日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Determination of the pyrrolo[2,3-d] pyrimidine antifolate AGF94 from a preclinical murine study using a simple UHPLC-MS/MS assay

利用简便的超高效液相色谱-串联质谱法（UHPLC-MS/MS）测定临床前小鼠研究中的吡咯并[2,3-d]嘧啶类抗叶酸AGF94。

期刊:Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences
影响因子:2.8
doi:10.1016/j.jchromb.2025.124833
Metz, Tryston T; Ashe, Rachel C; Duncan, Alexis C; Wilner, Ethan C; Schmidt, Keith T; Gudmundsson, Kristbjorn O; Hou, Zhanjun; Gangjee, Aleem; Matherly, Larry H; Kozlov, Serguei V; Figg, William D
多发性硬化症
发表日期：2025
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Mitochondrial and Cytosolic One-Carbon Metabolism Is a Targetable Metabolic Vulnerability in Cisplatin-Resistant Ovarian Cancer

线粒体和细胞浆一碳代谢是顺铂耐药卵巢癌中可靶向的代谢弱点

期刊:Molecular Cancer Therapeutics
影响因子:5.3
doi:10.1158/1535-7163.MCT-23-0550
Adrianne Wallace-Povirk, Carrie O'Connor, Aamod S Dekhne, Xun Bao, Md Junayed Nayeen, Mathew Schneider, Jade M Katinas, Jennifer Wong-Roushar, Seongho Kim, Lisa Polin, Jing Li, Jessica B Back, Charles E Dann 3rd, Aleem Gangjee, Zhanjun Hou, Larry H Matherly
代谢
卵巢癌
肿瘤细胞
发表日期：2024
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Role of Mitochondrial and Cytosolic Folylpolyglutamate Synthetase in One-Carbon Metabolism and Antitumor Efficacy of Mitochondrial-Targeted Antifolates

线粒体和胞质叶酸多聚谷氨酸合成酶在单碳代谢中的作用及线粒体靶向抗叶酸药物的抗肿瘤疗效

期刊:Molecular Pharmacology
影响因子:3
doi:10.1124/molpharm.124.000912
O'Connor, Carrie; Schneider, Mathew; Katinas, Jade M; Nayeen, Md Junayed; Shah, Khushbu; Magdum, Tejashree; Sharma, Abhishekh; Kim, Seongho; Bao, Xun; Li, Jing; Dann, Charles E; Gangjee, Aleem; Matherly, Larry H; Hou, Zhanjun
代谢
线粒体
肿瘤
肿瘤免疫
发表日期：2024
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Structural Characterization of 5-Substituted Pyrrolo[3,2-d]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2

5-取代吡咯并[3,2-d]嘧啶类抗叶酸抑制剂与人丝氨酸羟甲基转移酶2复合物的结构表征

期刊:Biochemistry
影响因子:3
doi:10.1021/acs.biochem.3c00613
Katinas, Jade M; Nayeen, Md Junayed; Schneider, Mathew; Shah, Khushbu; Fifer, Alexandra N; Klapper, Lily M; Sharma, Abhishekh; Thalluri, Kishore; Van Nieuwenhze, Michael S; Hou, Zhanjun; Gangjee, Aleem; Matherly, Larry H; Dann, Charles E 3rd
Human
发表日期：2024
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Simple monocyclic pyrimidine analogs as microtubule targeting agents binding to the colchicine site

简单的单环嘧啶类似物作为微管靶向剂，可与秋水仙碱位点结合

期刊:Bioorganic & Medicinal Chemistry
影响因子:3
doi:10.1016/j.bmc.2023.117217
Choudhary, Shruti; Kaku, Krishna; Robles, Andrew J; Hamel, Ernest; Mooberry, Susan L; Gangjee, Aleem
发表日期：2023
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Design, Synthesis, and Biological Evaluation of 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines as Microtubule Targeting Agents

5,6,7,8-四氢苯并[4,5]噻吩并[2,3-d]嘧啶类化合物作为微管靶向剂的设计、合成及生物学评价

期刊:Molecules
影响因子:4.6
doi:10.3390/molecules27010321
Islam, Farhana; Doshi, Arpit; Robles, Andrew J; Quadery, Tasdique M; Zhang, Xin; Zhou, Xilin; Hamel, Ernest; Mooberry, Susan L; Gangjee, Aleem
发表日期：2022
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Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment

在同源小鼠高级别浆液性卵巢癌模型中，吡咯并[2,3-d]嘧啶类抗叶酸靶向治疗及其对肿瘤微环境的影响

期刊:Scientific Reports
影响因子:3.8
doi:10.1038/s41598-022-14788-5
Adrianne Wallace-Povirk ，Lisa Rubinsak ，Agnes Malysa ，Sijana H Dzinic ，Manasa Ravindra ，Mathew Schneider ，James Glassbrook ，Carrie O'Connor ，Zhanjun Hou ，Seongho Kim ，Jessica Back ，Lisa Polin ，Robert T Morris ，Aleem Gangjee ，Heather Gibson ，Larry H Matherly
肿瘤微环境
卵巢癌
肿瘤免疫
肿瘤
发表日期：2022
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Biology and therapeutic applications of the proton-coupled folate transporter

质子偶联叶酸转运体的生物学和治疗应用

期刊:
影响因子:
doi:10.1080/17425255.2022.2136071
Matherly, Larry H; Schneider, Mathew; Gangjee, Aleem; Hou, Zhanjun
发表日期：2022
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Folate Transport and One-Carbon Metabolism in Targeted Therapies of Epithelial Ovarian Cancer

叶酸转运和一碳代谢在卵巢上皮癌靶向治疗中的作用

期刊:Cancers
影响因子:4.4
doi:10.3390/cancers14010191
Wallace-Povirk, Adrianne; Hou, Zhanjun; Nayeen, Md Junayed; Gangjee, Aleem; Matherly, Larry H
肿瘤
肿瘤免疫
代谢
发表日期：2021
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Folate transporter dynamics and therapy with classic and tumor-targeted antifolates

叶酸转运蛋白动力学以及经典和肿瘤靶向抗叶酸药物治疗

期刊:Scientific Reports
影响因子:3.8
doi:10.1038/s41598-021-85818-x
Carrie O'Connor, Adrianne Wallace-Povirk, Changwen Ning, Josephine Frühauf, Nian Tong, Aleem Gangjee, Larry H Matherly, Zhanjun Hou
肿瘤
AT1A1
发表日期：2021
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