蛋白相互作用中的应用

Lin, Chunyu; Narayanan, Dilip; Barreca, Marilia; Poulsen, Cecilie; da Costa, Leandro Silva; Chen, Xiangrong; Wichman, Kendall G; Charley, Cherisse A; Lindsay, Jaslin L; Dezfouli, Mahya; Vlissari, Dimitra; Mortensen, Thomas S; Chan, Camilla B; Wang, Jingyi; Richardson, William; Manning, Charlotte E; Chen, Zhuoyao; Zang, Jie; Käck, Helena; Gajhede, Michael; Bullock, Alex N; Blake, David J; Olagnier, David; Bach, Anders

Structural basis of THC analog activity at the Cannabinoid 1 receptor.

THC类似物在大麻素1受体上的活性结构基础

Thorsen Thor S, Kulkarni Yashraj, Sykes David A, Bøggild Andreas, Drace Taner, Hompluem Pattarin, Iliopoulos-Tsoutsouvas Christos, Nikas Spyros P, Daver Henrik, Makriyannis Alexandros, Nissen Poul, Gajhede Michael, Veprintsev Dmitry B, Boesen Thomas, Kastrup Jette S, Gloriam David E

The prototypical proton-coupled oligopeptide transporter YdgR from Escherichia coli facilitates chloramphenicol uptake into bacterial cells

来自大肠杆菌的典型质子偶联寡肽转运蛋白YdgR促进氯霉素进入细菌细胞。

Prabhala, Bala K; Aduri, Nanda G; Sharma, Neha; Shaheen, Aqsa; Sharma, Arpan; Iqbal, Mazhar; Hansen, Paul R; Brasen, Christoffer; Gajhede, Michael; Rahman, Moazur; Mirza, Osman

Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors

谷氨酸样GluD2受体正构位点配体结合的药理学和结构分析

Kristensen, Anders S; Hansen, Kasper B; Naur, Peter; Olsen, Lars; Kurtkaya, Natalie L; Dravid, Shashank M; Kvist, Trine; Yi, Feng; Pøhlsgaard, Jacob; Clausen, Rasmus P; Gajhede, Michael; Kastrup, Jette S; Traynelis, Stephen F

Structure and binding properties of a cameloid nanobody raised against KDM5B

针对KDM5B蛋白制备的骆驼纳米抗体的结构和结合特性

Wiuf, Anders; Kristensen, Line Hyltoft; Kristensen, Ole; Dorosz, Jerzy; Jensen, Jonas; Gajhede, Michael

Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site

一种新型N-甲基-D-天冬氨酸(NMDA)受体拮抗剂在GluN1甘氨酸结合位点的晶体结构和药理学特性

Kvist, Trine; Steffensen, Thomas Bielefeldt; Greenwood, Jeremy R; Mehrzad Tabrizi, Fatemeh; Hansen, Kasper B; Gajhede, Michael; Pickering, Darryl S; Traynelis, Stephen F; Kastrup, Jette Sandholm; Bräuner-Osborne, Hans

The structure of amylosucrase from Deinococcus radiodurans has an unusual open active-site topology

来自耐辐射球菌的淀粉蔗糖酶的结构具有不寻常的开放活性位点拓扑结构

Skov, Lars K; Pizzut-Serin, Sandra; Remaud-Simeon, Magali; Ernst, Heidi A; Gajhede, Michael; Mirza, Osman

Structure of the first PDZ domain of human PSD-93

人类PSD-93第一个PDZ结构域的结构

Fiorentini, Monica; Nielsen, Ann Kallehauge; Kristensen, Ole; Kastrup, Jette S; Gajhede, Michael

Structure of a SARS coronavirus-derived peptide bound to the human major histocompatibility complex class I molecule HLA-B*1501

SARS冠状病毒衍生肽与人类主要组织相容性复合体I类分子HLA-B*1501结合的结构

Røder, Gustav; Kristensen, Ole; Kastrup, Jette S; Buus, Søren; Gajhede, Michael

A helical structural nucleus is the primary elongating unit of insulin amyloid fibrils

螺旋结构核是胰岛素淀粉样原纤维的主要延伸单元。

Vestergaard, Bente; Groenning, Minna; Roessle, Manfred; Kastrup, Jette S; van de Weert, Marco; Flink, James M; Frokjaer, Sven; Gajhede, Michael; Svergun, Dmitri I