Gal Bitan相关文献与解析，生知库 | 链接生命科学的每一步

Lynda E Polgreen, Agnes H Chen, Youngju Pak, Anna Luzzi, Adolfo Morales Garval, Jonathan Acevedo, Gal Bitan, Michelina Iacovino, Cara O'Neill, Julie B Eisengart

信号转导

发表日期：2024

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Biomarkers for parkinsonian disorders in CNS-originating EVs: promise and challenges

中枢神经系统来源的 EVs 中帕金森病的生物标志物：前景与挑战

期刊:Acta Neuropathologica

影响因子:9.3

doi:10.1007/s00401-023-02557-1

Suman Dutta, Simon Hornung, Hash Brown Taha, Gal Bitan

Development of a Novel Electrochemiluminescence ELISA for Quantification of α-Synuclein Phosphorylated at Ser129 in Biological Samples

开发一种新型电化学发光 ELISA 方法，用于定量测定生物样品中 Ser129 位点磷酸化的 α-突触核蛋白

期刊:ACS Chemical Neuroscience

影响因子:4.1

doi:10.1021/acschemneuro.2c00676

Suman Dutta, Simon Hornung, Hash Brown Taha, Karl Biggs, Ibrar Siddique, Lea M Chamoun, Hedieh Shahpasand-Kroner, Carter Lantz, Marcos Herrera-Vaquero, Nadia Stefanova, Joseph A Loo, Gal Bitan

Three-repeat and four-repeat tau isoforms form different oligomers

三次和四次重复的 tau 亚型形成不同的低聚物

期刊:Protein Science

影响因子:4.5

doi:10.1002/pro.4257

Hedieh Shahpasand-Kroner, Jennifer Portillo, Carter Lantz, Paul M Seidler, Natalie Sarafian, Joseph A Loo, Gal Bitan

信号转导

发表日期：2022

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The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice

分子钳 CLR01 可改善 P301S-tau 转基因小鼠的行为缺陷并减少 tau 病理

期刊:Alzheimers Research & Therapy

影响因子:7.9

doi:10.1186/s13195-020-00743-x

Jing Di #, Ibrar Siddique #, Zizheng Li, Ghattas Malki, Simon Hornung, Suman Dutta, Ian Hurst, Ella Ishaaya, Austin Wang, Sally Tu, Ani Boghos, Ida Ericsson, Frank-Gerrit Klärner, Thomas Schrader, Gal Bitan

Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes

赖氨酸选择性分子镊子可渗透细胞并集中在溶酶体中

期刊:Communications Biology

影响因子:5.2

doi:10.1038/s42003-021-02603-2

Zizheng Li, Ibrar Siddique, Inesa Hadrović, Abbna Kirupakaran, Jiwen Li, Ye Zhang, Frank-Gerrit Klärner, Thomas Schrader, Gal Bitan

The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease

淀粉样蛋白抑制剂 CLR01 可缓解自噬并改善严重溶酶体贮积症中的神经病理学

期刊:Molecular Therapy

影响因子:12.1

doi:10.1016/j.ymthe.2020.02.005

Antonio Monaco, Veronica Maffia, Nicolina Cristina Sorrentino, Irene Sambri, Yulia Ezhova, Teresa Giuliano, Vincenzo Cacace, Edoardo Nusco, Maria De Risi, Elvira De Leonibus, Thomas Schrader, Frank-Gerrit Klärner, Gal Bitan, Alessandro Fraldi

CNS-Derived Blood Exosomes as a Promising Source of Biomarkers: Opportunities and Challenges

中枢神经系统来源的血液外泌体作为生物标志物的有希望的来源：机遇与挑战

期刊:Frontiers in Molecular Neuroscience

影响因子:3.5

doi:10.3389/fnmol.2020.00038

Simon Hornung, Suman Dutta, Gal Bitan

神经

发表日期：2020

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Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation

淀粉样β蛋白寡聚体促进tau纤维种子的吸收，增强细胞内tau聚集

期刊:Alzheimers Research & Therapy

影响因子:7.9

doi:10.1186/s13195-019-0541-9

Woo Shik Shin, Jing Di, Qin Cao, Binsen Li, Paul M Seidler, Kevin A Murray, Gal Bitan, Lin Jiang

Ischemic axonal injury up-regulates MARK4 in cortical neurons and primes tau phosphorylation and aggregation

缺血性轴突损伤上调皮质神经元中的 MARK4，并引发 tau 磷酸化和聚集

期刊:Acta Neuropathologica Communications

影响因子:6.2

doi:10.1186/s40478-019-0783-6

Eric Y Hayden, Jennifer Putman, Stefanie Nunez, Woo Shik Shin, Mandavi Oberoi, Malena Charreton, Suman Dutta, Zizheng Li, Yutaro Komuro, Mary Teena Joy, Gal Bitan, Allan MacKenzie-Graham, Lin Jiang, Jason D Hinman

Anakinra in Sanfilippo syndrome: a phase 1/2 trial

阿纳白滞素在 Sanfilippo 综合征中的应用：一项 1/2 期临床试验

Biomarkers for parkinsonian disorders in CNS-originating EVs: promise and challenges

中枢神经系统来源的 EVs 中帕金森病的生物标志物：前景与挑战

Development of a Novel Electrochemiluminescence ELISA for Quantification of α-Synuclein Phosphorylated at Ser129 in Biological Samples

开发一种新型电化学发光 ELISA 方法，用于定量测定生物样品中 Ser129 位点磷酸化的 α-突触核蛋白

Three-repeat and four-repeat tau isoforms form different oligomers

三次和四次重复的 tau 亚型形成不同的低聚物

The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice

分子钳 CLR01 可改善 P301S-tau 转基因小鼠的行为缺陷并减少 tau 病理

Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes

赖氨酸选择性分子镊子可渗透细胞并集中在溶酶体中

The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease

淀粉样蛋白抑制剂 CLR01 可缓解自噬并改善严重溶酶体贮积症中的神经病理学

CNS-Derived Blood Exosomes as a Promising Source of Biomarkers: Opportunities and Challenges

中枢神经系统来源的血液外泌体作为生物标志物的有希望的来源：机遇与挑战

Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation

淀粉样β蛋白寡聚体促进tau纤维种子的吸收，增强细胞内tau聚集

Ischemic axonal injury up-regulates MARK4 in cortical neurons and primes tau phosphorylation and aggregation

缺血性轴突损伤上调皮质神经元中的 MARK4，并引发 tau 磷酸化和聚集