日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Model-based assessment of VRC07-523LS dosing in infants through population pharmacokinetic -pharmacodynamic modelling in adults and infants

基于模型的VRC07-523LS在婴儿中的给药评估:通过成人和婴儿的群体药代动力学-药效学模型

Huynh, Dustin; Nikanjam, Mina; Cunningham, Coleen K; McFarland, Elizabeth J; Muresan, Petronella; Perlowski, Charlotte; Yin, Dwight E; Moye, Jack; Spiegel, Hans; Gama, Lucio; Gaudinski, Martin; Capparelli, Edmund V

Enhanced Clearance of HIV-1 Broadly Neutralizing Antibody VRC07-523-LS During Viremia: Influences on Trial Design and Analysis

病毒血症期间HIV-1广谱中和抗体VRC07-523-LS清除率的提高:对试验设计和分析的影响

Smith, Nicholas M; Ho, Brian M; Bar, Katharine J; Gama, Lucio; Dziubla, Gabrielle; Koup, Richard A; Pensiero, Michael; Serebryannyy, Leonid; Caskey, Marina; Wilkin, Timothy J; Wood, Troy D; Morse, Gene D; Venuto, Charles S; Cha, Ray; Ma, Qing

Broadly neutralizing antibodies, nonneutralizing antibodies and broadly effector antibodies to prevent HIV transmission?

广谱中和抗体、非中和抗体和广谱效应抗体能否预防 HIV 传播?

Van de Perre, Philippe; Moore, Penny L; Nagot, Nicolas; Gama, Lucio; Moles, Jean-Pierre

Pharmacokinetic interaction assessment of an HIV broadly neutralizing monoclonal antibody VRC07-523LS: a cross-protocol analysis of three phase 1 trials in people without HIV

对一种广谱中和HIV的单克隆抗体VRC07-523LS进行药代动力学相互作用评估:一项纳入三项I期临床试验的非HIV感染者交叉方案分析

Chawana, Tariro D; Walsh, Stephen R; Stranix-Chibanda, Lynda; Chirenje, Zvavahera M; Yu, Chenchen; Zhang, Lily; Seaton, Kelly E; Heptinstall, Jack; Zhang, Lu; Paez, Carmen A; Gamble, Theresa; Karuna, Shelly T; Andrew, Philip; Hanscom, Brett; Sobieszczyk, Magdalena E; Edupuganti, Srilatha; Gay, Cynthia L; Mannheimer, Sharon B; Hurt, Christopher B; Stephenson, Kathryn E; Polakowski, Laura L; Spiegel, Hans; Yacovone, Margaret; Regenold, Stephanie; Yen, Catherine; Baumblatt, Jane Ag; Gama, Lucio; Barouch, Dan H; Piwowar-Manning, Estelle; Koup, Richard A; Tomaras, Georgia D; Hyrien, Ollivier; Roxby, Alison C; Huang, Yunda

Analytical treatment interruption among women with HIV in southern Africa who received VRC01 or placebo in the Antibody Mediated Prevention Study: ATI stakeholder engagement, implementation and early clinical data

在抗体介导预防研究中,接受VRC01或安慰剂治疗的南部非洲HIV感染女性的分析性治疗中断:ATI利益相关者参与、实施和早期临床数据

Karuna, Shelly; Laher, Fatima; Dadabhai, Sufia; Yu, Pei-Chun; Grove, Doug; Orrell, Catherine; Makhema, Joseph; Hosseinipour, Mina C; Mathew, Carrie-Anne; Brumskine, William; Mgodi, Nyaradzo; Andrew, Philip; Gama, Lucio; Karg, Carissa; Broder, Gail; Baepanye, Kagisho; Lucas, Jonathan; Andrasik, Michele; Takuva, Simbarashe; Villaran, Manuel; Takalani, Azwidihwi; Tressler, Randall; Soto-Torres, Lydia; Woodward Davis, Amanda S; Dhai, Ames; Sanne, Ian M; Cohen, Myron S; Corey, Lawrence; Gray, Glenda; deCamp, Allan C; Bar, Katharine J

Safety, tolerability, pharmacokinetics, and neutralisation activities of the anti-HIV-1 monoclonal antibody PGT121.414.LS administered alone and in combination with VRC07-523LS in adults without HIV in the USA (HVTN 136/HPTN 092): a first-in-human, open-label, randomised controlled phase 1 trial

在美国,一项首次人体试验(HVTN 136/HPTN 092)研究了抗HIV-1单克隆抗体PGT121.414.LS单独使用以及与VRC07-523LS联合使用时,在美国未感染HIV的成年人中的安全性、耐受性、药代动力学和中和活性。该研究为一项开放标签、随机对照的I期临床试验。

