Gan Yu相关文献与解析，生知库 | 链接生命科学的每一步

From target specificity to metabolic efficiency: Design and optimization of etomidate analogues for potential improvement in postoperative outcomes

从靶点特异性到代谢效率：依托咪酯类似物的设计与优化，以期改善术后疗效

doi:10.1016/j.apsb.2026.01.008

Zhao, Yi; Ai, Wei; Zhao, Jieyu; Yang, Xi; Liu, Wencheng; Ma, Yaru; Mou, Jianrui; Hai, Ao; Ji, Ran; Gan, Yu; Miao, Zhuang; Hu, Shilong; Huang, Zhenbo; Liu, Jin; Liu, Xianggen; Yang, Jun; Ke, Bowen

代谢

发表日期：2026

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Dual Targeting of Mutant p53 and SNRPD2 via Engineered Exosomes Modulates Alternative Splicing to Suppress Ovarian Cancer

通过工程化外泌体双重靶向突变型p53和SNRPD2，调节选择性剪接以抑制卵巢癌

期刊:Advanced Science

影响因子:14.1

doi:10.1002/advs.202513369

Zhao, Wei; Hao, Qian; Gan, Yu; Tong, Jing; Chen, Xiaodan; Tan, Shuran; Ruan, Ruiwen; Huang, Yingdan; Cao, Mingming; Deng, Jun; Han, Tao; Shi, Getao; Gao, Bo; Zhang, Yu; Zhou, Xiang

p53 and fatty acids collaborate to trigger ferroptosis via the FBXO2-FABP5 axis in colorectal cancer.

p53 和脂肪酸通过 FBXO2-FABP5 轴协同触发结直肠癌中的铁死亡。

期刊:Redox Biology

影响因子:11.9

doi:10.1016/j.redox.2026.104043

Tong Jing, Han Tao, Deng Jun, Gan Yu, Ruan Ruiwen, Zhao Wei, Xiong Chen, Liao Quan, Chen Shiqi, Bu Huitong, Xiong Jianping, Zhou Xiang, Hao Qian

SMAD7 drives natural killer cell antitumor activity through canonical TGF-β blockade and non-canonical transcriptional activation of STAT5A

SMAD7通过经典的TGF-β阻断和非经典的STAT5A转录激活来驱动自然杀伤细胞的抗肿瘤活性。

期刊:Journal for ImmunoTherapy of Cancer

影响因子:10.6

doi:10.1136/jitc-2025-014473

Li, Jin; Liu, Tingting; Xiao, Wengan; Zhao, Dan; Li, Qian; Liu, Shunan; Li, Xin; Tong, Yi; Li, Huimin; Jiang, Hua; Wu, Shuangjie; Li, Zonghai; Tu, Hong; Gan, Yu

Heterometallic ion-regulated full-color gold nanoclusters for multicolor bioimaging and circularly polarized luminescence

用于多色生物成像和圆偏振发光的异金属离子调控全彩金纳米团簇

期刊:Chemical Science

影响因子:7.4

doi:10.1039/d5sc08291a

Yin, Yaguang; Zhao, Gan; Yu, Fanfan; Liu, Honglin

信号转导

发表日期：2026

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Severe DRESS syndrome with hemophagocytic lymphohistiocytosis and cryptococcal meningitis: a case report and diagnostic challenge

伴有噬血细胞性淋巴组织细胞增生症和隐球菌性脑膜炎的严重药物反应伴嗜酸性粒细胞增多和全身症状（DRESS）综合征：病例报告及诊断挑战

期刊:Frontiers in Immunology

影响因子:5.9

doi:10.3389/fimmu.2026.1703040

Yan, Shi; Gan, Yu-Ting; Li, Jia-Jia; Sheng, Yu; Shi, Bing-Jun

Therapeutic Monitoring of Polymyxin B in Critically Ill Patients with Carbapenem-Resistant Organisms: Evaluation Based on Steady-State Trough and Peak Concentrations

