日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Hedgehog controls hepatic stellate cell fate by regulating metabolism

Hedgehog通过调节代谢来控制肝星状细胞的命运

Yuping Chen, Steve S Choi, Gregory A Michelotti, Isaac S Chan, Marzena Swiderska-Syn, Gamze F Karaca, Guanhua Xie, Cynthia A Moylan, Francesca Garibaldi, Richard Premont, Hagir B Suliman, Claude A Piantadosi, Anna Mae Diehl

NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease

NKT 相关的刺猬因子和骨桥蛋白促进非酒精性脂肪肝中的纤维化

Wing-Kin Syn, Kolade M Agboola, Marzena Swiderska, Gregory A Michelotti, Evaggelia Liaskou, Herbert Pang, Guanhua Xie, George Philips, Isaac S Chan, Gamze F Karaca, Thiago de Almeida Pereira, Yuping Chen, Zhiyong Mi, Paul C Kuo, Steve S Choi, Cynthia D Guy, Manal F Abdelmalek, Anna Mae Diehl

Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis

骨桥蛋白由 Hedgehog 信号通路激活诱导产生,并促进非酒精性脂肪性肝炎的纤维化进展。

Syn, Wing-Kin; Choi, Steve S; Liaskou, Evaggelia; Karaca, Gamze F; Agboola, Kolade M; Oo, Ye Htun; Mi, Zhiyong; Pereira, Thiago A; Zdanowicz, Marzena; Malladi, Padmini; Chen, Yuping; Moylan, Cynthia; Jung, Youngmi; Bhattacharya, Syamal D; Teaberry, Vanessa; Omenetti, Alessia; Abdelmalek, Manal F; Guy, Cynthia D; Adams, David H; Kuo, Paul C; Michelotti, Gregory A; Whitington, Peter F; Diehl, Anna Mae

Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer

Hedgehog 信号拮抗剂促进小鼠原发性肝癌模型中肝纤维化和肝细胞癌的消退

George M Philips, Isaac S Chan, Marzena Swiderska, Vanessa T Schroder, Cynthia Guy, Gamze F Karaca, Cynthia Moylan, Talaignair Venkatraman, Sebastian Feuerlein, Wing-Kin Syn, Youngmi Jung, Rafal P Witek, Steve Choi, Gregory A Michelotti, Fatima Rangwala, Elmar Merkle, Christopher Lascola, Anna Mae D

Activation of Rac1 promotes hedgehog-mediated acquisition of the myofibroblastic phenotype in rat and human hepatic stellate cells

Rac1的激活促进大鼠和人肝星状细胞中hedgehog信号通路介导的肌成纤维细胞表型的获得

Choi, Steve S; Witek, Rafal P; Yang, Liu; Omenetti, Alessia; Syn, Wing-Kin; Moylan, Cynthia A; Jung, Youngmi; Karaca, Gamze F; Teaberry, Vanessa S; Pereira, Thiago A; Wang, Jiangbo; Ren, Xiu-Rong; Diehl, Anna Mae

Hedgehog signaling is critical for normal liver regeneration after partial hepatectomy in mice

Hedgehog信号通路对于小鼠部分肝切除术后正常的肝脏再生至关重要。

Ochoa, Begoña; Syn, Wing-Kin; Delgado, Igotz; Karaca, Gamze F; Jung, Youngmi; Wang, Jiangbo; Zubiaga, Ana M; Fresnedo, Olatz; Omenetti, Alessia; Zdanowicz, Marzena; Choi, Steve S; Diehl, Anna Mae

Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease

进行性非酒精性脂肪肝疾病中自然杀伤T细胞的积累

Wing-Kin Syn ,Ye Htun Oo, Thiago A Pereira, Gamze F Karaca, Youngmi Jung, Alessia Omenetti, Rafal P Witek, Steve S Choi, Cynthia D Guy, Caitlin M Fearing, Vanessa Teaberry, Fausto E L Pereira, David H Adams, Anna Mae Diehl

Viral factors induce Hedgehog pathway activation in humans with viral hepatitis, cirrhosis, and hepatocellular carcinoma

病毒因子可诱导病毒性肝炎、肝硬化和肝细胞癌患者体内 Hedgehog 信号通路激活。

Pereira, Thiago de Almeida; Witek, Rafal P; Syn, Wing-Kin; Choi, Steve S; Bradrick, Shelton; Karaca, Gamze F; Agboola, Kolade M; Jung, Youngmi; Omenetti, Alessia; Moylan, Cynthia A; Yang, Liu; Fernandez-Zapico, Martin E; Jhaveri, Ravi; Shah, Vijay H; Pereira, Fausto E; Diehl, Anna M

Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway.

瘦素通过激活 Hedgehog 信号通路促进肝星状细胞的肌成纤维细胞表型

Choi Steve S, Syn Wing-Kin, Karaca Gamze F, Omenetti Alessia, Moylan Cynthia A, Witek Rafal P, Agboola Kolade M, Jung Youngmi, Michelotti Gregory A, Diehl Anna Mae

Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease

非酒精性脂肪性肝病中 Hedgehog 介导的上皮-间质转化和纤维化修复

Wing-Kin Syn, Youngmi Jung, Alessia Omenetti, Manal Abdelmalek, Cynthia D Guy, Liu Yang, Jiangbo Wang, Rafal P Witek, Caitlin M Fearing, Thiago A Pereira, Vanessa Teaberry, Steve S Choi, J Conde-Vancells, Gamze F Karaca, Anna Mae Diehl