Edupuganti, Srilatha; Hurt, Christopher B; Stephenson, Kathryn E; Huang, Yunda; Paez, Carmen A; Yu, Chenchen; Yen, Catherine; Hanscom, Brett; He, Zonglin; Miner, Maurine D; Gamble, Theresa; Heptinstall, Jack; Seaton, Kelly E; Domin, Elizabeth; Lin, Bob C; McKee, Krisha; Doria-Rose, Nicole; Regenold, Stephanie; Spiegel, Hans; Anderson, Maija; McClosky, Nadia; Zhang, Lily; Piwowar-Manning, Estelle; Ackerman, Margaret E; Pensiero, Michael; Dye, Bonnie J; Landovitz, Raphael J; Mayer, Kenneth; Siegel, Marc; Sobieszczyk, Magdalena; Walsh, Stephen R; Gama, Lucio; Barouch, Dan H; Montefiori, David C; Tomaras, Georgia D

Safety, Tolerability, and Pharmacokinetics of Long-Acting Broadly Neutralizing HIV-1 Monoclonal Antibody VRC07-523LS in Newborn Infants Exposed to HIV-1

长效广谱中和 HIV-1 单克隆抗体 VRC07-523LS 在暴露于 HIV-1 的新生儿中的安全性、耐受性和药代动力学

Cunningham, Coleen K; McFarland, Elizabeth J; Muresan, Petronella; Capparelli, Edmund V; Perlowski, Charlotte; Johnston, Benjamin; Bone, Frederic; Purdue, Lynette; Yin, Dwight E; Moye, Jack; Spiegel, Hans M L; Majji, Sai; Theron, Gerhard B; Mujuru, Hilda A; Purswani, Murli; Alvarez, Grace; Deville, Jaime G; Chambers, Carrie; Brown, Emily; Harding, Paul A; Tobin, Nicole H; Low, Kwang; Gama, Lucio

Safety and antiviral effect of a triple combination of HIV-1 broadly neutralizing antibodies: a phase 1/2a trial

三种HIV-1广谱中和抗体组合的安全性和抗病毒效果:一项1/2a期试验

Julg, Boris; Walker-Sperling, Victoria E K; Wagh, Kshitij; Aid, Malika; Stephenson, Kathryn E; Zash, Rebecca; Liu, Jinyan; Nkolola, Joseph P; Hoyt, Amelia; Castro, Mike; Serebryannyy, Leonid; Yanosick, Katherine; Speidel, Tessa; Borducchi, Erica N; Murzda, Tetyana; Maxfield, Lori; Arduino, Roberto; McDermott, Adrian B; Gama, Lucio; Giorgi, Elena E; Koup, Richard A; Seaman, Michael S; Rolle, Charlotte-Paige; DeJesus, Edwin; Li, Wenjun; Korber, Bette; Barouch, Dan H

Safety and pharmacokinetics of VRC07-523LS administered via different routes and doses (HVTN 127/HPTN 087): A Phase I randomized clinical trial

VRC07-523LS 不同给药途径和剂量(HVTN 127/HPTN 087)的安全性和药代动力学:一项 I 期随机临床试验

Walsh, Stephen R; Gay, Cynthia L; Karuna, Shelly T; Hyrien, Ollivier; Skalland, Timothy; Mayer, Kenneth H; Sobieszczyk, Magdalena E; Baden, Lindsey R; Goepfert, Paul A; Del Rio, Carlos; Pantaleo, Guiseppe; Andrew, Philip; Karg, Carissa; He, Zonglin; Lu, Huiyin; Paez, Carmen A; Baumblatt, Jane A G; Polakowski, Laura L; Chege, Wairimu; Anderson, Maija A; Janto, Sophie; Han, Xue; Huang, Yunda; Dumond, Julie; Ackerman, Margaret E; McDermott, Adrian B; Flach, Britta; Piwowar-Manning, Estelle; Seaton, Kelly; Tomaras, Georgia D; Montefiori, David C; Gama, Lucio; Mascola, John R

Impact of LS Mutation on Pharmacokinetics of Preventive HIV Broadly Neutralizing Monoclonal Antibodies: A Cross-Protocol Analysis of 16 Clinical Trials in People without HIV

LS突变对预防性HIV广谱中和单克隆抗体药代动力学的影响:一项纳入16项非HIV感染者临床试验的跨方案分析

Mayer, Bryan T; Zhang, Lily; deCamp, Allan C; Yu, Chenchen; Sato, Alicia; Angier, Heather; Seaton, Kelly E; Yates, Nicole; Ledgerwood, Julie E; Mayer, Kenneth; Caskey, Marina; Nussenzweig, Michel; Stephenson, Kathryn; Julg, Boris; Barouch, Dan H; Sobieszczyk, Magdalena E; Edupuganti, Srilatha; Kelley, Colleen F; McElrath, M Juliana; Gelderblom, Huub C; Pensiero, Michael; McDermott, Adrian; Gama, Lucio; Koup, Richard A; Gilbert, Peter B; Cohen, Myron S; Corey, Lawrence; Hyrien, Ollivier; Tomaras, Georgia D; Huang, Yunda