日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Inference of germinal center evolutionary dynamics via simulation-based deep learning

基于模拟的深度学习推断胚胎中心演化动力学

Ralph, Duncan K; Bakis, Athanasios G; Galloway, Jared G; Vora, Ashni A; Araki, Tatsuya; Victora, Gabriel D; Song, Yun S; DeWitt, William S; Matsen, Frederick A

Clonal interference and changing selective pressures shape the escape of SARS-CoV-2 from hundreds of antibodies

克隆干扰和不断变化的选择压力影响着SARS-CoV-2病毒逃避数百种抗体的能力

Haddox, Hugh K; Abdel Aziz, Omar; Galloway, Jared G; Kent, Javen; Cooper, Cameron R; Jennings-Shaffer, Chris; Dumm, Will; Temple, Seth D; Bloom, Jesse D; Matsen, Frederick A 4th

The mutation rate of SARS-CoV-2 is highly variable between sites and is influenced by sequence context, genomic region, and RNA structure

SARS-CoV-2的突变率在不同位点之间差异很大,并受序列环境、基因组区域和RNA结构的影响。

Haddox, Hugh K; Angehrn, Georg; Sesta, Luca; Jennings-Shaffer, Chris; Temple, Seth D; Galloway, Jared G; Hinrichs, Angie S; DeWitt, William S; Bloom, Jesse D; Iv, Frederick A Matsen; Neher, Richard A

The mutation rate of SARS-CoV-2 is highly variable between sites and is influenced by sequence context, genomic region, and RNA structure

SARS-CoV-2的突变率在不同位点之间差异很大,并受序列环境、基因组区域和RNA结构的影响。

Haddox, Hugh K; Angehrn, Georg; Sesta, Luca; Jennings-Shaffer, Chris; Temple, Seth D; Galloway, Jared G; DeWitt, William S; Bloom, Jesse D; Matsen, Frederick A 4th; Neher, Richard A

Replaying germinal center evolution on a quantified affinity landscape.

在量化的亲和力景观上重现胚胎中心演化

DeWitt William S, Vora Ashni A, Araki Tatsuya, Galloway Jared G, Alkutkar Tanwee, Bortolatto Juliana, Castro Tiago B R, Dumm Will, Jennings-Shaffer Chris, Jia Tongqiu, Mesin Luka, Ozorowski Gabriel, Pae Juhee, Ralph Duncan K, Bloom Jesse D, Nourmohammad Armita, Song Yun S, Ward Andrew B, Starr Tyler N, Matsen Frederick A 4th, Victora Gabriel D

Deep mutational scanning reveals functional constraints and antibody-escape potential of Lassa virus glycoprotein complex.

深度突变扫描揭示了拉沙病毒糖蛋白复合物的功能限制和抗体逃逸潜力

Carr Caleb R, Crawford Katharine H D, Murphy Michael, Galloway Jared G, Haddox Hugh K, Matsen Frederick A 4th, Andersen Kristian G, King Neil P, Bloom Jesse D

Deep mutational scanning of CYP2C19 in human cells reveals a substrate specificity-abundance tradeoff.

对人类细胞中 CYP2C19 的深度突变扫描揭示了底物特异性与丰度之间的权衡关系

Boyle Gabriel E, Sitko Katherine A, Galloway Jared G, Haddox Hugh K, Bianchi Aisha Haley, Dixon Ajeya, Wheelock Melinda K, Vandi Allyssa J, Wang Ziyu R, Thomson Raine E S, Garge Riddhiman K, Rettie Allan E, Rubin Alan F, Geck Renee C, Gillam Elizabeth M J, DeWitt William S, Matsen Frederick A 4th, Fowler Douglas M

Automatic Differentiation is no Panacea for Phylogenetic Gradient Computation

自动微分并非系统发育梯度计算的万能药

Fourment, Mathieu; Swanepoel, Christiaan J; Galloway, Jared G; Ji, Xiang; Gangavarapu, Karthik; Suchard, Marc A; Matsen Iv, Frederick A

Efficient ancestry and mutation simulation with msprime 1.0

使用 msprime 1.0 进行高效的祖先和突变模拟

Baumdicker, Franz; Bisschop, Gertjan; Goldstein, Daniel; Gower, Graham; Ragsdale, Aaron P; Tsambos, Georgia; Zhu, Sha; Eldon, Bjarki; Ellerman, E Castedo; Galloway, Jared G; Gladstein, Ariella L; Gorjanc, Gregor; Guo, Bing; Jeffery, Ben; Kretzschumar, Warren W; Lohse, Konrad; Matschiner, Michael; Nelson, Dominic; Pope, Nathaniel S; Quinto-Cortés, Consuelo D; Rodrigues, Murillo F; Saunack, Kumar; Sellinger, Thibaut; Thornton, Kevin; van Kemenade, Hugo; Wohns, Anthony W; Wong, Yan; Gravel, Simon; Kern, Andrew D; Koskela, Jere; Ralph, Peter L; Kelleher, Jerome

A community-maintained standard library of population genetic models

社区维护的群体遗传模型标准库

Adrion, Jeffrey R; Cole, Christopher B; Dukler, Noah; Galloway, Jared G; Gladstein, Ariella L; Gower, Graham; Kyriazis, Christopher C; Ragsdale, Aaron P; Tsambos, Georgia; Baumdicker, Franz; Carlson, Jedidiah; Cartwright, Reed A; Durvasula, Arun; Gronau, Ilan; Kim, Bernard Y; McKenzie, Patrick; Messer, Philipp W; Noskova, Ekaterina; Ortega-Del Vecchyo, Diego; Racimo, Fernando; Struck, Travis J; Gravel, Simon; Gutenkunst, Ryan N; Lohmueller, Kirk E; Ralph, Peter L; Schrider, Daniel R; Siepel, Adam; Kelleher, Jerome; Kern, Andrew D