The phosphoinositide 3-kinase inhibitor alpelisib restores actin organization and improves proximal tubule dysfunction in vitro and in a mouse model of Lowe syndrome and Dent disease
磷脂酰肌醇3-激酶抑制剂alpelisib可在体外以及Lowe综合征和Dent病的鼠模型中恢复肌动蛋白组织并改善近端肾小管功能障碍。
期刊:Kidney International
影响因子:12.6
doi:10.1016/j.kint.2020.05.040
Berquez, Marine; Gadsby, Jonathan R; Festa, Beatrice Paola; Butler, Richard; Jackson, Stephen P; Berno, Valeria; Luciani, Alessandro; Devuyst, Olivier; Gallop, Jennifer L
