日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Dietary caffeine to assess CYP1A2 activity, tailor clozapine doses, and predict treatment response: genetic, epigenetic and clinical analyses

利用膳食咖啡因评估 CYP1A2 活性、调整氯氮平剂量和预测治疗反应:遗传学、表观遗传学和临床分析

Laaboub, Nermine; Vandenberghe, Frederik; Ansermot, Nicolas; Piras, Marianna; Ranjbar, Setareh; Petrovic, Dusan; Pistis, Giorgio; Vandenberghe-Dürr, Sophie; Strippoli, Marie-Pierre F; Marques-Vidal, Pedro; Ponte, Belen; Pruijm, Menno; Vogt, Bruno; Gamma, Franziska; von Gunten, Armin; Plessen, Kerstin Jessica; Conus, Philippe; Crettol, Séverine; Vollenweider, Peter; Preisig, Martin; Bochud, Murielle; Eap, Chin B

Influence of CYP2D6 Genotypes and Phenotypes on the Plasma Levels and Clinical Response to Aripiprazole

CYP2D6基因型和表型对阿立哌唑血浆浓度和临床疗效的影响

Gras, Cécile; Piras, Marianna; Ranjbar, Setareh; Grosu, Claire; Girardin, François R; Vandenberghe, Frederik; Ansermot, Nicolas; Grandjean, Carole; Kaiser, Stefan; Gamma, Franziska; Plessen, Kerstin Jessica; von Gunten, Armin; Conus, Philippe; Crettol, Séverine; Eap, Chin B

Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment.

UM171 的结构模拟和新生癌症突变体利用 E3 连接酶 KBTBD4 募集 HDAC1/2

Chen Zhuoyao, Chi Gamma, Balo Timea, Chen Xiangrong, Montes Beatriz Ralsi, Clifford Steven C, D'Angiolella Vincenzo, Szabo Timea, Kiss Arpad, Novak Tibor, Herner András, Kotschy András, Bullock Alex N

Metabolic mapping of the human solute carrier superfamily.

人类溶质载体超家族的代谢图谱

Wiedmer Tabea, Teoh Shao Thing, Christodoulaki Eirini, Wolf Gernot, Tian Chengzhe, Sedlyarov Vitaly, Jarret Abigail, Leippe Philipp, Frommelt Fabian, Ingles-Prieto Alvaro, Lindinger Sabrina, Barbosa Barbara M G, Onstein Svenja, Klimek Christoph, Garcia Julio, Serrano Iciar, Reil Daniela, Santacruz Diana, Piotrowski Mary, Noell Stephen, Bueschl Christoph, Li Huanyu, Chi Gamma, Mereiter Stefan, Oliveira Tiago, Penninger Josef M, Sauer David B, Steppan Claire M, Viollet Coralie, Klavins Kristaps, Hannich J Thomas, Goldmann Ulrich, Superti-Furga Giulio

Zelenirstat Inhibits N-Myristoyltransferases to Disrupt Src Family Kinase Signaling and Oxidative Phosphorylation, Killing Acute Myeloid Leukemia Cells

Zelenirstat通过抑制N-肉豆蔻酰转移酶来破坏Src家族激酶信号传导和氧化磷酸化,从而杀死急性髓系白血病细胞。

Jay M Gamma ,Qiang Liu ,Erwan Beauchamp ,Aishwarya Iyer ,Megan C Yap ,Zoulika Zak ,Cassidy Ekstrom ,Rony Pain ,Morris A Kostiuk ,John R Mackey ,Joseph Brandwein ,Jean C Y Wang ,Luc G Berthiaume

Psychosocial and context factors associated with breastfeeding and complementary feeding changes in Belize: a mixed methods approach

伯利兹母乳喂养和辅食添加变化相关的心理社会因素和环境因素:一种混合方法研究

Slekiene, Jurgita; Gamma, Anna Elisabeth; Wade, Paulette; Robateau, Denise; Oketch, Jecinter Akinyi; Palacios, Silvie

Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2

SIT1脯氨酸转运蛋白与COVID-19受体ACE2复合物的结构和功能

Li, Huanyu Z; Pike, Ashley C W; Lotsaris, Irina; Chi, Gamma; Hansen, Jesper S; Lee, Sarah C; Rödström, Karin E J; Bushell, Simon R; Speedman, David; Evans, Adam; Wang, Dong; He, Didi; Shrestha, Leela; Nasrallah, Chady; Burgess-Brown, Nicola A; Vandenberg, Robert J; Dafforn, Timothy R; Carpenter, Elisabeth P; Sauer, David B

The binding and mechanism of a positive allosteric modulator of Kv3 channels

Kv3通道正变构调节剂的结合及机制

Qiansheng Liang #, Gamma Chi #, Leonardo Cirqueira, Lianteng Zhi, Agostino Marasco, Nadia Pilati, Martin J Gunthorpe, Giuseppe Alvaro, Charles H Large, David B Sauer, Werner Treptow, Manuel Covarrubias

Multiomics analysis identifies oxidative phosphorylation as a cancer vulnerability arising from myristoylation inhibition

多组学分析发现,肉豆蔻酰化抑制导致的氧化磷酸化是癌症的一种脆弱性因素。

Erwan Beauchamp,Jay M Gamma,Christopher R Cromwell,Eman W Moussa,Rony Pain,Morris A Kostiuk,Claudia Acevedo-Morantes,Aishwarya Iyer,Megan Yap,Krista M Vincent,Lynne M Postovit,Olivier Julien,Basil P Hubbard,John R Mackey,Luc G Berthiaume

Structural basis for inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonist

小分子拮抗剂抑制溶酶体双孔通道TPC2的结构基础

Gamma Chi, Dawid Jaślan, Veronika Kudrina, Julia Böck, Huanyu Li, Ashley C W Pike, Susanne Rautenberg, Einar Krogsaeter, Tina Bohstedt, Dong Wang, Gavin McKinley, Alejandra Fernandez-Cid, Shubhashish M M Mukhopadhyay, Nicola A Burgess-Brown, Marco Keller, Franz Bracher, Christian Grimm, Katharina L