对感染耐碳青霉烯类抗生素的危重患者进行多粘菌素B治疗监测：基于稳态谷浓度和峰浓度的评估

期刊:Drug Design Development and Therapy

影响因子:5.1

doi:10.2147/DDDT.S568529

Yang, Jun; Zhao, Yunpei; Xie, Linli; Gan, Yu; Yu, Mingjie; Yang, Ge; Chen, Yongchuan

炎症/感染

发表日期：2026

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Regulatory immune cells in lung inflammation and fibrosis by carbon nanotubes

碳纳米管对肺部炎症和纤维化中调节性免疫细胞的影响

期刊:Nanomedicine

影响因子:3.9

doi:10.1080/17435889.2026.2644389

Zhang, Xiang; Gan, Yu; Shi, Zhen; Xia, Tianhe; Shen, Yalu; Liu, Zikai; Shen, Tong

EZH2 Inhibition Restores Tumor Suppressor SFRP1 Activity by Reprogramming Extrachromosomal Circular DNA Dynamics in Ovarian Cancer

EZH2抑制通过重编程卵巢癌中染色体外环状DNA的动态变化来恢复肿瘤抑制因子SFRP1的活性

期刊:Biology-Basel

影响因子:3.5

doi:10.3390/biology15040340

Han, Tao; Yan, Qingya; Zhang, Yaqi; Gan, Yu; Li, Kaifan; Guan, Liping; Jing, Changqin; Yang, Ciqing; Li, Pengfei; Gao, Bo; Zhou, Xiang; Hao, Qian

Tackling cuproptosis: from metabolic rewiring to therapeutic exploitation in cancer

攻克铜细胞凋亡：从代谢重编程到癌症治疗的利用

From target specificity to metabolic efficiency: Design and optimization of etomidate analogues for potential improvement in postoperative outcomes

从靶点特异性到代谢效率：依托咪酯类似物的设计与优化，以期改善术后疗效

Dual Targeting of Mutant p53 and SNRPD2 via Engineered Exosomes Modulates Alternative Splicing to Suppress Ovarian Cancer

通过工程化外泌体双重靶向突变型p53和SNRPD2，调节选择性剪接以抑制卵巢癌

p53 and fatty acids collaborate to trigger ferroptosis via the FBXO2-FABP5 axis in colorectal cancer.

p53 和脂肪酸通过 FBXO2-FABP5 轴协同触发结直肠癌中的铁死亡。

SMAD7 drives natural killer cell antitumor activity through canonical TGF-β blockade and non-canonical transcriptional activation of STAT5A

SMAD7通过经典的TGF-β阻断和非经典的STAT5A转录激活来驱动自然杀伤细胞的抗肿瘤活性。

Heterometallic ion-regulated full-color gold nanoclusters for multicolor bioimaging and circularly polarized luminescence

用于多色生物成像和圆偏振发光的异金属离子调控全彩金纳米团簇

Severe DRESS syndrome with hemophagocytic lymphohistiocytosis and cryptococcal meningitis: a case report and diagnostic challenge

伴有噬血细胞性淋巴组织细胞增生症和隐球菌性脑膜炎的严重药物反应伴嗜酸性粒细胞增多和全身症状（DRESS）综合征：病例报告及诊断挑战

Therapeutic Monitoring of Polymyxin B in Critically Ill Patients with Carbapenem-Resistant Organisms: Evaluation Based on Steady-State Trough and Peak Concentrations

对感染耐碳青霉烯类抗生素的危重患者进行多粘菌素B治疗监测：基于稳态谷浓度和峰浓度的评估

Regulatory immune cells in lung inflammation and fibrosis by carbon nanotubes

碳纳米管对肺部炎症和纤维化中调节性免疫细胞的影响

EZH2 Inhibition Restores Tumor Suppressor SFRP1 Activity by Reprogramming Extrachromosomal Circular DNA Dynamics in Ovarian Cancer

EZH2抑制通过重编程卵巢癌中染色体外环状DNA的动态变化来恢复肿瘤抑制因子SFRP1的活性